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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-150829796-AT-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=150829796&ref=AT&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 150829796,
"ref": "AT",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000358595.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.1032+107delA",
"hgvs_p": null,
"transcript": "NM_001668.4",
"protein_id": "NP_001659.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 789,
"cds_start": -4,
"cds_end": null,
"cds_length": 2370,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4710,
"mane_select": "ENST00000358595.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.1032+107delA",
"hgvs_p": null,
"transcript": "ENST00000358595.10",
"protein_id": "ENSP00000351407.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 789,
"cds_start": -4,
"cds_end": null,
"cds_length": 2370,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4710,
"mane_select": "NM_001668.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.1032+107delA",
"hgvs_p": null,
"transcript": "ENST00000354396.6",
"protein_id": "ENSP00000346372.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 787,
"cds_start": -4,
"cds_end": null,
"cds_length": 2364,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3538,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.990+107delA",
"hgvs_p": null,
"transcript": "ENST00000515192.5",
"protein_id": "ENSP00000423851.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 775,
"cds_start": -4,
"cds_end": null,
"cds_length": 2328,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2892,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "n.1032+107delA",
"hgvs_p": null,
"transcript": "ENST00000471844.6",
"protein_id": "ENSP00000425899.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3703,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.1029+107delA",
"hgvs_p": null,
"transcript": "NM_001350225.2",
"protein_id": "NP_001337154.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 788,
"cds_start": -4,
"cds_end": null,
"cds_length": 2367,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4744,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.1032+107delA",
"hgvs_p": null,
"transcript": "NM_001286036.2",
"protein_id": "NP_001272965.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 787,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4704,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.1026+107delA",
"hgvs_p": null,
"transcript": "NM_001350226.2",
"protein_id": "NP_001337155.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 787,
"cds_start": -4,
"cds_end": null,
"cds_length": 2364,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4741,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.1005+107delA",
"hgvs_p": null,
"transcript": "NM_001350224.2",
"protein_id": "NP_001337153.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 780,
"cds_start": -4,
"cds_end": null,
"cds_length": 2343,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4745,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 12,
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"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.990+107delA",
"hgvs_p": null,
"transcript": "NM_001286035.2",
"protein_id": "NP_001272964.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 10,
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"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.987+107delA",
"hgvs_p": null,
"transcript": "NM_178427.3",
"protein_id": "NP_848514.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "ARNT",
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"transcript": "ENST00000505755.5",
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},
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],
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"gene_symbol": "ARNT",
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],
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"transcript": "ENST00000478972.2",
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},
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],
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},
{
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],
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"gene_symbol": "ARNT",
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"hgvs_c": "c.1029+107delA",
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},
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},
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],
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"gene_symbol": "ARNT",
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"hgvs_c": "c.1017+107delA",
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"transcript": "XM_005245153.2",
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},
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],
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"intron_rank": 11,
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"gene_symbol": "ARNT",
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"hgvs_c": "c.1017+107delA",
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"transcript": "XM_047420711.1",
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],
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"gene_symbol": "ARNT",
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"hgvs_c": "c.990+107delA",
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"transcript": "XM_047420692.1",
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},
{
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"protein_coding": true,
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"consequences": [
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],
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"exon_count": 22,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARNT",
"gene_hgnc_id": 700,
"hgvs_c": "c.984+107delA",
"hgvs_p": null,
"transcript": "XM_047420712.1",
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},
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"strand": false,
"consequences": [
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