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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-109750234-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=109750234&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 109750234,
"ref": "G",
"alt": "T",
"effect": "3_prime_UTR_variant",
"transcript": "NM_139053.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "NM_133181.4",
"protein_id": "NP_573444.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 593,
"cds_start": null,
"cds_end": null,
"cds_length": 1782,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000361965.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_133181.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000361965.9",
"protein_id": "ENSP00000355255.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 593,
"cds_start": null,
"cds_end": null,
"cds_length": 1782,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_133181.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361965.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000369805.7",
"protein_id": "ENSP00000358820.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 594,
"cds_start": null,
"cds_end": null,
"cds_length": 1785,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000369805.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000361852.8",
"protein_id": "ENSP00000354551.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 563,
"cds_start": null,
"cds_end": null,
"cds_length": 1692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361852.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888981.1",
"protein_id": "ENSP00000559040.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 675,
"cds_start": null,
"cds_end": null,
"cds_length": 2028,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888981.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888977.1",
"protein_id": "ENSP00000559036.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 674,
"cds_start": null,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888977.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888985.1",
"protein_id": "ENSP00000559044.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 673,
"cds_start": null,
"cds_end": null,
"cds_length": 2022,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888985.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888976.1",
"protein_id": "ENSP00000559035.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 645,
"cds_start": null,
"cds_end": null,
"cds_length": 1938,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888976.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888982.1",
"protein_id": "ENSP00000559041.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 644,
"cds_start": null,
"cds_end": null,
"cds_length": 1935,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888982.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888983.1",
"protein_id": "ENSP00000559042.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 602,
"cds_start": null,
"cds_end": null,
"cds_length": 1809,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888983.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888978.1",
"protein_id": "ENSP00000559037.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 601,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000888978.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
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"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "NM_139053.3",
"protein_id": "NP_620641.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_139053.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
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"gene_symbol": "EPS8L3",
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"hgvs_c": "c.*157C>A",
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"transcript": "ENST00000888980.1",
"protein_id": "ENSP00000559039.1",
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000888980.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
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"intron_rank": null,
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"gene_symbol": "EPS8L3",
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"hgvs_c": "c.*157C>A",
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"feature": "ENST00000888974.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
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"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888975.1",
"protein_id": "ENSP00000559034.1",
"transcript_support_level": null,
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"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888975.1"
},
{
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"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
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"intron_rank": null,
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"gene_symbol": "EPS8L3",
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"hgvs_c": "c.*157C>A",
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"transcript": "ENST00000888973.1",
"protein_id": "ENSP00000559032.1",
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"biotype": "protein_coding",
"feature": "ENST00000888973.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
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"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "NM_024526.4",
"protein_id": "NP_078802.2",
"transcript_support_level": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_024526.4"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888979.1",
"protein_id": "ENSP00000559038.1",
"transcript_support_level": null,
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"cds_start": null,
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},
{
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"strand": false,
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],
"exon_rank": 19,
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"exon_count": 19,
"intron_rank": null,
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"gene_symbol": "EPS8L3",
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"hgvs_c": "c.*157C>A",
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "EPS8L3",
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"hgvs_c": "c.*157C>A",
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"transcript": "ENST00000952210.1",
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},
{
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"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
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"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "NM_001319952.2",
"protein_id": "NP_001306881.1",
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"aa_start": null,
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"aa_length": 530,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001319952.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EPS8L3",
"gene_hgnc_id": 21297,
"hgvs_c": "c.*157C>A",
"hgvs_p": null,
"transcript": "ENST00000888984.1",
"protein_id": "ENSP00000559043.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 516,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888984.1"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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