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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-27060339-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=27060339&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 27060339,
"ref": "A",
"alt": "G",
"effect": "splice_region_variant,intron_variant",
"transcript": "NM_014915.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "NM_014915.3",
"protein_id": "NP_055730.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1710,
"cds_start": null,
"cds_end": null,
"cds_length": 5133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000376087.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014915.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "ENST00000376087.5",
"protein_id": "ENSP00000365255.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1710,
"cds_start": null,
"cds_end": null,
"cds_length": 5133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_014915.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000376087.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "ENST00000436985.7",
"protein_id": "ENSP00000405112.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1709,
"cds_start": null,
"cds_end": null,
"cds_length": 5130,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000436985.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "ENST00000968143.1",
"protein_id": "ENSP00000638202.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2072,
"cds_start": null,
"cds_end": null,
"cds_length": 6219,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968143.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "ENST00000968140.1",
"protein_id": "ENSP00000638199.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2071,
"cds_start": null,
"cds_end": null,
"cds_length": 6216,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968140.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "NM_001256053.2",
"protein_id": "NP_001242982.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1709,
"cds_start": null,
"cds_end": null,
"cds_length": 5130,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256053.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1561+6T>C",
"hgvs_p": null,
"transcript": "ENST00000968141.1",
"protein_id": "ENSP00000638200.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1708,
"cds_start": null,
"cds_end": null,
"cds_length": 5127,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968141.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1465+6T>C",
"hgvs_p": null,
"transcript": "ENST00000968139.1",
"protein_id": "ENSP00000638198.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1676,
"cds_start": null,
"cds_end": null,
"cds_length": 5031,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968139.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1363+3649T>C",
"hgvs_p": null,
"transcript": "ENST00000968142.1",
"protein_id": "ENSP00000638201.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1642,
"cds_start": null,
"cds_end": null,
"cds_length": 4929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968142.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "ENST00000921906.1",
"protein_id": "ENSP00000591965.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1566,
"cds_start": null,
"cds_end": null,
"cds_length": 4701,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921906.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_017015928.2",
"protein_id": "XP_016871417.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2112,
"cds_start": null,
"cds_end": null,
"cds_length": 6339,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015928.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_047424821.1",
"protein_id": "XP_047280777.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2112,
"cds_start": null,
"cds_end": null,
"cds_length": 6339,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047424821.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_047424822.1",
"protein_id": "XP_047280778.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2112,
"cds_start": null,
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"cds_length": 6339,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047424822.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1552+6T>C",
"hgvs_p": null,
"transcript": "XM_017015929.2",
"protein_id": "XP_016871418.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2108,
"cds_start": null,
"cds_end": null,
"cds_length": 6327,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015929.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_006717423.3",
"protein_id": "XP_006717486.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2072,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006717423.3"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_047424824.1",
"protein_id": "XP_047280780.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2071,
"cds_start": null,
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"cds_length": 6216,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047424824.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_011519416.3",
"protein_id": "XP_011517718.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2062,
"cds_start": null,
"cds_end": null,
"cds_length": 6189,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011519416.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_047424825.1",
"protein_id": "XP_047280781.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "XM_047424825.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_006717425.5",
"protein_id": "XP_006717488.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cds_length": 6096,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006717425.5"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_017015932.2",
"protein_id": "XP_016871421.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015932.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1564+6T>C",
"hgvs_p": null,
"transcript": "XM_047424826.1",
"protein_id": "XP_047280782.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1975,
"cds_start": null,
"cds_end": null,
"cds_length": 5928,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047424826.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "ANKRD26",
"gene_hgnc_id": 29186,
"hgvs_c": "c.1465+6T>C",
"hgvs_p": null,
"transcript": "XM_047424827.1",
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"phenotype_combined": "not specified|Thrombocytopenia 2|not provided",
"pathogenicity_classification_combined": "Benign",
"custom_annotations": null
}
],
"message": null
}