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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-27936859-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=27936859&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 27936859,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_018076.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "NM_018076.5",
"protein_id": "NP_060546.2",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000305242.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018076.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "ENST00000305242.10",
"protein_id": "ENSP00000306410.5",
"transcript_support_level": 1,
"aa_start": 707,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_018076.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000305242.10"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "NM_001290020.2",
"protein_id": "NP_001276949.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001290020.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "ENST00000673439.1",
"protein_id": "ENSP00000500782.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000673439.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "ENST00000852623.1",
"protein_id": "ENSP00000522682.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852623.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "ENST00000923084.1",
"protein_id": "ENSP00000593143.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923084.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2002C>G",
"hgvs_p": "p.Arg668Gly",
"transcript": "ENST00000852625.1",
"protein_id": "ENSP00000522684.1",
"transcript_support_level": null,
"aa_start": 668,
"aa_end": null,
"aa_length": 1005,
"cds_start": 2002,
"cds_end": null,
"cds_length": 3018,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852625.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.1909C>G",
"hgvs_p": "p.Arg637Gly",
"transcript": "ENST00000923083.1",
"protein_id": "ENSP00000593142.1",
"transcript_support_level": null,
"aa_start": 637,
"aa_end": null,
"aa_length": 974,
"cds_start": 1909,
"cds_end": null,
"cds_length": 2925,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923083.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.1909C>G",
"hgvs_p": "p.Arg637Gly",
"transcript": "ENST00000923088.1",
"protein_id": "ENSP00000593147.1",
"transcript_support_level": null,
"aa_start": 637,
"aa_end": null,
"aa_length": 974,
"cds_start": 1909,
"cds_end": null,
"cds_length": 2925,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923088.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.1762C>G",
"hgvs_p": "p.Arg588Gly",
"transcript": "ENST00000923087.1",
"protein_id": "ENSP00000593146.1",
"transcript_support_level": null,
"aa_start": 588,
"aa_end": null,
"aa_length": 925,
"cds_start": 1762,
"cds_end": null,
"cds_length": 2778,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923087.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.1456C>G",
"hgvs_p": "p.Arg486Gly",
"transcript": "ENST00000923086.1",
"protein_id": "ENSP00000593145.1",
"transcript_support_level": null,
"aa_start": 486,
"aa_end": null,
"aa_length": 823,
"cds_start": 1456,
"cds_end": null,
"cds_length": 2472,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923086.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.1768C>G",
"hgvs_p": "p.Arg590Gly",
"transcript": "ENST00000852624.1",
"protein_id": "ENSP00000522683.1",
"transcript_support_level": null,
"aa_start": 590,
"aa_end": null,
"aa_length": 790,
"cds_start": 1768,
"cds_end": null,
"cds_length": 2373,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852624.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.1195C>G",
"hgvs_p": "p.Arg399Gly",
"transcript": "NM_001312689.2",
"protein_id": "NP_001299618.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 736,
"cds_start": 1195,
"cds_end": null,
"cds_length": 2211,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001312689.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.1195C>G",
"hgvs_p": "p.Arg399Gly",
"transcript": "ENST00000672841.1",
"protein_id": "ENSP00000499983.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 736,
"cds_start": 1195,
"cds_end": null,
"cds_length": 2211,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000672841.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.694C>G",
"hgvs_p": "p.Arg232Gly",
"transcript": "NM_001290021.2",
"protein_id": "NP_001276950.1",
"transcript_support_level": null,
"aa_start": 232,
"aa_end": null,
"aa_length": 612,
"cds_start": 694,
"cds_end": null,
"cds_length": 1839,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001290021.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.694C>G",
"hgvs_p": "p.Arg232Gly",
"transcript": "ENST00000672877.1",
"protein_id": "ENSP00000500120.1",
"transcript_support_level": null,
"aa_start": 232,
"aa_end": null,
"aa_length": 612,
"cds_start": 694,
"cds_end": null,
"cds_length": 1839,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000672877.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "XM_024448049.2",
"protein_id": "XP_024303817.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1107,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3324,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448049.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "XM_024448050.2",
"protein_id": "XP_024303818.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1107,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3324,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448050.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "XM_024448051.2",
"protein_id": "XP_024303819.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1107,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3324,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448051.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "XM_024448052.2",
"protein_id": "XP_024303820.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1107,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3324,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448052.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "XM_024448053.2",
"protein_id": "XP_024303821.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1087,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3264,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448053.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ODAD2",
"gene_hgnc_id": 25583,
"hgvs_c": "c.2119C>G",
"hgvs_p": "p.Arg707Gly",
"transcript": "XM_011519527.2",
"protein_id": "XP_011517829.1",
"transcript_support_level": null,
"aa_start": 707,
"aa_end": null,
"aa_length": 1064,
"cds_start": 2119,
"cds_end": null,
"cds_length": 3195,
"cdna_start": null,
"cdna_end": null,
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