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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-100022457-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=100022457&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 100022457,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "ENST00000533028.8",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.959G>A",
          "hgvs_p": "p.Gly320Glu",
          "transcript": "NM_012243.3",
          "protein_id": "NP_036375.1",
          "transcript_support_level": null,
          "aa_start": 320,
          "aa_end": null,
          "aa_length": 325,
          "cds_start": 959,
          "cds_end": null,
          "cds_length": 978,
          "cdna_start": 1144,
          "cdna_end": null,
          "cdna_length": 14321,
          "mane_select": "ENST00000533028.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.959G>A",
          "hgvs_p": "p.Gly320Glu",
          "transcript": "ENST00000533028.8",
          "protein_id": "ENSP00000433849.1",
          "transcript_support_level": 1,
          "aa_start": 320,
          "aa_end": null,
          "aa_length": 325,
          "cds_start": 959,
          "cds_end": null,
          "cds_length": 978,
          "cdna_start": 1144,
          "cdna_end": null,
          "cdna_length": 14321,
          "mane_select": "NM_012243.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.*43G>A",
          "hgvs_p": null,
          "transcript": "ENST00000638336.1",
          "protein_id": "ENSP00000491145.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 220,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 663,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2438,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000283761",
          "gene_hgnc_id": null,
          "hgvs_c": "c.753+7037G>A",
          "hgvs_p": null,
          "transcript": "ENST00000639037.1",
          "protein_id": "ENSP00000492745.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 713,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2142,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2590,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.1085G>A",
          "hgvs_p": "p.Gly362Glu",
          "transcript": "NM_001271685.2",
          "protein_id": "NP_001258614.1",
          "transcript_support_level": null,
          "aa_start": 362,
          "aa_end": null,
          "aa_length": 367,
          "cds_start": 1085,
          "cds_end": null,
          "cds_length": 1104,
          "cdna_start": 1105,
          "cdna_end": null,
          "cdna_length": 14282,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.1085G>A",
          "hgvs_p": "p.Gly362Glu",
          "transcript": "ENST00000370153.6",
          "protein_id": "ENSP00000359172.1",
          "transcript_support_level": 5,
          "aa_start": 362,
          "aa_end": null,
          "aa_length": 367,
          "cds_start": 1085,
          "cds_end": null,
          "cds_length": 1104,
          "cdna_start": 1186,
          "cdna_end": null,
          "cdna_length": 5708,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.959G>A",
          "hgvs_p": "p.Gly320Glu",
          "transcript": "NM_001438725.1",
          "protein_id": "NP_001425654.1",
          "transcript_support_level": null,
          "aa_start": 320,
          "aa_end": null,
          "aa_length": 325,
          "cds_start": 959,
          "cds_end": null,
          "cds_length": 978,
          "cdna_start": 1243,
          "cdna_end": null,
          "cdna_length": 14420,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.959G>A",
          "hgvs_p": "p.Gly320Glu",
          "transcript": "ENST00000427993.7",
          "protein_id": "ENSP00000414947.2",
          "transcript_support_level": 5,
          "aa_start": 320,
          "aa_end": null,
          "aa_length": 325,
          "cds_start": 959,
          "cds_end": null,
          "cds_length": 978,
          "cdna_start": 1260,
          "cdna_end": null,
          "cdna_length": 2062,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.959G>A",
          "hgvs_p": "p.Gly320Glu",
          "transcript": "ENST00000465289.6",
          "protein_id": "ENSP00000418527.2",
          "transcript_support_level": 5,
          "aa_start": 320,
          "aa_end": null,
          "aa_length": 325,
          "cds_start": 959,
          "cds_end": null,
          "cds_length": 978,
          "cdna_start": 1265,
          "cdna_end": null,
          "cdna_length": 5696,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.836G>A",
          "hgvs_p": "p.Gly279Glu",
          "transcript": "NM_001437717.1",
          "protein_id": "NP_001424646.1",
          "transcript_support_level": null,
          "aa_start": 279,
          "aa_end": null,
          "aa_length": 284,
          "cds_start": 836,
          "cds_end": null,
          "cds_length": 855,
          "cdna_start": 1021,
          "cdna_end": null,
          "cdna_length": 14198,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.836G>A",
          "hgvs_p": "p.Gly279Glu",
          "transcript": "ENST00000640732.1",
          "protein_id": "ENSP00000492771.1",
          "transcript_support_level": 5,
          "aa_start": 279,
          "aa_end": null,
          "aa_length": 284,
          "cds_start": 836,
          "cds_end": null,
          "cds_length": 855,
          "cdna_start": 987,
          "cdna_end": null,
          "cdna_length": 1777,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.962G>A",
          "hgvs_p": "p.Gly321Glu",
          "transcript": "XM_011541135.4",
          "protein_id": "XP_011539437.1",
          "transcript_support_level": null,
          "aa_start": 321,
          "aa_end": null,
          "aa_length": 326,
          "cds_start": 962,
          "cds_end": null,
          "cds_length": 981,
          "cdna_start": 982,
          "cdna_end": null,
          "cdna_length": 14159,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "n.*765G>A",
          "hgvs_p": null,
          "transcript": "ENST00000370155.9",
          "protein_id": "ENSP00000359174.5",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2454,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "n.*471G>A",
          "hgvs_p": null,
          "transcript": "ENST00000639148.1",
          "protein_id": "ENSP00000491383.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1644,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "n.*561G>A",
          "hgvs_p": null,
          "transcript": "ENST00000640178.1",
          "protein_id": "ENSP00000491771.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2446,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "n.*308G>A",
          "hgvs_p": null,
          "transcript": "ENST00000640360.1",
          "protein_id": "ENSP00000491598.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4437,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.*15G>A",
          "hgvs_p": null,
          "transcript": "NM_001438728.1",
          "protein_id": "NP_001425657.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 269,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 810,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 14187,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.*15G>A",
          "hgvs_p": null,
          "transcript": "ENST00000640715.1",
          "protein_id": "ENSP00000492801.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 269,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 810,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1989,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.*15G>A",
          "hgvs_p": null,
          "transcript": "NM_001437713.1",
          "protein_id": "NP_001424642.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 228,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 687,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 14064,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.*15G>A",
          "hgvs_p": null,
          "transcript": "ENST00000639221.1",
          "protein_id": "ENSP00000492169.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 228,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 687,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1032,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC35A3",
          "gene_hgnc_id": 11023,
          "hgvs_c": "c.*43G>A",
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      "acmg_by_gene": [
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          "verdict": "Uncertain_significance",
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          "verdict": "Uncertain_significance",
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          "verdict": "Uncertain_significance",
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      "clinvar_disease": "Autism spectrum disorder - epilepsy - arthrogryposis syndrome",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "Autism spectrum disorder - epilepsy - arthrogryposis syndrome",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
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  "message": null
}