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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-154971680-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=154971680&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 154971680,
"ref": "A",
"alt": "G",
"effect": "5_prime_UTR_variant",
"transcript": "XM_047427958.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "ENST00000368453.8",
"protein_id": "ENSP00000357438.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 474,
"cds_start": -4,
"cds_end": null,
"cds_length": 1425,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3062,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "ENST00000368450.5",
"protein_id": "ENSP00000357435.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 473,
"cds_start": -4,
"cds_end": null,
"cds_length": 1422,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3059,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-1154T>C",
"hgvs_p": null,
"transcript": "XM_047427958.1",
"protein_id": "XP_047283914.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 583,
"cds_start": -4,
"cds_end": null,
"cds_length": 1752,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6368,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-1154T>C",
"hgvs_p": null,
"transcript": "XM_047427959.1",
"protein_id": "XP_047283915.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 565,
"cds_start": -4,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6314,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "NM_003029.5",
"protein_id": "NP_003020.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 474,
"cds_start": -4,
"cds_end": null,
"cds_length": 1425,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3062,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "NM_001130041.2",
"protein_id": "NP_001123513.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 473,
"cds_start": -4,
"cds_end": null,
"cds_length": 1422,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3059,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-138-1481T>C",
"hgvs_p": null,
"transcript": "NM_001202859.2",
"protein_id": "NP_001189788.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 428,
"cds_start": -4,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3059,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "ENST00000412170.5",
"protein_id": "ENSP00000398441.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 199,
"cds_start": -4,
"cds_end": null,
"cds_length": 600,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 692,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "ENST00000366442.2",
"protein_id": "ENSP00000396162.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 136,
"cds_start": -4,
"cds_end": null,
"cds_length": 413,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 780,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 1,
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"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "XM_005245451.5",
"protein_id": "XP_005245508.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 488,
"cds_start": -4,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
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"cdna_length": 1679,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "XM_047427967.1",
"protein_id": "XP_047283923.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 488,
"cds_start": -4,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
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"gene_symbol": "SHC1",
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"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427968.1",
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},
{
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"strand": false,
"consequences": [
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],
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"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427969.1",
"protein_id": "XP_047283925.1",
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},
{
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],
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"gene_symbol": "SHC1",
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"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427970.1",
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],
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},
{
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"strand": false,
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],
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"intron_rank": 1,
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"gene_symbol": "SHC1",
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"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427972.1",
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},
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"gene_symbol": "SHC1",
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"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427973.1",
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},
{
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],
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"gene_symbol": "SHC1",
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"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427974.1",
"protein_id": "XP_047283930.1",
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},
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "SHC1",
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"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427975.1",
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},
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],
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
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"transcript": "XM_047427983.1",
"protein_id": "XP_047283939.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SHC1",
"gene_hgnc_id": 10840,
"hgvs_c": "c.-3-1481T>C",
"hgvs_p": null,
"transcript": "XM_047427984.1",
"protein_id": "XP_047283940.1",
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}