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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-26780561-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=26780561&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 26780561,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000376140.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "NM_001012750.3",
"protein_id": "NP_001012768.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 481,
"cds_start": -4,
"cds_end": null,
"cds_length": 1446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3515,
"mane_select": "ENST00000376140.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000376140.4",
"protein_id": "ENSP00000365310.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 481,
"cds_start": -4,
"cds_end": null,
"cds_length": 1446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3515,
"mane_select": "NM_001012750.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000376142.6",
"protein_id": "ENSP00000365312.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 508,
"cds_start": -4,
"cds_end": null,
"cds_length": 1527,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3576,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000359188.8",
"protein_id": "ENSP00000352114.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 480,
"cds_start": -4,
"cds_end": null,
"cds_length": 1443,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3492,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000376139.6",
"protein_id": "ENSP00000365309.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 476,
"cds_start": -4,
"cds_end": null,
"cds_length": 1431,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3516,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000376138.7",
"protein_id": "ENSP00000365308.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 452,
"cds_start": -4,
"cds_end": null,
"cds_length": 1359,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000376170.8",
"protein_id": "ENSP00000365340.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 451,
"cds_start": -4,
"cds_end": null,
"cds_length": 1356,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3362,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000376166.5",
"protein_id": "ENSP00000365336.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 446,
"cds_start": -4,
"cds_end": null,
"cds_length": 1341,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3441,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ABI1",
"gene_hgnc_id": 11320,
"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000376137.9",
"protein_id": "ENSP00000365307.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 422,
"cds_start": -4,
"cds_end": null,
"cds_length": 1269,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2136,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "ABI1",
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"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "ENST00000536334.5",
"protein_id": "ENSP00000439646.2",
"transcript_support_level": 1,
"aa_start": null,
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"aa_length": 393,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 2,
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"gene_symbol": "ABI1",
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"hgvs_c": "c.286-3320G>A",
"hgvs_p": null,
"transcript": "NM_005470.4",
"protein_id": "NP_005461.2",
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},
{
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"consequences": [
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],
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"gene_symbol": "ABI1",
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"transcript": "NM_001348029.2",
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},
{
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"consequences": [
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],
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"gene_symbol": "ABI1",
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"hgvs_c": "c.337-3320G>A",
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"transcript": "NM_001178116.2",
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},
{
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"strand": false,
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],
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"gene_symbol": "ABI1",
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},
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],
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},
{
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],
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"gene_symbol": "ABI1",
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},
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],
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"gene_symbol": "ABI1",
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"hgvs_c": "c.286-3320G>A",
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"transcript": "NM_001348033.2",
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},
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],
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"gene_symbol": "ABI1",
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"hgvs_c": "c.286-3320G>A",
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"transcript": "NM_001012752.3",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "ABI1",
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},
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],
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},
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],
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"gene_symbol": "ABI1",
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"hgvs_c": "c.286-3320G>A",
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"transcript": "NM_001178120.2",
"protein_id": "NP_001171591.1",
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},
{
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],
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"intron_rank": 2,
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"gene_symbol": "ABI1",
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