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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-24543956-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=24543956&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 24543956,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000376454.8",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4686C>A",
"hgvs_p": "p.Thr1562Thr",
"transcript": "NM_019590.5",
"protein_id": "NP_062536.2",
"transcript_support_level": null,
"aa_start": 1562,
"aa_end": null,
"aa_length": 1943,
"cds_start": 4686,
"cds_end": null,
"cds_length": 5832,
"cdna_start": 4742,
"cdna_end": null,
"cdna_length": 7407,
"mane_select": "ENST00000376454.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4686C>A",
"hgvs_p": "p.Thr1562Thr",
"transcript": "ENST00000376454.8",
"protein_id": "ENSP00000365637.3",
"transcript_support_level": 1,
"aa_start": 1562,
"aa_end": null,
"aa_length": 1943,
"cds_start": 4686,
"cds_end": null,
"cds_length": 5832,
"cdna_start": 4742,
"cdna_end": null,
"cdna_length": 7407,
"mane_select": "NM_019590.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.3735C>A",
"hgvs_p": "p.Thr1245Thr",
"transcript": "ENST00000376451.4",
"protein_id": "ENSP00000365634.2",
"transcript_support_level": 1,
"aa_start": 1245,
"aa_end": null,
"aa_length": 1465,
"cds_start": 3735,
"cds_end": null,
"cds_length": 4398,
"cdna_start": 3995,
"cdna_end": null,
"cdna_length": 7383,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.3505-1025C>A",
"hgvs_p": null,
"transcript": "ENST00000376452.7",
"protein_id": "ENSP00000365635.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1374,
"cds_start": -4,
"cds_end": null,
"cds_length": 4125,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6052,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.3430-1025C>A",
"hgvs_p": null,
"transcript": "ENST00000458595.5",
"protein_id": "ENSP00000392625.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1349,
"cds_start": -4,
"cds_end": null,
"cds_length": 4050,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5977,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.3175-1025C>A",
"hgvs_p": null,
"transcript": "ENST00000376462.5",
"protein_id": "ENSP00000365645.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1264,
"cds_start": -4,
"cds_end": null,
"cds_length": 3795,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6123,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.2662-1025C>A",
"hgvs_p": null,
"transcript": "ENST00000307544.10",
"protein_id": "ENSP00000302343.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 932,
"cds_start": -4,
"cds_end": null,
"cds_length": 2799,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3281,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.2584-1025C>A",
"hgvs_p": null,
"transcript": "ENST00000396445.5",
"protein_id": "ENSP00000379722.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 906,
"cds_start": -4,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5706,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.2464-1025C>A",
"hgvs_p": null,
"transcript": "ENST00000396446.5",
"protein_id": "ENSP00000379723.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 866,
"cds_start": -4,
"cds_end": null,
"cds_length": 2601,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3059,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4449C>A",
"hgvs_p": "p.Thr1483Thr",
"transcript": "ENST00000696626.1",
"protein_id": "ENSP00000512763.1",
"transcript_support_level": null,
"aa_start": 1483,
"aa_end": null,
"aa_length": 1864,
"cds_start": 4449,
"cds_end": null,
"cds_length": 5595,
"cdna_start": 5806,
"cdna_end": null,
"cdna_length": 8471,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.1332C>A",
"hgvs_p": "p.Thr444Thr",
"transcript": "ENST00000635163.1",
"protein_id": "ENSP00000489575.1",
"transcript_support_level": 5,
"aa_start": 444,
"aa_end": null,
"aa_length": 451,
"cds_start": 1332,
"cds_end": null,
"cds_length": 1356,
"cdna_start": 1334,
"cdna_end": null,
