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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-67237570-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=67237570&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 67237570,
"ref": "C",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000347310.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.1045+768C>A",
"hgvs_p": null,
"transcript": "NM_144701.3",
"protein_id": "NP_653302.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 629,
"cds_start": -4,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2858,
"mane_select": "ENST00000347310.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.1045+768C>A",
"hgvs_p": null,
"transcript": "ENST00000347310.10",
"protein_id": "ENSP00000321345.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 629,
"cds_start": -4,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2858,
"mane_select": "NM_144701.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.280+768C>A",
"hgvs_p": null,
"transcript": "ENST00000425614.3",
"protein_id": "ENSP00000387640.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 374,
"cds_start": -4,
"cds_end": null,
"cds_length": 1125,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1295,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "n.190+17840C>A",
"hgvs_p": null,
"transcript": "ENST00000473881.2",
"protein_id": "ENSP00000486667.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1507,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "n.*506+768C>A",
"hgvs_p": null,
"transcript": "ENST00000637002.1",
"protein_id": "ENSP00000490340.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2208,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.956-2609C>A",
"hgvs_p": null,
"transcript": "ENST00000697164.1",
"protein_id": "ENSP00000513153.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 599,
"cds_start": -4,
"cds_end": null,
"cds_length": 1800,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1800,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.742+768C>A",
"hgvs_p": null,
"transcript": "ENST00000697165.1",
"protein_id": "ENSP00000513154.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 528,
"cds_start": -4,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1587,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.1045+768C>A",
"hgvs_p": null,
"transcript": "ENST00000697163.1",
"protein_id": "ENSP00000513152.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 414,
"cds_start": -4,
"cds_end": null,
"cds_length": 1245,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1272,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.956-2609C>A",
"hgvs_p": null,
"transcript": "ENST00000697230.1",
"protein_id": "ENSP00000513197.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 384,
"cds_start": -4,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "c.955+17840C>A",
"hgvs_p": null,
"transcript": "ENST00000697154.1",
"protein_id": "ENSP00000513143.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 320,
"cds_start": -4,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1055,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "n.*549+768C>A",
"hgvs_p": null,
"transcript": "ENST00000697148.1",
"protein_id": "ENSP00000513137.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 6,
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"gene_symbol": "IL23R",
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"hgvs_c": "n.*359+768C>A",
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"transcript": "ENST00000697149.1",
"protein_id": "ENSP00000513138.1",
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"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 7,
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"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "n.1045+768C>A",
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"transcript": "ENST00000697150.1",
"protein_id": "ENSP00000513139.1",
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"aa_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
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"gene_symbol": "IL23R",
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"hgvs_c": "n.1045+768C>A",
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"transcript": "ENST00000697151.1",
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},
{
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],
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"transcript": "ENST00000697152.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 5,
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"gene_symbol": "IL23R",
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"hgvs_c": "n.*269+17840C>A",
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},
{
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],
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"gene_symbol": "IL23R",
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"transcript": "ENST00000697155.1",
"protein_id": "ENSP00000513144.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "n.1045+768C>A",
"hgvs_p": null,
"transcript": "ENST00000697156.1",
"protein_id": "ENSP00000513145.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 6,
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"gene_symbol": "IL23R",
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"hgvs_c": "n.*242+768C>A",
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},
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],
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},
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],
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},
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"strand": true,
"consequences": [
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],
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"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "IL23R",
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"hgvs_c": "n.955+17840C>A",
"hgvs_p": null,
"transcript": "ENST00000697160.1",
"protein_id": "ENSP00000513149.1",
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "IL23R",
"gene_hgnc_id": 19100,
"hgvs_c": "n.*56+768C>A",
"hgvs_p": null,
"transcript": "ENST00000697161.1",
"protein_id": "ENSP00000513150.1",
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"mane_select": null,
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},
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