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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-112214593-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=112214593&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 112214593,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_031938.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1333-169T>C",
"hgvs_p": null,
"transcript": "NM_031938.7",
"protein_id": "NP_114144.5",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": null,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000357685.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_031938.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1333-169T>C",
"hgvs_p": null,
"transcript": "ENST00000357685.11",
"protein_id": "ENSP00000350314.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": null,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_031938.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000357685.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1231-169T>C",
"hgvs_p": null,
"transcript": "ENST00000438022.5",
"protein_id": "ENSP00000414843.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 545,
"cds_start": null,
"cds_end": null,
"cds_length": 1638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000438022.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1231-169T>C",
"hgvs_p": null,
"transcript": "ENST00000531169.5",
"protein_id": "ENSP00000437053.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 545,
"cds_start": null,
"cds_end": null,
"cds_length": 1638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000531169.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1114-169T>C",
"hgvs_p": null,
"transcript": "ENST00000361053.8",
"protein_id": "ENSP00000354338.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 506,
"cds_start": null,
"cds_end": null,
"cds_length": 1521,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361053.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1333-169T>C",
"hgvs_p": null,
"transcript": "ENST00000856015.1",
"protein_id": "ENSP00000526074.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": null,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856015.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1333-169T>C",
"hgvs_p": null,
"transcript": "ENST00000856016.1",
"protein_id": "ENSP00000526075.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": null,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856016.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1333-169T>C",
"hgvs_p": null,
"transcript": "ENST00000856020.1",
"protein_id": "ENSP00000526079.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": null,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856020.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1321-169T>C",
"hgvs_p": null,
"transcript": "ENST00000856023.1",
"protein_id": "ENSP00000526082.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 575,
"cds_start": null,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856023.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1321-169T>C",
"hgvs_p": null,
"transcript": "ENST00000958916.1",
"protein_id": "ENSP00000628975.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 575,
"cds_start": null,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958916.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1231-169T>C",
"hgvs_p": null,
"transcript": "NM_001037290.4",
"protein_id": "NP_001032367.3",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 545,
"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "NM_001037290.4"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 9,
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"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1231-169T>C",
"hgvs_p": null,
"transcript": "ENST00000958920.1",
"protein_id": "ENSP00000628979.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 545,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000958920.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 9,
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"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1231-169T>C",
"hgvs_p": null,
"transcript": "NM_001256397.3",
"protein_id": "NP_001243326.2",
"transcript_support_level": null,
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"aa_length": 539,
"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "NM_001256397.3"
},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "BCO2",
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"hgvs_c": "c.1231-169T>C",
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"transcript": "ENST00000526088.5",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1204-169T>C",
"hgvs_p": null,
"transcript": "ENST00000856021.1",
"protein_id": "ENSP00000526080.1",
"transcript_support_level": null,
"aa_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000856021.1"
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 8,
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"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1204-169T>C",
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"transcript": "ENST00000856022.1",
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"feature": "ENST00000856022.1"
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1204-169T>C",
"hgvs_p": null,
"transcript": "ENST00000958912.1",
"protein_id": "ENSP00000628971.1",
"transcript_support_level": null,
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"biotype": "protein_coding",
"feature": "ENST00000958912.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1195-169T>C",
"hgvs_p": null,
"transcript": "ENST00000958919.1",
"protein_id": "ENSP00000628978.1",
"transcript_support_level": null,
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"cds_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1165-169T>C",
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"transcript": "ENST00000856019.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank_end": null,
"gene_symbol": "BCO2",
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"hgvs_c": "c.1332+732T>C",
"hgvs_p": null,
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},
{
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"strand": true,
"consequences": [
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],
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"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1114-169T>C",
"hgvs_p": null,
"transcript": "NM_001256398.3",
"protein_id": "NP_001243327.2",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256398.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "BCO2",
"gene_hgnc_id": 18503,
"hgvs_c": "c.1018-169T>C",
"hgvs_p": null,
"transcript": "NM_001256400.3",
"protein_id": "NP_001243329.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 474,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256400.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
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