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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-161169143-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=161169143&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 161169143,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000367999.9",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.767C>T",
"hgvs_p": "p.Pro256Leu",
"transcript": "NM_001122764.3",
"protein_id": "NP_001116236.1",
"transcript_support_level": null,
"aa_start": 256,
"aa_end": null,
"aa_length": 477,
"cds_start": 767,
"cds_end": null,
"cds_length": 1434,
"cdna_start": 1022,
"cdna_end": null,
"cdna_length": 1733,
"mane_select": "ENST00000367999.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.767C>T",
"hgvs_p": "p.Pro256Leu",
"transcript": "ENST00000367999.9",
"protein_id": "ENSP00000356978.4",
"transcript_support_level": 1,
"aa_start": 256,
"aa_end": null,
"aa_length": 477,
"cds_start": 767,
"cds_end": null,
"cds_length": 1434,
"cdna_start": 1022,
"cdna_end": null,
"cdna_length": 1733,
"mane_select": "NM_001122764.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.767C>T",
"hgvs_p": "p.Pro256Leu",
"transcript": "ENST00000352210.9",
"protein_id": "ENSP00000343943.5",
"transcript_support_level": 1,
"aa_start": 256,
"aa_end": null,
"aa_length": 477,
"cds_start": 767,
"cds_end": null,
"cds_length": 1434,
"cdna_start": 977,
"cdna_end": null,
"cdna_length": 1686,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.767C>T",
"hgvs_p": "p.Pro256Leu",
"transcript": "NM_000309.5",
"protein_id": "NP_000300.1",
"transcript_support_level": null,
"aa_start": 256,
"aa_end": null,
"aa_length": 477,
"cds_start": 767,
"cds_end": null,
"cds_length": 1434,
"cdna_start": 961,
"cdna_end": null,
"cdna_length": 1672,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.767C>T",
"hgvs_p": "p.Pro256Leu",
"transcript": "NM_001365398.1",
"protein_id": "NP_001352327.1",
"transcript_support_level": null,
"aa_start": 256,
"aa_end": null,
"aa_length": 477,
"cds_start": 767,
"cds_end": null,
"cds_length": 1434,
"cdna_start": 877,
"cdna_end": null,
"cdna_length": 1588,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.668C>T",
"hgvs_p": "p.Pro223Leu",
"transcript": "NM_001350128.2",
"protein_id": "NP_001337057.1",
"transcript_support_level": null,
"aa_start": 223,
"aa_end": null,
"aa_length": 444,
"cds_start": 668,
"cds_end": null,
"cds_length": 1335,
"cdna_start": 923,
"cdna_end": null,
"cdna_length": 1634,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.767C>T",
"hgvs_p": "p.Pro256Leu",
"transcript": "NM_001365399.1",
"protein_id": "NP_001352328.1",
"transcript_support_level": null,
"aa_start": 256,
"aa_end": null,
"aa_length": 440,
"cds_start": 767,
"cds_end": null,
"cds_length": 1323,
"cdna_start": 1022,
"cdna_end": null,
"cdna_length": 1622,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.767C>T",
"hgvs_p": "p.Pro256Leu",
"transcript": "ENST00000652182.1",
"protein_id": "ENSP00000498884.1",
"transcript_support_level": null,
"aa_start": 256,
"aa_end": null,
"aa_length": 434,
"cds_start": 767,
"cds_end": null,
"cds_length": 1307,
"cdna_start": 986,
"cdna_end": null,
"cdna_length": 1526,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.470C>T",
"hgvs_p": "p.Pro157Leu",
"transcript": "ENST00000652103.1",
"protein_id": "ENSP00000498501.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 378,
"cds_start": 470,
"cds_end": null,
"cds_length": 1137,
"cdna_start": 471,
"cdna_end": null,
"cdna_length": 1176,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.359C>T",
"hgvs_p": "p.Pro120Leu",
"transcript": "NM_001350129.2",
"protein_id": "NP_001337058.1",
"transcript_support_level": null,
"aa_start": 120,
"aa_end": null,
"aa_length": 341,
"cds_start": 359,
"cds_end": null,
"cds_length": 1026,
"cdna_start": 1041,
"cdna_end": null,
"cdna_length": 1752,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.359C>T",
"hgvs_p": "p.Pro120Leu",
"transcript": "NM_001365400.1",
"protein_id": "NP_001352329.1",
"transcript_support_level": null,
