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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-16033179-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=16033179&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 16033179,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_004070.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1939C>T",
"hgvs_p": "p.Leu647Phe",
"transcript": "NM_004070.4",
"protein_id": "NP_004061.3",
"transcript_support_level": null,
"aa_start": 647,
"aa_end": null,
"aa_length": 687,
"cds_start": 1939,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000331433.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004070.4"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1939C>T",
"hgvs_p": "p.Leu647Phe",
"transcript": "ENST00000331433.5",
"protein_id": "ENSP00000332771.4",
"transcript_support_level": 1,
"aa_start": 647,
"aa_end": null,
"aa_length": 687,
"cds_start": 1939,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004070.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000331433.5"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1936C>T",
"hgvs_p": "p.Leu646Phe",
"transcript": "ENST00000375692.5",
"protein_id": "ENSP00000364844.1",
"transcript_support_level": 1,
"aa_start": 646,
"aa_end": null,
"aa_length": 686,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375692.5"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1978C>T",
"hgvs_p": "p.Leu660Phe",
"transcript": "ENST00000861487.1",
"protein_id": "ENSP00000531546.1",
"transcript_support_level": null,
"aa_start": 660,
"aa_end": null,
"aa_length": 700,
"cds_start": 1978,
"cds_end": null,
"cds_length": 2103,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861487.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1975C>T",
"hgvs_p": "p.Leu659Phe",
"transcript": "ENST00000861485.1",
"protein_id": "ENSP00000531544.1",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 699,
"cds_start": 1975,
"cds_end": null,
"cds_length": 2100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861485.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1936C>T",
"hgvs_p": "p.Leu646Phe",
"transcript": "NM_001042704.2",
"protein_id": "NP_001036169.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 686,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001042704.2"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1936C>T",
"hgvs_p": "p.Leu646Phe",
"transcript": "ENST00000861477.1",
"protein_id": "ENSP00000531536.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 686,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861477.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1936C>T",
"hgvs_p": "p.Leu646Phe",
"transcript": "ENST00000861482.1",
"protein_id": "ENSP00000531541.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 686,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861482.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1936C>T",
"hgvs_p": "p.Leu646Phe",
"transcript": "ENST00000956816.1",
"protein_id": "ENSP00000626875.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 686,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956816.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1936C>T",
"hgvs_p": "p.Leu646Phe",
"transcript": "ENST00000956817.1",
"protein_id": "ENSP00000626876.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 686,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956817.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1936C>T",
"hgvs_p": "p.Leu646Phe",
"transcript": "ENST00000956818.1",
"protein_id": "ENSP00000626877.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 686,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956818.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1930C>T",
"hgvs_p": "p.Leu644Phe",
"transcript": "ENST00000861499.1",
"protein_id": "ENSP00000531558.1",
"transcript_support_level": null,
"aa_start": 644,
"aa_end": null,
"aa_length": 684,
"cds_start": 1930,
"cds_end": null,
"cds_length": 2055,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861499.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1927C>T",
"hgvs_p": "p.Leu643Phe",
"transcript": "ENST00000861500.1",
"protein_id": "ENSP00000531559.1",
"transcript_support_level": null,
"aa_start": 643,
"aa_end": null,
"aa_length": 683,
"cds_start": 1927,
"cds_end": null,
"cds_length": 2052,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861500.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1912C>T",
"hgvs_p": "p.Leu638Phe",
"transcript": "ENST00000861494.1",
"protein_id": "ENSP00000531553.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 678,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2037,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861494.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1909C>T",
"hgvs_p": "p.Leu637Phe",
"transcript": "ENST00000861486.1",
"protein_id": "ENSP00000531545.1",
"transcript_support_level": null,
"aa_start": 637,
"aa_end": null,
"aa_length": 677,
"cds_start": 1909,
"cds_end": null,
"cds_length": 2034,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861486.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1882C>T",
"hgvs_p": "p.Leu628Phe",
"transcript": "ENST00000861478.1",
"protein_id": "ENSP00000531537.1",
"transcript_support_level": null,
"aa_start": 628,
"aa_end": null,
"aa_length": 668,
"cds_start": 1882,
"cds_end": null,
"cds_length": 2007,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861478.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1879C>T",
"hgvs_p": "p.Leu627Phe",
"transcript": "ENST00000861490.1",
"protein_id": "ENSP00000531549.1",
"transcript_support_level": null,
"aa_start": 627,
"aa_end": null,
"aa_length": 667,
"cds_start": 1879,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861490.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1843C>T",
"hgvs_p": "p.Leu615Phe",
"transcript": "ENST00000861479.1",
"protein_id": "ENSP00000531538.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 655,
"cds_start": 1843,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861479.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1843C>T",
"hgvs_p": "p.Leu615Phe",
"transcript": "ENST00000861480.1",
"protein_id": "ENSP00000531539.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 655,
"cds_start": 1843,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861480.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1843C>T",
"hgvs_p": "p.Leu615Phe",
"transcript": "ENST00000861484.1",
"protein_id": "ENSP00000531543.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 655,
"cds_start": 1843,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861484.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1840C>T",
"hgvs_p": "p.Leu614Phe",
"transcript": "ENST00000861483.1",
"protein_id": "ENSP00000531542.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 654,
"cds_start": 1840,
"cds_end": null,
"cds_length": 1965,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861483.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKA",
"gene_hgnc_id": 2026,
"hgvs_c": "c.1822C>T",
"hgvs_p": "p.Leu608Phe",
"transcript": "ENST00000861501.1",
"protein_id": "ENSP00000531560.1",
"transcript_support_level": null,
"aa_start": 608,
"aa_end": null,
"aa_length": 648,
"cds_start": 1822,
"cds_end": null,
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}
],
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}