← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-10031159-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=10031159&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 10031159,
      "ref": "C",
      "alt": "T",
      "effect": "synonymous_variant",
      "transcript": "ENST00000256190.13",
      "consequences": [
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "NM_030962.4",
          "protein_id": "NP_112224.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1849,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5550,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 7450,
          "mane_select": "ENST00000256190.13",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000256190.13",
          "protein_id": "ENSP00000256190.8",
          "transcript_support_level": 1,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1849,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5550,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 7450,
          "mane_select": "NM_030962.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000533770.6",
          "protein_id": "ENSP00000509247.1",
          "transcript_support_level": 1,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1152,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 3459,
          "cdna_start": 291,
          "cdna_end": null,
          "cdna_length": 4914,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.441G>A",
          "hgvs_p": null,
          "transcript": "ENST00000526353.2",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 7399,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "NM_001386339.1",
          "protein_id": "NP_001373268.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1881,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5646,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 7546,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000689128.1",
          "protein_id": "ENSP00000509587.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1881,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5646,
          "cdna_start": 350,
          "cdna_end": null,
          "cdna_length": 7279,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000675281.2",
          "protein_id": "ENSP00000502491.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1874,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5625,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 7347,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000676387.2",
          "protein_id": "ENSP00000502779.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1868,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5607,
          "cdna_start": 429,
          "cdna_end": null,
          "cdna_length": 7167,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.327G>A",
          "hgvs_p": "p.Lys109Lys",
          "transcript": "NM_001424318.1",
          "protein_id": "NP_001411247.1",
          "transcript_support_level": null,
          "aa_start": 109,
          "aa_end": null,
          "aa_length": 1861,
          "cds_start": 327,
          "cds_end": null,
          "cds_length": 5586,
          "cdna_start": 871,
          "cdna_end": null,
          "cdna_length": 7880,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.327G>A",
          "hgvs_p": "p.Lys109Lys",
          "transcript": "NM_001425070.1",
          "protein_id": "NP_001411999.1",
          "transcript_support_level": null,
          "aa_start": 109,
          "aa_end": null,
          "aa_length": 1861,
          "cds_start": 327,
          "cds_end": null,
          "cds_length": 5586,
          "cdna_start": 671,
          "cdna_end": null,
          "cdna_length": 7680,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000689940.1",
          "protein_id": "ENSP00000508452.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1847,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5544,
          "cdna_start": 449,
          "cdna_end": null,
          "cdna_length": 7452,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.153G>A",
          "hgvs_p": "p.Lys51Lys",
          "transcript": "ENST00000689258.1",
          "protein_id": "ENSP00000510475.1",
          "transcript_support_level": null,
          "aa_start": 51,
          "aa_end": null,
          "aa_length": 1828,
          "cds_start": 153,
          "cds_end": null,
          "cds_length": 5487,
          "cdna_start": 294,
          "cdna_end": null,
          "cdna_length": 6667,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.327G>A",
          "hgvs_p": "p.Lys109Lys",
          "transcript": "NM_001425069.1",
          "protein_id": "NP_001411998.1",
          "transcript_support_level": null,
          "aa_start": 109,
          "aa_end": null,
          "aa_length": 1814,
          "cds_start": 327,
          "cds_end": null,
          "cds_length": 5445,
          "cdna_start": 671,
          "cdna_end": null,
          "cdna_length": 7539,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "NM_001386342.1",
          "protein_id": "NP_001373271.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1806,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5421,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 7321,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000692716.1",
          "protein_id": "ENSP00000509545.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1806,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 5421,
          "cdna_start": 443,
          "cdna_end": null,
          "cdna_length": 9215,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.12G>A",
          "hgvs_p": "p.Lys4Lys",
          "transcript": "ENST00000688344.1",
          "protein_id": "ENSP00000509987.1",
          "transcript_support_level": null,
          "aa_start": 4,
          "aa_end": null,
          "aa_length": 1718,
          "cds_start": 12,
          "cds_end": null,
          "cds_length": 5157,
          "cdna_start": 12,
          "cdna_end": null,
          "cdna_length": 6763,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000688206.1",
          "protein_id": "ENSP00000510516.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 284,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 855,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 1250,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000686079.1",
          "protein_id": "ENSP00000509599.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 238,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 717,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 2380,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000687256.1",
