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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-151406151-C-CA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=151406151&ref=C&alt=CA&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 151406151,
      "ref": "C",
      "alt": "CA",
      "effect": "frameshift_variant",
      "transcript": "ENST00000271715.7",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2883dupT",
          "hgvs_p": "p.Gly962fs",
          "transcript": "NM_015100.4",
          "protein_id": "NP_055915.2",
          "transcript_support_level": null,
          "aa_start": 961,
          "aa_end": null,
          "aa_length": 1410,
          "cds_start": 2883,
          "cds_end": null,
          "cds_length": 4233,
          "cdna_start": 3227,
          "cdna_end": null,
          "cdna_length": 6655,
          "mane_select": "ENST00000271715.7",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2883dupT",
          "hgvs_p": "p.Gly962fs",
          "transcript": "ENST00000271715.7",
          "protein_id": "ENSP00000271715.2",
          "transcript_support_level": 1,
          "aa_start": 961,
          "aa_end": null,
          "aa_length": 1410,
          "cds_start": 2883,
          "cds_end": null,
          "cds_length": 4233,
          "cdna_start": 3227,
          "cdna_end": null,
          "cdna_length": 6655,
          "mane_select": "NM_015100.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2724dupT",
          "hgvs_p": "p.Gly909fs",
          "transcript": "ENST00000392723.6",
          "protein_id": "ENSP00000376484.1",
          "transcript_support_level": 1,
          "aa_start": 908,
          "aa_end": null,
          "aa_length": 1357,
          "cds_start": 2724,
          "cds_end": null,
          "cds_length": 4074,
          "cdna_start": 2753,
          "cdna_end": null,
          "cdna_length": 6181,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2598dupT",
          "hgvs_p": "p.Gly867fs",
          "transcript": "ENST00000368863.6",
          "protein_id": "ENSP00000357856.2",
          "transcript_support_level": 1,
          "aa_start": 866,
          "aa_end": null,
          "aa_length": 1315,
          "cds_start": 2598,
          "cds_end": null,
          "cds_length": 3948,
          "cdna_start": 2627,
          "cdna_end": null,
          "cdna_length": 6054,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2931dupT",
          "hgvs_p": "p.Gly978fs",
          "transcript": "ENST00000710270.1",
          "protein_id": "ENSP00000518163.1",
          "transcript_support_level": null,
          "aa_start": 977,
          "aa_end": null,
          "aa_length": 1426,
          "cds_start": 2931,
          "cds_end": null,
          "cds_length": 4281,
          "cdna_start": 3227,
          "cdna_end": null,
          "cdna_length": 6655,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2904dupT",
          "hgvs_p": "p.Gly969fs",
          "transcript": "NM_001410860.1",
          "protein_id": "NP_001397789.1",
          "transcript_support_level": null,
          "aa_start": 968,
          "aa_end": null,
          "aa_length": 1417,
          "cds_start": 2904,
          "cds_end": null,
          "cds_length": 4254,
          "cdna_start": 3024,
          "cdna_end": null,
          "cdna_length": 6452,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2904dupT",
          "hgvs_p": "p.Gly969fs",
          "transcript": "ENST00000703168.1",
          "protein_id": "ENSP00000515214.1",
          "transcript_support_level": null,
          "aa_start": 968,
          "aa_end": null,
          "aa_length": 1417,
          "cds_start": 2904,
          "cds_end": null,
          "cds_length": 4254,
          "cdna_start": 3000,
          "cdna_end": null,
          "cdna_length": 4350,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2883dupT",
          "hgvs_p": "p.Gly962fs",
          "transcript": "ENST00000439756.2",
          "protein_id": "ENSP00000390156.2",
          "transcript_support_level": 3,
          "aa_start": 961,
          "aa_end": null,
          "aa_length": 1410,
          "cds_start": 2883,
          "cds_end": null,
          "cds_length": 4233,
          "cdna_start": 4462,
          "cdna_end": null,
          "cdna_length": 5812,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2856dupT",
          "hgvs_p": "p.Gly953fs",
          "transcript": "NM_001194937.2",
          "protein_id": "NP_001181866.1",
          "transcript_support_level": null,
          "aa_start": 952,
          "aa_end": null,
          "aa_length": 1401,
          "cds_start": 2856,
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          "cds_length": 4206,
          "cdna_start": 3200,
          "cdna_end": null,
          "cdna_length": 6628,
          "mane_select": null,
          "mane_plus": null,
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          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "G?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
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          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2856dupT",
          "hgvs_p": "p.Gly953fs",
          "transcript": "ENST00000409503.5",
          "protein_id": "ENSP00000386836.1",
          "transcript_support_level": 2,
          "aa_start": 952,
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          "cds_start": 2856,
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          "cdna_start": 2885,
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          "mane_select": null,
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        {
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          "canonical": false,
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          "consequences": [
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          ],
          "exon_rank": 18,
