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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-151031124-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=151031124&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 151031124,
      "ref": "T",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "NM_021222.3",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.933+2180T>C",
          "hgvs_p": null,
          "transcript": "NM_021222.3",
          "protein_id": "NP_067045.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 453,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1362,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000271620.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_021222.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.933+2180T>C",
          "hgvs_p": null,
          "transcript": "ENST00000271620.8",
          "protein_id": "ENSP00000271620.3",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 453,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1362,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_021222.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000271620.8"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.387+2180T>C",
          "hgvs_p": null,
          "transcript": "ENST00000368936.5",
          "protein_id": "ENSP00000357932.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 271,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 816,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000368936.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.229-2682T>C",
          "hgvs_p": null,
          "transcript": "ENST00000368937.5",
          "protein_id": "ENSP00000357933.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 218,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 657,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000368937.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.79-2682T>C",
          "hgvs_p": null,
          "transcript": "ENST00000368935.1",
          "protein_id": "ENSP00000357931.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 168,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 507,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000368935.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.934-248T>C",
          "hgvs_p": null,
          "transcript": "ENST00000895151.1",
          "protein_id": "ENSP00000565210.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000895151.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.844-248T>C",
          "hgvs_p": null,
          "transcript": "ENST00000650332.1",
          "protein_id": "ENSP00000497847.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 454,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1365,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000650332.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.841-248T>C",
          "hgvs_p": null,
          "transcript": "ENST00000895153.1",
          "protein_id": "ENSP00000565212.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 453,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1362,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000895153.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.775-2682T>C",
          "hgvs_p": null,
          "transcript": "NM_001303242.2",
          "protein_id": "NP_001290171.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 400,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1203,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001303242.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.774+2180T>C",
          "hgvs_p": null,
          "transcript": "ENST00000895152.1",
          "protein_id": "ENSP00000565211.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 400,
          "cds_start": null,
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          "cds_length": 1203,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          "exon_rank": null,
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          "exon_count": 7,
          "intron_rank": 6,
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          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.387+2180T>C",
          "hgvs_p": null,
          "transcript": "NM_001303229.2",
          "protein_id": "NP_001290158.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 271,
          "cds_start": null,
          "cds_end": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": true,
          "consequences": [
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          "intron_rank": 5,
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          "gene_symbol": "PRUNE1",
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          "hgvs_c": "c.330+2180T>C",
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          "transcript": "NM_001303243.2",
          "protein_id": "NP_001290172.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "cds_start": null,
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          "cdna_start": null,
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        {
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          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
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          "transcript": "ENST00000368934.1",
          "protein_id": "ENSP00000357930.1",
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        {
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          "exon_count": 3,
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          "gene_symbol": "PRUNE1",
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          "hgvs_c": "c.133-2682T>C",
          "hgvs_p": null,
          "transcript": "ENST00000916910.1",
          "protein_id": "ENSP00000586969.1",
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        {
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          "intron_rank": 5,
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          "gene_symbol": "PRUNE1",
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          "transcript": "ENST00000450884.5",
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          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.843+2180T>C",
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          "transcript": "XM_005245393.6",
          "protein_id": "XP_005245450.1",
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        {
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          ],
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          "intron_rank_end": null,
          "gene_symbol": "PRUNE1",
          "gene_hgnc_id": 13420,
          "hgvs_c": "c.387+2180T>C",
          "hgvs_p": null,
          "transcript": "XM_047426607.1",
          "protein_id": "XP_047282563.1",
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      ],
      "gene_symbol": "PRUNE1",
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      "dbsnp": "rs4970989",
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      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.8100000023841858,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.81,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.126,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
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      "apogee2_score": null,
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      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
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            "BP4_Strong"
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          "verdict": "Likely_benign",
          "transcript": "NM_021222.3",
          "gene_symbol": "PRUNE1",
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          "inheritance_mode": "AR",
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      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}