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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-109891375-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=109891375&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 109891375,
"ref": "T",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000502935.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.415+347A>T",
"hgvs_p": null,
"transcript": "NM_020383.4",
"protein_id": "NP_065116.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 666,
"cds_start": -4,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2497,
"mane_select": "ENST00000502935.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.415+347A>T",
"hgvs_p": null,
"transcript": "ENST00000502935.6",
"protein_id": "ENSP00000421566.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 666,
"cds_start": -4,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2497,
"mane_select": "NM_020383.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.415+347A>T",
"hgvs_p": null,
"transcript": "ENST00000322238.12",
"protein_id": "ENSP00000324011.8",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 642,
"cds_start": -4,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2467,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.191-2780A>T",
"hgvs_p": null,
"transcript": "ENST00000488118.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4384,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.415+347A>T",
"hgvs_p": null,
"transcript": "NM_001324133.2",
"protein_id": "NP_001311062.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 695,
"cds_start": -4,
"cds_end": null,
"cds_length": 2088,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2555,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.400+347A>T",
"hgvs_p": null,
"transcript": "NM_001324136.1",
"protein_id": "NP_001311065.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 661,
"cds_start": -4,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2754,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.415+347A>T",
"hgvs_p": null,
"transcript": "NM_001324135.2",
"protein_id": "NP_001311064.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 649,
"cds_start": -4,
"cds_end": null,
"cds_length": 1950,
"cdna_start": null,
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"cdna_length": 2446,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.415+347A>T",
"hgvs_p": null,
"transcript": "NM_001167604.2",
"protein_id": "NP_001161076.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 642,
"cds_start": -4,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.286+347A>T",
"hgvs_p": null,
"transcript": "NM_001324132.2",
"protein_id": "NP_001311061.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2408,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.73+347A>T",
"hgvs_p": null,
"transcript": "NM_001324128.2",
"protein_id": "NP_001311057.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 3,
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"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.73+347A>T",
"hgvs_p": null,
"transcript": "ENST00000369683.5",
"protein_id": "ENSP00000358697.1",
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 21,
"intron_rank": 6,
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"gene_symbol": "XPNPEP1",
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"transcript": "NM_001324131.2",
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},
{
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"strand": false,
"consequences": [
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],
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"gene_symbol": "XPNPEP1",
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"hgvs_c": "c.-107-2780A>T",
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"transcript": "NM_001324134.2",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "XPNPEP1",
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"hgvs_c": "c.286+347A>T",
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"transcript": "ENST00000403138.6",
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},
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],
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"gene_symbol": "XPNPEP1",
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"hgvs_c": "c.286+347A>T",
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"transcript": "ENST00000423625.1",
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},
{
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],
"exon_rank": null,
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"exon_count": 9,
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"gene_symbol": "XPNPEP1",
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},
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],
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"gene_symbol": "XPNPEP1",
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},
{
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"consequences": [
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],
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"intron_rank": 5,
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"gene_symbol": "XPNPEP1",
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"hgvs_c": "n.422+347A>T",
"hgvs_p": null,
"transcript": "ENST00000451592.5",
"protein_id": null,
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},
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"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
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"hgvs_c": "n.192-2780A>T",
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},
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],
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},
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],
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},
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"consequences": [
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],
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"intron_rank": 2,
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"gene_symbol": "XPNPEP1",
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"hgvs_c": "n.201+347A>T",
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"transcript": "ENST00000505255.5",
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.406+347A>T",
"hgvs_p": null,
"transcript": "ENST00000506777.5",
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},
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"protein_coding": false,
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}