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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-110878270-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=110878270&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 12,
"criteria": [
"BP4_Strong",
"BA1"
],
"effects": [
"intron_variant"
],
"gene_symbol": "PDCD4",
"hgnc_id": 8763,
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"inheritance_mode": "AR",
"pathogenic_score": 0,
"score": -12,
"transcript": "NM_014456.5",
"verdict": "Benign"
}
],
"acmg_classification": "Benign",
"acmg_criteria": "BP4_Strong,BA1",
"acmg_score": -12,
"allele_count_reference_population": 84832,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "G",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.91,
"chr": "10",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": "Benign",
"computational_score_selected": -0.9100000262260437,
"computational_source_selected": "BayesDel_noAF",
"consequences": [
{
"aa_alt": null,
"aa_end": null,
"aa_length": 469,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3481,
"cdna_start": null,
"cds_end": null,
"cds_length": 1410,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_014456.5",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000280154.12",
"protein_coding": true,
"protein_id": "NP_055271.2",
"strand": true,
"transcript": "NM_014456.5",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 469,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 3481,
"cdna_start": null,
"cds_end": null,
"cds_length": 1410,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000280154.12",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_014456.5",
"protein_coding": true,
"protein_id": "ENSP00000280154.7",
"strand": true,
"transcript": "ENST00000280154.12",
"transcript_support_level": 1
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 458,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3697,
"cdna_start": null,
"cds_end": null,
"cds_length": 1377,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000393104.6",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.10+1517T>G",
"hgvs_p": null,
"intron_rank": 3,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000376816.2",
"strand": true,
"transcript": "ENST00000393104.6",
"transcript_support_level": 1
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 484,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2257,
"cdna_start": null,
"cds_end": null,
"cds_length": 1455,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000888009.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000558068.1",
"strand": true,
"transcript": "ENST00000888009.1",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 477,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2246,
"cdna_start": null,
"cds_end": null,
"cds_length": 1434,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000963371.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000633430.1",
"strand": true,
"transcript": "ENST00000963371.1",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 469,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3369,
"cdna_start": null,
"cds_end": null,
"cds_length": 1410,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000888008.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000558067.1",
"strand": true,
"transcript": "ENST00000888008.1",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 469,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2269,
"cdna_start": null,
"cds_end": null,
"cds_length": 1410,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000888011.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000558070.1",
"strand": true,
"transcript": "ENST00000888011.1",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 469,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2294,
"cdna_start": null,
"cds_end": null,
"cds_length": 1410,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000888012.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000558071.1",
"strand": true,
"transcript": "ENST00000888012.1",
"transcript_support_level": null
},
{
"aa_alt": null,
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"aa_length": 469,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2282,
"cdna_start": null,
"cds_end": null,
"cds_length": 1410,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000888013.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000558072.1",
"strand": true,
"transcript": "ENST00000888013.1",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 469,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2672,
"cdna_start": null,
"cds_end": null,
"cds_length": 1410,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000888015.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000558074.1",
"strand": true,
"transcript": "ENST00000888015.1",
"transcript_support_level": null
},
{
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"biotype": "protein_coding",
"canonical": false,
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"cdna_start": null,
"cds_end": null,
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"cds_start": null,
"consequences": [
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],
"exon_count": 12,
"exon_rank": null,
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"feature": "ENST00000888016.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
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"mane_plus": null,
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"protein_coding": true,
"protein_id": "ENSP00000558075.1",
"strand": true,
"transcript": "ENST00000888016.1",
"transcript_support_level": null
},
{
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"biotype": "protein_coding",
"canonical": false,
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"cdna_length": 2351,
"cdna_start": null,
"cds_end": null,
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"consequences": [
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],
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"feature": "ENST00000963374.1",
"gene_hgnc_id": 8763,
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"protein_id": "ENSP00000633433.1",
"strand": true,
"transcript": "ENST00000963374.1",
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},
{
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],
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"feature": "ENST00000888007.1",
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},
{
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"consequences": [
"intron_variant"
],
"exon_count": 12,
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"feature": "ENST00000888010.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
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"mane_plus": null,
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"protein_coding": true,
"protein_id": "ENSP00000558069.1",
"strand": true,
"transcript": "ENST00000888010.1",
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},
{
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],
"exon_count": 13,
"exon_rank": null,
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"feature": "NM_145341.4",
"gene_hgnc_id": 8763,
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"mane_plus": null,
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"protein_coding": true,
"protein_id": "NP_663314.1",
"strand": true,
"transcript": "NM_145341.4",
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},
{
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"biotype": "protein_coding",
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"cds_start": null,
"consequences": [
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],
"exon_count": 12,
"exon_rank": null,
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"feature": "NM_001199492.2",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
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"mane_plus": null,
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"protein_coding": true,
"protein_id": "NP_001186421.1",
"strand": true,
"transcript": "NM_001199492.2",
"transcript_support_level": null
},
{
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"cds_start": null,
"consequences": [
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],
"exon_count": 12,
"exon_rank": null,
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"feature": "ENST00000888014.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
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"protein_coding": true,
"protein_id": "ENSP00000558073.1",
"strand": true,
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},
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],
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"feature": "ENST00000919434.1",
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},
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],
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"feature": "ENST00000919435.1",
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},
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"consequences": [
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],
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"feature": "ENST00000963377.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
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"mane_plus": null,
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"protein_coding": true,
"protein_id": "ENSP00000633436.1",
"strand": true,
"transcript": "ENST00000963377.1",
"transcript_support_level": null
},
{
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"biotype": "protein_coding",
"canonical": false,
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"cds_end": null,
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"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000963375.1",
"gene_hgnc_id": 8763,
"gene_symbol": "PDCD4",
"hgvs_c": "c.43+2200T>G",
"hgvs_p": null,
"intron_rank": 2,
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"mane_plus": null,
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"protein_coding": true,
"protein_id": "ENSP00000633434.1",
"strand": true,
"transcript": "ENST00000963375.1",
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},
{
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"cdna_end": null,
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