"cdna_length": 1358,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4683C>A",
"hgvs_p": "p.Thr1561Thr",
"transcript": "XM_047425494.1",
"protein_id": "XP_047281450.1",
"transcript_support_level": null,
"aa_start": 1561,
"aa_end": null,
"aa_length": 1942,
"cds_start": 4683,
"cds_end": null,
"cds_length": 5829,
"cdna_start": 4739,
"cdna_end": null,
"cdna_length": 7404,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4653C>A",
"hgvs_p": "p.Thr1551Thr",
"transcript": "XM_047425495.1",
"protein_id": "XP_047281451.1",
"transcript_support_level": null,
"aa_start": 1551,
"aa_end": null,
"aa_length": 1932,
"cds_start": 4653,
"cds_end": null,
"cds_length": 5799,
"cdna_start": 4709,
"cdna_end": null,
"cdna_length": 7374,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4581C>A",
"hgvs_p": "p.Thr1527Thr",
"transcript": "XM_017016417.2",
"protein_id": "XP_016871906.1",
"transcript_support_level": null,
"aa_start": 1527,
"aa_end": null,
"aa_length": 1908,
"cds_start": 4581,
"cds_end": null,
"cds_length": 5727,
"cdna_start": 4637,
"cdna_end": null,
"cdna_length": 7302,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4578C>A",
"hgvs_p": "p.Thr1526Thr",
"transcript": "XM_047425496.1",
"protein_id": "XP_047281452.1",
"transcript_support_level": null,
"aa_start": 1526,
"aa_end": null,
"aa_length": 1907,
"cds_start": 4578,
"cds_end": null,
"cds_length": 5724,
"cdna_start": 4634,
"cdna_end": null,
"cdna_length": 7299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4566C>A",
"hgvs_p": "p.Thr1522Thr",
"transcript": "XM_047425497.1",
"protein_id": "XP_047281453.1",
"transcript_support_level": null,
"aa_start": 1522,
"aa_end": null,
"aa_length": 1903,
"cds_start": 4566,
"cds_end": null,
"cds_length": 5712,
"cdna_start": 4622,
"cdna_end": null,
"cdna_length": 7287,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4548C>A",
"hgvs_p": "p.Thr1516Thr",
"transcript": "XM_047425498.1",
"protein_id": "XP_047281454.1",
"transcript_support_level": null,
"aa_start": 1516,
"aa_end": null,
"aa_length": 1897,
"cds_start": 4548,
"cds_end": null,
"cds_length": 5694,
"cdna_start": 4604,
"cdna_end": null,
"cdna_length": 7269,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4461C>A",
"hgvs_p": "p.Thr1487Thr",
"transcript": "XM_047425499.1",
"protein_id": "XP_047281455.1",
"transcript_support_level": null,
"aa_start": 1487,
"aa_end": null,
"aa_length": 1868,
"cds_start": 4461,
"cds_end": null,
"cds_length": 5607,
"cdna_start": 4517,
"cdna_end": null,
"cdna_length": 7182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4458C>A",
"hgvs_p": "p.Thr1486Thr",
"transcript": "XM_047425500.1",
"protein_id": "XP_047281456.1",
"transcript_support_level": null,
"aa_start": 1486,
"aa_end": null,
"aa_length": 1867,
"cds_start": 4458,
"cds_end": null,
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"cdna_start": 4514,
"cdna_end": null,
"cdna_length": 7179,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4236C>A",
"hgvs_p": "p.Thr1412Thr",
"transcript": "XM_017016420.2",
"protein_id": "XP_016871909.1",
"transcript_support_level": null,
"aa_start": 1412,
"aa_end": null,
"aa_length": 1793,
"cds_start": 4236,
"cds_end": null,
"cds_length": 5382,
"cdna_start": 4477,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4131C>A",
"hgvs_p": "p.Thr1377Thr",
"transcript": "XM_017016422.2",
"protein_id": "XP_016871911.1",
"transcript_support_level": null,
"aa_start": 1377,
"aa_end": null,
"aa_length": 1758,
"cds_start": 4131,
"cds_end": null,
"cds_length": 5277,
"cdna_start": 4372,
"cdna_end": null,
"cdna_length": 7037,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIAA1217",
"gene_hgnc_id": 25428,
"hgvs_c": "c.4128C>A",
"hgvs_p": "p.Thr1376Thr",
"transcript": "XM_047425501.1",
"protein_id": "XP_047281457.1",
"transcript_support_level": null,
"aa_start": 1376,
"aa_end": null,
"aa_length": 1757,
"cds_start": 4128,
"cds_end": null,
"cds_length": 5274,
"cdna_start": 4369,
"cdna_end": null,
"cdna_length": 7034,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
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