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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-90917078-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=90917078&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 90917078,
"ref": "C",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000337393.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3792-88G>C",
"hgvs_p": null,
"transcript": "NM_201269.3",
"protein_id": "NP_958357.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1327,
"cds_start": -4,
"cds_end": null,
"cds_length": 3984,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5541,
"mane_select": "ENST00000337393.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3792-88G>C",
"hgvs_p": null,
"transcript": "ENST00000337393.10",
"protein_id": "ENSP00000337008.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1327,
"cds_start": -4,
"cds_end": null,
"cds_length": 3984,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5541,
"mane_select": "NM_201269.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.126-88G>C",
"hgvs_p": null,
"transcript": "ENST00000347275.9",
"protein_id": "ENSP00000340828.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 105,
"cds_start": -4,
"cds_end": null,
"cds_length": 318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2036,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3915-88G>C",
"hgvs_p": null,
"transcript": "NM_001437612.1",
"protein_id": "NP_001424541.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1368,
"cds_start": -4,
"cds_end": null,
"cds_length": 4107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6487,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3915-88G>C",
"hgvs_p": null,
"transcript": "NM_001437613.1",
"protein_id": "NP_001424542.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1368,
"cds_start": -4,
"cds_end": null,
"cds_length": 4107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5965,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3792-88G>C",
"hgvs_p": null,
"transcript": "NM_001437610.1",
"protein_id": "NP_001424539.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1327,
"cds_start": -4,
"cds_end": null,
"cds_length": 3984,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5706,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3792-88G>C",
"hgvs_p": null,
"transcript": "NM_001437611.1",
"protein_id": "NP_001424540.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1327,
"cds_start": -4,
"cds_end": null,
"cds_length": 3984,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6364,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3792-88G>C",
"hgvs_p": null,
"transcript": "ENST00000370440.5",
"protein_id": "ENSP00000359469.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1327,
"cds_start": -4,
"cds_end": null,
"cds_length": 3984,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5702,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.126-88G>C",
"hgvs_p": null,
"transcript": "NM_016620.4",
"protein_id": "NP_057704.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 105,
"cds_start": -4,
"cds_end": null,
"cds_length": 318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2062,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.126-88G>C",
"hgvs_p": null,
"transcript": "NM_032186.5",
"protein_id": "NP_115562.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 105,
"cds_start": -4,
"cds_end": null,
"cds_length": 318,
"cdna_start": null,
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"cdna_length": 1897,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
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"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.126-88G>C",
"hgvs_p": null,
"transcript": "ENST00000361321.5",
"protein_id": "ENSP00000354659.5",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
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"gene_symbol": "ZNF644",
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"hgvs_c": "n.251-88G>C",
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"transcript": "ENST00000467231.5",
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},
{
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"strand": false,
"consequences": [
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],
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"gene_symbol": "ZNF644",
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"hgvs_c": "n.225-88G>C",
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"transcript": "ENST00000479798.1",
"protein_id": null,
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},
{
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"strand": false,
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],
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"hgvs_c": "n.341-88G>C",
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"protein_id": null,
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},
{
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],
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},
{
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"consequences": [
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],
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"gene_symbol": "ZNF644",
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"hgvs_c": "c.3915-88G>C",
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"transcript": "XM_011542258.4",
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},
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],
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},
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],
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"intron_rank": 6,
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"gene_symbol": "ZNF644",
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"hgvs_c": "c.3915-88G>C",
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"transcript": "XM_047431934.1",
"protein_id": "XP_047287890.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 7,
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"gene_symbol": "ZNF644",
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"hgvs_c": "c.3915-88G>C",
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],
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],
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},
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],
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"gene_symbol": "ZNF644",
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"hgvs_c": "c.3792-88G>C",
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"transcript": "XM_017002489.3",
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"feature": null
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZNF644",
"gene_hgnc_id": 29222,
"hgvs_c": "c.3792-88G>C",
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"transcript": "XM_047431962.1",
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},
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}
],
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}