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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-32910360-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=32910360&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 32910360,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000302278.8",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "NM_002211.4",
"protein_id": "NP_002202.2",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 798,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2397,
"cdna_start": 2113,
"cdna_end": null,
"cdna_length": 3735,
"mane_select": "ENST00000302278.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000302278.8",
"protein_id": "ENSP00000303351.3",
"transcript_support_level": 1,
"aa_start": 676,
"aa_end": null,
"aa_length": 798,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2397,
"cdna_start": 2113,
"cdna_end": null,
"cdna_length": 3735,
"mane_select": "NM_002211.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.1856G>C",
"hgvs_p": "p.Arg619Pro",
"transcript": "ENST00000488427.2",
"protein_id": "ENSP00000417508.2",
"transcript_support_level": 1,
"aa_start": 619,
"aa_end": null,
"aa_length": 741,
"cds_start": 1856,
"cds_end": null,
"cds_length": 2226,
"cdna_start": 2100,
"cdna_end": null,
"cdna_length": 3707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000677310.2",
"protein_id": "ENSP00000504508.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 825,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2478,
"cdna_start": 2380,
"cdna_end": null,
"cdna_length": 7110,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000678766.1",
"protein_id": "ENSP00000503538.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 825,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2478,
"cdna_start": 2136,
"cdna_end": null,
"cdna_length": 3780,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000676659.1",
"protein_id": "ENSP00000502979.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 819,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 2155,
"cdna_end": null,
"cdna_length": 3779,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2051G>C",
"hgvs_p": "p.Arg684Pro",
"transcript": "ENST00000474568.6",
"protein_id": "ENSP00000420282.2",
"transcript_support_level": 5,
"aa_start": 684,
"aa_end": null,
"aa_length": 809,
"cds_start": 2051,
"cds_end": null,
"cds_length": 2430,
"cdna_start": 3065,
"cdna_end": null,
"cdna_length": 4021,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2051G>C",
"hgvs_p": "p.Arg684Pro",
"transcript": "ENST00000677363.1",
"protein_id": "ENSP00000504791.1",
"transcript_support_level": null,
"aa_start": 684,
"aa_end": null,
"aa_length": 809,
"cds_start": 2051,
"cds_end": null,
"cds_length": 2430,
"cdna_start": 3065,
"cdna_end": null,
"cdna_length": 4809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "NM_033668.2",
"protein_id": "NP_391988.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 801,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2406,
"cdna_start": 2027,
"cdna_end": null,
"cdna_length": 3730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000423113.6",
"protein_id": "ENSP00000388694.1",
"transcript_support_level": 5,
"aa_start": 676,
"aa_end": null,
"aa_length": 801,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2406,
"cdna_start": 2113,
"cdna_end": null,
"cdna_length": 3816,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2036G>C",
"hgvs_p": "p.Arg679Pro",
"transcript": "ENST00000488494.6",
"protein_id": "ENSP00000418725.2",
"transcript_support_level": 4,
"aa_start": 679,
"aa_end": null,
"aa_length": 801,
"cds_start": 2036,
"cds_end": null,
"cds_length": 2406,
"cdna_start": 2119,
"cdna_end": null,
"cdna_length": 3726,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "NM_133376.3",
"protein_id": "NP_596867.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 798,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2397,
"cdna_start": 2230,
"cdna_end": null,
"cdna_length": 3852,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000396033.6",
"protein_id": "ENSP00000379350.2",
"transcript_support_level": 5,
"aa_start": 676,
"aa_end": null,
"aa_length": 798,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2397,
"cdna_start": 2163,
"cdna_end": null,
"cdna_length": 3784,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000417122.7",
"protein_id": "ENSP00000404546.3",
"transcript_support_level": 4,
"aa_start": 676,
"aa_end": null,
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"cds_start": 2027,
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"cdna_start": 2375,
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"cdna_length": 3982,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000437302.6",
"protein_id": "ENSP00000398029.2",
"transcript_support_level": 5,
"aa_start": 676,
"aa_end": null,
"aa_length": 798,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2397,
"cdna_start": 2667,
"cdna_end": null,
"cdna_length": 4274,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000677999.1",
"protein_id": "ENSP00000503546.1",
"transcript_support_level": null,
"aa_start": 676,
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"cds_start": 2027,
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"cdna_start": 2311,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000678701.1",
"protein_id": "ENSP00000504205.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 798,
"cds_start": 2027,
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"cdna_start": 2483,
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"cdna_length": 4090,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000678943.1",
"protein_id": "ENSP00000503916.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 798,
"cds_start": 2027,
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"cdna_start": 2394,
"cdna_end": null,
"cdna_length": 4001,
"mane_select": null,
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"feature": null
},
{
"aa_ref": "R",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000678952.1",
"protein_id": "ENSP00000504444.1",
"transcript_support_level": null,
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"aa_end": null,
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"feature": null
},
{
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"aa_alt": "P",
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"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2015G>C",
"hgvs_p": "p.Arg672Pro",
"transcript": "ENST00000678591.1",
"protein_id": "ENSP00000502883.1",
"transcript_support_level": null,
"aa_start": 672,
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"cds_start": 2015,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000609742.3",
"protein_id": "ENSP00000503306.1",
"transcript_support_level": 6,
"aa_start": 676,
"aa_end": null,
"aa_length": 793,
"cds_start": 2027,
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"cds_length": 2382,
"cdna_start": 2136,
"cdna_end": null,
"cdna_length": 4170,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
"gene_hgnc_id": 6153,
"hgvs_c": "c.2027G>C",
"hgvs_p": "p.Arg676Pro",
"transcript": "ENST00000676460.1",
"protein_id": "ENSP00000504641.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 789,
"cds_start": 2027,
"cds_end": null,
"cds_length": 2370,
"cdna_start": 2136,
"cdna_end": null,
"cdna_length": 4489,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ITGB1",
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}
],
"message": null
}