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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-7809988-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=7809988&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 7809988,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "ENST00000377532.8",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001377275.1",
"protein_id": "NP_001364204.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1210,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3633,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6365,
"mane_select": "ENST00000377532.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "ENST00000377532.8",
"protein_id": "ENSP00000366755.3",
"transcript_support_level": 1,
"aa_start": 446,
"aa_end": null,
"aa_length": 1210,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3633,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6365,
"mane_select": "NM_001377275.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1335T>C",
"hgvs_p": "p.Ser445Ser",
"transcript": "ENST00000361923.2",
"protein_id": "ENSP00000355031.2",
"transcript_support_level": 1,
"aa_start": 445,
"aa_end": null,
"aa_length": 1201,
"cds_start": 1335,
"cds_end": null,
"cds_length": 3606,
"cdna_start": 1510,
"cdna_end": null,
"cdna_length": 6203,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "ENST00000614998.4",
"protein_id": "ENSP00000479223.1",
"transcript_support_level": 1,
"aa_start": 446,
"aa_end": null,
"aa_length": 1191,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3576,
"cdna_start": 1602,
"cdna_end": null,
"cdna_length": 6261,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001289862.2",
"protein_id": "NP_001276791.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1210,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3633,
"cdna_start": 1602,
"cdna_end": null,
"cdna_length": 6319,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "ENST00000613533.4",
"protein_id": "ENSP00000482093.1",
"transcript_support_level": 5,
"aa_start": 446,
"aa_end": null,
"aa_length": 1210,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3633,
"cdna_start": 1602,
"cdna_end": null,
"cdna_length": 6318,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1335T>C",
"hgvs_p": "p.Ser445Ser",
"transcript": "NM_001438696.1",
"protein_id": "NP_001425625.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 1209,
"cds_start": 1335,
"cds_end": null,
"cds_length": 3630,
"cdna_start": 1645,
"cdna_end": null,
"cdna_length": 6362,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001438697.1",
"protein_id": "NP_001425626.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1209,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3630,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6362,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1335T>C",
"hgvs_p": "p.Ser445Ser",
"transcript": "NM_001438698.1",
"protein_id": "NP_001425627.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 1208,
"cds_start": 1335,
"cds_end": null,
"cds_length": 3627,
"cdna_start": 1686,
"cdna_end": null,
"cdna_length": 6400,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001438700.1",
"protein_id": "NP_001425629.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1203,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3612,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001438701.1",
"protein_id": "NP_001425630.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1203,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3612,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6411,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001377276.1",
"protein_id": "NP_001364205.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1202,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3609,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6341,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001438702.1",
"protein_id": "NP_001425631.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1202,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3609,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6408,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1335T>C",
"hgvs_p": "p.Ser445Ser",
"transcript": "NM_016831.4",
"protein_id": "NP_058515.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 1201,
"cds_start": 1335,
"cds_end": null,
"cds_length": 3606,
"cdna_start": 1737,
"cdna_end": null,
"cdna_length": 6430,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001438703.1",
"protein_id": "NP_001425632.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1196,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3591,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6390,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001438704.1",
"protein_id": "NP_001425633.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1195,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3588,
"cdna_start": 1648,
"cdna_end": null,
"cdna_length": 6387,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1335T>C",
"hgvs_p": "p.Ser445Ser",
"transcript": "NM_001438705.1",
"protein_id": "NP_001425634.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 1195,
"cds_start": 1335,
"cds_end": null,
"cds_length": 3588,
"cdna_start": 1645,
"cdna_end": null,
"cdna_length": 6387,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1335T>C",
"hgvs_p": "p.Ser445Ser",
"transcript": "NM_001438706.1",
"protein_id": "NP_001425635.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 1194,
"cds_start": 1335,
"cds_end": null,
"cds_length": 3585,
"cdna_start": 1645,
"cdna_end": null,
"cdna_length": 6384,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001289861.2",
"protein_id": "NP_001276790.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1191,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3576,
"cdna_start": 1740,
"cdna_end": null,
"cdna_length": 6400,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "NM_001289863.3",
"protein_id": "NP_001276792.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1184,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3555,
"cdna_start": 1740,
"cdna_end": null,
"cdna_length": 6379,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.381T>C",
"hgvs_p": "p.Ser127Ser",
"transcript": "NM_001289864.3",
"protein_id": "NP_001276793.1",
"transcript_support_level": null,
"aa_start": 127,
"aa_end": null,
"aa_length": 890,
"cds_start": 381,
"cds_end": null,
"cds_length": 2673,
"cdna_start": 1801,
"cdna_end": null,
"cdna_length": 6515,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "XM_047433434.1",
"protein_id": "XP_047289390.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 1210,
"cds_start": 1338,
"cds_end": null,
"cds_length": 3633,
"cdna_start": 1827,
"cdna_end": null,
"cdna_length": 6544,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PER3",
"gene_hgnc_id": 8847,
"hgvs_c": "c.1338T>C",
"hgvs_p": "p.Ser446Ser",
"transcript": "XM_047433435.1",
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}
],
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}