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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-202729842-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=202729842&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 202729842,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001314042.2",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4362G>A",
"hgvs_p": "p.Glu1454Glu",
"transcript": "NM_006618.5",
"protein_id": "NP_006609.3",
"transcript_support_level": null,
"aa_start": 1454,
"aa_end": null,
"aa_length": 1544,
"cds_start": 4362,
"cds_end": null,
"cds_length": 4635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000367265.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006618.5"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4362G>A",
"hgvs_p": "p.Glu1454Glu",
"transcript": "ENST00000367265.9",
"protein_id": "ENSP00000356234.3",
"transcript_support_level": 1,
"aa_start": 1454,
"aa_end": null,
"aa_length": 1544,
"cds_start": 4362,
"cds_end": null,
"cds_length": 4635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006618.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000367265.9"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4470G>A",
"hgvs_p": "p.Glu1490Glu",
"transcript": "ENST00000367264.7",
"protein_id": "ENSP00000356233.2",
"transcript_support_level": 1,
"aa_start": 1490,
"aa_end": null,
"aa_length": 1580,
"cds_start": 4470,
"cds_end": null,
"cds_length": 4743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000367264.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "n.1368G>A",
"hgvs_p": null,
"transcript": "ENST00000472822.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000472822.6"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4470G>A",
"hgvs_p": "p.Glu1490Glu",
"transcript": "NM_001314042.2",
"protein_id": "NP_001300971.1",
"transcript_support_level": null,
"aa_start": 1490,
"aa_end": null,
"aa_length": 1580,
"cds_start": 4470,
"cds_end": null,
"cds_length": 4743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001314042.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4380G>A",
"hgvs_p": "p.Glu1460Glu",
"transcript": "ENST00000949534.1",
"protein_id": "ENSP00000619593.1",
"transcript_support_level": null,
"aa_start": 1460,
"aa_end": null,
"aa_length": 1550,
"cds_start": 4380,
"cds_end": null,
"cds_length": 4653,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949534.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4356G>A",
"hgvs_p": "p.Glu1452Glu",
"transcript": "ENST00000939933.1",
"protein_id": "ENSP00000609992.1",
"transcript_support_level": null,
"aa_start": 1452,
"aa_end": null,
"aa_length": 1542,
"cds_start": 4356,
"cds_end": null,
"cds_length": 4629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939933.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4347G>A",
"hgvs_p": "p.Glu1449Glu",
"transcript": "NM_001399817.1",
"protein_id": "NP_001386746.1",
"transcript_support_level": null,
"aa_start": 1449,
"aa_end": null,
"aa_length": 1539,
"cds_start": 4347,
"cds_end": null,
"cds_length": 4620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001399817.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4347G>A",
"hgvs_p": "p.Glu1449Glu",
"transcript": "ENST00000648056.1",
"protein_id": "ENSP00000497113.1",
"transcript_support_level": null,
"aa_start": 1449,
"aa_end": null,
"aa_length": 1539,
"cds_start": 4347,
"cds_end": null,
"cds_length": 4620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648056.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4362G>A",
"hgvs_p": "p.Glu1454Glu",
"transcript": "ENST00000648338.1",
"protein_id": "ENSP00000497564.1",
"transcript_support_level": null,
"aa_start": 1454,
"aa_end": null,
"aa_length": 1517,
"cds_start": 4362,
"cds_end": null,
"cds_length": 4554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648338.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4362G>A",
"hgvs_p": "p.Glu1454Glu",
"transcript": "ENST00000648473.1",
"protein_id": "ENSP00000497743.1",
"transcript_support_level": null,
"aa_start": 1454,
"aa_end": null,
"aa_length": 1505,
"cds_start": 4362,
"cds_end": null,
"cds_length": 4518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648473.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4239G>A",