          "protein_id": "ENSP00000508741.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 235,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 708,
          "cdna_start": 437,
          "cdna_end": null,
          "cdna_length": 1124,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000687300.1",
          "protein_id": "ENSP00000508415.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 221,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 666,
          "cdna_start": 440,
          "cdna_end": null,
          "cdna_length": 2215,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "ENST00000693212.1",
          "protein_id": "ENSP00000510716.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 219,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 660,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 1700,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "XM_047427657.1",
          "protein_id": "XP_047283613.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1554,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 4665,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 4925,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "XM_011520395.4",
          "protein_id": "XP_011518697.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1267,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 3804,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 4245,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "XM_011520396.4",
          "protein_id": "XP_011518698.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1159,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 3480,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 5964,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "XM_047427658.1",
          "protein_id": "XP_047283614.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1116,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 3351,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 5835,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys",
          "transcript": "XM_017018377.3",
          "protein_id": "XP_016873866.1",
          "transcript_support_level": null,
          "aa_start": 97,
          "aa_end": null,
          "aa_length": 1105,
          "cds_start": 291,
          "cds_end": null,
          "cds_length": 3318,
          "cdna_start": 441,
          "cdna_end": null,
          "cdna_length": 3534,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.238G>A",
          "hgvs_p": null,
          "transcript": "ENST00000527019.6",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 662,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.247G>A",
          "hgvs_p": null,
          "transcript": "ENST00000533661.2",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 894,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.291G>A",
          "hgvs_p": null,
          "transcript": "ENST00000676324.2",
          "protein_id": "ENSP00000502578.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 7085,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.622G>A",
          "hgvs_p": null,
          "transcript": "ENST00000685217.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3128,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.291G>A",
          "hgvs_p": null,
          "transcript": "ENST00000687210.1",
          "protein_id": "ENSP00000509480.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2448,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.441G>A",
          "hgvs_p": null,
          "transcript": "ENST00000688417.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3171,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.*70G>A",
          "hgvs_p": null,
          "transcript": "ENST00000688739.1",
          "protein_id": "ENSP00000510449.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 531,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.*226G>A",
          "hgvs_p": null,
          "transcript": "ENST00000690806.1",
          "protein_id": "ENSP00000509417.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 636,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.291G>A",
          "hgvs_p": null,
          "transcript": "ENST00000693022.1",
          "protein_id": "ENSP00000508914.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1575,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.291G>A",
          "hgvs_p": null,
          "transcript": "ENST00000693201.1",
          "protein_id": "ENSP00000510346.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 987,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.*70G>A",
          "hgvs_p": null,
          "transcript": "ENST00000688739.1",
          "protein_id": "ENSP00000510449.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 531,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SBF2",
          "gene_hgnc_id": 2135,
          "hgvs_c": "n.*226G>A",
          "hgvs_p": null,
          "transcript": "ENST00000690806.1",
          "protein_id": "ENSP00000509417.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 636,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "SBF2",
      "gene_hgnc_id": 2135,
      "dbsnp": "rs150056369",
      "frequency_reference_population": 0.00007375719,
      "hom_count_reference_population": 1,
      "allele_count_reference_population": 119,
      "gnomad_exomes_af": 0.0000438019,
      "gnomad_genomes_af": 0.000361182,
      "gnomad_exomes_ac": 64,
      "gnomad_genomes_ac": 55,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 1,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.4000000059604645,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.4,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.722,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -15,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Moderate,BP6_Very_Strong,BP7,BS1",
      "acmg_by_gene": [
        {
          "score": -15,
          "benign_score": 15,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BP6_Very_Strong",
            "BP7",
            "BS1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000256190.13",
          "gene_symbol": "SBF2",
          "hgnc_id": 2135,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.291G>A",
          "hgvs_p": "p.Lys97Lys"
        }
      ],
      "clinvar_disease": "Charcot-Marie-Tooth disease type 4,Inborn genetic diseases,not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "LB:3",
      "phenotype_combined": "Charcot-Marie-Tooth disease type 4|not provided|Inborn genetic diseases",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}