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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-72408038-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=72408038&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 72408038,
      "ref": "C",
      "alt": "T",
      "effect": "splice_acceptor_variant,intron_variant",
      "transcript": "NM_001441218.1",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1072-1G>A",
          "hgvs_p": null,
          "transcript": "NM_001195518.2",
          "protein_id": "NP_001182447.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 476,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1431,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000361114.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001195518.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1072-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000361114.10",
          "protein_id": "ENSP00000354415.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 476,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1431,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001195518.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000361114.10"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1303-1G>A",
          "hgvs_p": null,
          "transcript": "NM_001441218.1",
          "protein_id": "NP_001428147.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 553,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1662,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001441218.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1303-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000964210.1",
          "protein_id": "ENSP00000634269.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 553,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1662,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000964210.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1240-1G>A",
          "hgvs_p": null,
          "transcript": "NM_001441219.1",
          "protein_id": "NP_001428148.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 532,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1599,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001441219.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1240-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000897977.1",
          "protein_id": "ENSP00000568036.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 532,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1599,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000897977.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 11,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1126-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000964205.1",
          "protein_id": "ENSP00000634264.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 494,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1485,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000964205.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1114-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000964208.1",
          "protein_id": "ENSP00000634267.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000964208.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1105-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000964209.1",
          "protein_id": "ENSP00000634268.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 487,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1464,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000964209.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 11,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1090-1G>A",
          "hgvs_p": null,
          "transcript": "NM_001363513.2",
          "protein_id": "NP_001350442.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 482,
          "cds_start": null,
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          "cds_length": 1449,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001363513.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 11,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1090-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000642044.1",
          "protein_id": "ENSP00000493232.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 482,
          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
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        {
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 13,
          "intron_rank": 10,
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          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1084-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000635239.1",
          "protein_id": "ENSP00000489563.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "aa_length": 480,
          "cds_start": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        },
        {
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          "consequences": [
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            "intron_variant"
          ],
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          "intron_rank": 11,
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          "gene_symbol": "MICU1",
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          "hgvs_c": "c.1084-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000964207.1",
          "protein_id": "ENSP00000634266.1",
          "transcript_support_level": null,
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          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000964207.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
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          "intron_rank": 10,
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          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1078-1G>A",
          "hgvs_p": null,
          "transcript": "NM_006077.4",
          "protein_id": "NP_006068.2",
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        {
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          "consequences": [
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            "intron_variant"
          ],
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          "intron_rank": 10,
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          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1072-1G>A",
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          "transcript": "NM_001441220.1",
          "protein_id": "NP_001428149.1",
          "transcript_support_level": null,
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          "cds_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "feature": "NM_001441220.1"
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        {
          "aa_ref": null,
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          "canonical": false,
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          "consequences": [
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            "intron_variant"
          ],
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          "exon_count": 13,
          "intron_rank": 10,
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          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1072-1G>A",
          "hgvs_p": null,
          "transcript": "NM_001441221.1",
          "protein_id": "NP_001428150.1",
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001441221.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 13,
          "intron_rank": 10,
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          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1072-1G>A",
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          "transcript": "NM_001441222.1",
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        },
        {
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          "exon_count": 13,
          "intron_rank": 10,
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          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1072-1G>A",
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          "transcript": "NM_001441223.1",
          "protein_id": "NP_001428152.1",
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        },
        {
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          "consequences": [
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            "intron_variant"
          ],
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          "exon_count": 13,
          "intron_rank": 10,
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          "gene_symbol": "MICU1",
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          "hgvs_c": "c.1072-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000897972.1",
          "protein_id": "ENSP00000568031.1",
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000897972.1"
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "MICU1",
          "gene_hgnc_id": 1530,
          "hgvs_c": "c.1072-1G>A",
          "hgvs_p": null,
          "transcript": "ENST00000897973.1",
          "protein_id": "ENSP00000568032.1",
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      "clinvar_classification": "Pathogenic",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "P:2",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Pathogenic",
      "custom_annotations": null
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  "message": null
}