"hgvs_p": "p.Glu1413Glu",
"transcript": "ENST00000648469.1",
"protein_id": "ENSP00000497827.1",
"transcript_support_level": null,
"aa_start": 1413,
"aa_end": null,
"aa_length": 1503,
"cds_start": 4239,
"cds_end": null,
"cds_length": 4512,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648469.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4227G>A",
"hgvs_p": "p.Glu1409Glu",
"transcript": "NM_001347591.2",
"protein_id": "NP_001334520.1",
"transcript_support_level": null,
"aa_start": 1409,
"aa_end": null,
"aa_length": 1499,
"cds_start": 4227,
"cds_end": null,
"cds_length": 4500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001347591.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4227G>A",
"hgvs_p": "p.Glu1409Glu",
"transcript": "ENST00000650569.1",
"protein_id": "ENSP00000497671.1",
"transcript_support_level": null,
"aa_start": 1409,
"aa_end": null,
"aa_length": 1499,
"cds_start": 4227,
"cds_end": null,
"cds_length": 4500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000650569.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4221G>A",
"hgvs_p": "p.Glu1407Glu",
"transcript": "ENST00000939935.1",
"protein_id": "ENSP00000609994.1",
"transcript_support_level": null,
"aa_start": 1407,
"aa_end": null,
"aa_length": 1497,
"cds_start": 4221,
"cds_end": null,
"cds_length": 4494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939935.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4203G>A",
"hgvs_p": "p.Glu1401Glu",
"transcript": "ENST00000939934.1",
"protein_id": "ENSP00000609993.1",
"transcript_support_level": null,
"aa_start": 1401,
"aa_end": null,
"aa_length": 1491,
"cds_start": 4203,
"cds_end": null,
"cds_length": 4476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939934.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4191G>A",
"hgvs_p": "p.Glu1397Glu",
"transcript": "ENST00000939938.1",
"protein_id": "ENSP00000609997.1",
"transcript_support_level": null,
"aa_start": 1397,
"aa_end": null,
"aa_length": 1487,
"cds_start": 4191,
"cds_end": null,
"cds_length": 4464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939938.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4239G>A",
"hgvs_p": "p.Glu1413Glu",
"transcript": "ENST00000649770.1",
"protein_id": "ENSP00000497288.1",
"transcript_support_level": null,
"aa_start": 1413,
"aa_end": null,
"aa_length": 1472,
"cds_start": 4239,
"cds_end": null,
"cds_length": 4419,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649770.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.4020G>A",
"hgvs_p": "p.Glu1340Glu",
"transcript": "ENST00000939936.1",
"protein_id": "ENSP00000609995.1",
"transcript_support_level": null,
"aa_start": 1340,
"aa_end": null,
"aa_length": 1430,
"cds_start": 4020,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939936.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.3990G>A",
"hgvs_p": "p.Glu1330Glu",
"transcript": "ENST00000939937.1",
"protein_id": "ENSP00000609996.1",
"transcript_support_level": null,
"aa_start": 1330,
"aa_end": null,
"aa_length": 1420,
"cds_start": 3990,
"cds_end": null,
"cds_length": 4263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939937.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.3996G>A",
"hgvs_p": "p.Glu1332Glu",
"transcript": "XM_011509090.4",
"protein_id": "XP_011507392.1",
"transcript_support_level": null,
"aa_start": 1332,
"aa_end": null,
"aa_length": 1422,
"cds_start": 3996,
"cds_end": null,
"cds_length": 4269,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011509090.4"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM5B",
"gene_hgnc_id": 18039,
"hgvs_c": "c.3996G>A",
"hgvs_p": "p.Glu1332Glu",
"transcript": "XM_011509091.3",
"protein_id": "XP_011507393.1",
"transcript_support_level": null,
"aa_start": 1332,
"aa_end": null,
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{
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],
"clinvar_disease": "not provided",
"clinvar_classification": "Likely benign",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "LB:1",
"phenotype_combined": "not provided",
"pathogenicity_classification_combined": "Likely benign",
"custom_annotations": null
}
],
"message": null
}