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          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2751dupT",
          "hgvs_p": "p.Gly918fs",
          "transcript": "ENST00000491586.5",
          "protein_id": "ENSP00000418408.1",
          "transcript_support_level": 5,
          "aa_start": 917,
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          "aa_length": 1366,
          "cds_start": 2751,
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          "cdna_start": 2780,
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        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          "exon_count": 17,
          "intron_rank": null,
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          "gene_symbol": "POGZ",
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          "hgvs_c": "c.2724dupT",
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          "transcript": "NM_207171.2",
          "protein_id": "NP_997054.1",
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        {
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          "hgvs_c": "c.2697dupT",
          "hgvs_p": "p.Gly900fs",
          "transcript": "NM_001194938.2",
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        {
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          ],
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          "gene_symbol": "POGZ",
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          "hgvs_c": "c.2697dupT",
          "hgvs_p": "p.Gly900fs",
          "transcript": "ENST00000531094.5",
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        {
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        {
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          "gene_symbol": "POGZ",
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          "hgvs_c": "c.2883dupT",
          "hgvs_p": "p.Gly962fs",
          "transcript": "XM_005245000.5",
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          "canonical": false,
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        {
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        {
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        {
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          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.2745dupT",
          "hgvs_p": "p.Gly916fs",
          "transcript": "XM_017000748.2",
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        },
        {
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          "strand": false,
          "consequences": [
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          ],
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          "intron_rank": null,
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        {
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          "hgvs_p": "p.Gly907fs",
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        {
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          "gene_symbol": "POGZ",
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          "hgvs_c": "c.2697dupT",
          "hgvs_p": "p.Gly900fs",
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        },
        {
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          ],
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          "intron_rank": null,
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          "gene_symbol": "POGZ",
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          "hgvs_c": "c.1683dupT",
          "hgvs_p": "p.Gly562fs",
          "transcript": "XM_047450070.1",
          "protein_id": "XP_047306026.1",
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        },
        {
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          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 17,
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          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "n.3031dupT",
          "hgvs_p": null,
          "transcript": "ENST00000358476.7",
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        },
        {
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          "protein_coding": true,
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          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "POGZ",
          "gene_hgnc_id": 18801,
          "hgvs_c": "c.*134dupT",
          "hgvs_p": null,
          "transcript": "ENST00000529669.1",
          "protein_id": "ENSP00000432295.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cds_start": -4,
          "cds_end": null,
          "cds_length": 949,
          "cdna_start": null,
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          "cdna_length": 949,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "POGZ",
      "gene_hgnc_id": 18801,
      "dbsnp": "rs1553212626",
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": -1.046,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 12,
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PVS1,PM2,PP5_Moderate",
      "acmg_by_gene": [
        {
          "score": 12,
          "benign_score": 0,
          "pathogenic_score": 12,
          "criteria": [
            "PVS1",
            "PM2",
            "PP5_Moderate"
          ],
          "verdict": "Pathogenic",
          "transcript": "ENST00000271715.7",
          "gene_symbol": "POGZ",
          "hgnc_id": 18801,
          "effects": [
            "frameshift_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.2883dupT",
          "hgvs_p": "p.Gly962fs"
        }
      ],
      "clinvar_disease": "Inborn genetic diseases",
      "clinvar_classification": "Pathogenic",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "P:1",
      "phenotype_combined": "Inborn genetic diseases",
      "pathogenicity_classification_combined": "Pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}