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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-162775707-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=162775707&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 162775707,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_006182.4",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "NM_006182.4",
"protein_id": "NP_006173.2",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000367921.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006182.4"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000367921.8",
"protein_id": "ENSP00000356898.3",
"transcript_support_level": 1,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006182.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000367921.8"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000367922.7",
"protein_id": "ENSP00000356899.2",
"transcript_support_level": 1,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000367922.7"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1966A>G",
"hgvs_p": "p.Ile656Val",
"transcript": "ENST00000877159.1",
"protein_id": "ENSP00000547218.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 873,
"cds_start": 1966,
"cds_end": null,
"cds_length": 2622,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877159.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1966A>G",
"hgvs_p": "p.Ile656Val",
"transcript": "ENST00000966492.1",
"protein_id": "ENSP00000636551.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 873,
"cds_start": 1966,
"cds_end": null,
"cds_length": 2622,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966492.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1966A>G",
"hgvs_p": "p.Ile656Val",
"transcript": "ENST00000966493.1",
"protein_id": "ENSP00000636552.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 873,
"cds_start": 1966,
"cds_end": null,
"cds_length": 2622,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966493.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "NM_001014796.3",
"protein_id": "NP_001014796.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001014796.3"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "NM_001354982.2",
"protein_id": "NP_001341911.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354982.2"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "NM_001354983.2",
"protein_id": "NP_001341912.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354983.2"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000446985.6",
"protein_id": "ENSP00000400309.2",
"transcript_support_level": 3,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000446985.6"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877160.1",
"protein_id": "ENSP00000547219.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877160.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877161.1",
"protein_id": "ENSP00000547220.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877161.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877162.1",
"protein_id": "ENSP00000547221.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877162.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877163.1",
"protein_id": "ENSP00000547222.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877163.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877164.1",
"protein_id": "ENSP00000547223.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877164.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877166.1",
"protein_id": "ENSP00000547225.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877166.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877167.1",
"protein_id": "ENSP00000547226.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877167.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877169.1",
"protein_id": "ENSP00000547228.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877169.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877170.1",
"protein_id": "ENSP00000547229.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877170.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000877171.1",
"protein_id": "ENSP00000547230.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877171.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000966494.1",
"protein_id": "ENSP00000636553.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966494.1"
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DDR2",
"gene_hgnc_id": 2731,
"hgvs_c": "c.1912A>G",
"hgvs_p": "p.Ile638Val",
"transcript": "ENST00000966495.1",
"protein_id": "ENSP00000636554.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 855,
"cds_start": 1912,
"cds_end": null,
"cds_length": 2568,
"cdna_start": null,
"cdna_end": null,
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}
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}