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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-150997739-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=150997739&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 150997739,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001376664.1",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "NM_001376665.1",
"protein_id": "NP_001363594.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000683666.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376665.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000683666.2",
"protein_id": "ENSP00000507359.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001376665.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683666.2"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000361936.9",
"protein_id": "ENSP00000354814.5",
"transcript_support_level": 1,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361936.9"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1226G>A",
"hgvs_p": "p.Arg409Gln",
"transcript": "ENST00000943009.1",
"protein_id": "ENSP00000613068.1",
"transcript_support_level": null,
"aa_start": 409,
"aa_end": null,
"aa_length": 473,
"cds_start": 1226,
"cds_end": null,
"cds_length": 1422,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943009.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1217G>A",
"hgvs_p": "p.Arg406Gln",
"transcript": "NM_001376664.1",
"protein_id": "NP_001363593.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 470,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1413,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376664.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "NM_001163258.3",
"protein_id": "NP_001156730.3",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001163258.3"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "NM_001319998.2",
"protein_id": "NP_001306927.2",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001319998.2"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "NM_018379.5",
"protein_id": "NP_060849.3",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018379.5"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000361738.12",
"protein_id": "ENSP00000354669.7",
"transcript_support_level": 2,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361738.12"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000888222.1",
"protein_id": "ENSP00000558281.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888222.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000888224.1",
"protein_id": "ENSP00000558283.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888224.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000931104.1",
"protein_id": "ENSP00000601163.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931104.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000931106.1",
"protein_id": "ENSP00000601165.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931106.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000943004.1",
"protein_id": "ENSP00000613063.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943004.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1214G>A",
"hgvs_p": "p.Arg405Gln",
"transcript": "ENST00000943008.1",
"protein_id": "ENSP00000613067.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 469,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943008.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1205G>A",
"hgvs_p": "p.Arg402Gln",
"transcript": "ENST00000888227.1",
"protein_id": "ENSP00000558286.1",
"transcript_support_level": null,
"aa_start": 402,
"aa_end": null,
"aa_length": 466,
"cds_start": 1205,
"cds_end": null,
"cds_length": 1401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888227.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1205G>A",
"hgvs_p": "p.Arg402Gln",
"transcript": "ENST00000888230.1",
"protein_id": "ENSP00000558289.1",
"transcript_support_level": null,
"aa_start": 402,
"aa_end": null,
"aa_length": 466,
"cds_start": 1205,
"cds_end": null,
"cds_length": 1401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888230.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1190G>A",
"hgvs_p": "p.Arg397Gln",
"transcript": "NM_001376666.1",
"protein_id": "NP_001363595.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 461,
"cds_start": 1190,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376666.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1190G>A",
"hgvs_p": "p.Arg397Gln",
"transcript": "ENST00000943000.1",
"protein_id": "ENSP00000613059.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 461,
"cds_start": 1190,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943000.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1190G>A",
"hgvs_p": "p.Arg397Gln",
"transcript": "ENST00000943010.1",
"protein_id": "ENSP00000613069.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 461,
"cds_start": 1190,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943010.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1187G>A",
"hgvs_p": "p.Arg396Gln",
"transcript": "NM_001376667.1",
"protein_id": "NP_001363596.1",
"transcript_support_level": null,
"aa_start": 396,
"aa_end": null,
"aa_length": 460,
"cds_start": 1187,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376667.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY1",
"gene_hgnc_id": 25648,
"hgvs_c": "c.1187G>A",
"hgvs_p": "p.Arg396Gln",
"transcript": "NM_001376668.1",
"protein_id": "NP_001363597.1",
"transcript_support_level": null,
"aa_start": 396,
"aa_end": null,
"aa_length": 460,
"cds_start": 1187,
"cds_end": null,
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}
],
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}