"aa_start": 120,
"aa_end": null,
"aa_length": 341,
"cds_start": 359,
"cds_end": null,
"cds_length": 1026,
"cdna_start": 864,
"cdna_end": null,
"cdna_length": 1575,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.281C>T",
"hgvs_p": "p.Pro94Leu",
"transcript": "NM_001350130.2",
"protein_id": "NP_001337059.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 315,
"cds_start": 281,
"cds_end": null,
"cds_length": 948,
"cdna_start": 1054,
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"cdna_length": 1765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.281C>T",
"hgvs_p": "p.Pro94Leu",
"transcript": "NM_001350131.2",
"protein_id": "NP_001337060.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 315,
"cds_start": 281,
"cds_end": null,
"cds_length": 948,
"cdna_start": 879,
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"cdna_length": 1590,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.281C>T",
"hgvs_p": "p.Pro94Leu",
"transcript": "NM_001365401.1",
"protein_id": "NP_001352330.1",
"transcript_support_level": null,
"aa_start": 94,
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"cds_start": 281,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.203C>T",
"hgvs_p": "p.Pro68Leu",
"transcript": "ENST00000537523.5",
"protein_id": "ENSP00000439544.1",
"transcript_support_level": 3,
"aa_start": 68,
"aa_end": null,
"aa_length": 229,
"cds_start": 203,
"cds_end": null,
"cds_length": 690,
"cdna_start": 205,
"cdna_end": null,
"cdna_length": 734,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.896C>T",
"hgvs_p": "p.Pro299Leu",
"transcript": "XM_011509663.3",
"protein_id": "XP_011507965.1",
"transcript_support_level": null,
"aa_start": 299,
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"cdna_start": 1109,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.881C>T",
"hgvs_p": "p.Pro294Leu",
"transcript": "XM_011509664.2",
"protein_id": "XP_011507966.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 562,
"cds_start": 881,
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"cdna_start": 1093,
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"cdna_length": 2351,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.896C>T",
"hgvs_p": "p.Pro299Leu",
"transcript": "XM_011509665.3",
"protein_id": "XP_011507967.1",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 536,
"cds_start": 896,
"cds_end": null,
"cds_length": 1611,
"cdna_start": 1108,
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"mane_select": null,
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"feature": null
},
{
"aa_ref": "P",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
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"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.881C>T",
"hgvs_p": "p.Pro294Leu",
"transcript": "XM_047423569.1",
"protein_id": "XP_047279525.1",
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"aa_end": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
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"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.782C>T",
"hgvs_p": "p.Pro261Leu",
"transcript": "XM_011509667.3",
"protein_id": "XP_011507969.1",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
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"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.782C>T",
"hgvs_p": "p.Pro261Leu",
"transcript": "XM_011509668.3",
"protein_id": "XP_011507970.1",
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.782C>T",
"hgvs_p": "p.Pro261Leu",
"transcript": "XM_011509670.3",
"protein_id": "XP_011507972.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 529,
"cds_start": 782,
"cds_end": null,
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"cdna_start": 998,
"cdna_end": null,
"cdna_length": 2256,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPOX",
"gene_hgnc_id": 9280,
"hgvs_c": "c.782C>T",
"hgvs_p": "p.Pro261Leu",
"transcript": "XM_047423581.1",
"protein_id": "XP_047279537.1",
"transcript_support_level": null,
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}