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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-120475651-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=120475651&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 120475651,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_015313.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 33,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3277+144G>A",
"hgvs_p": null,
"transcript": "NM_015313.3",
"protein_id": "NP_056128.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1544,
"cds_start": null,
"cds_end": null,
"cds_length": 4635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000397843.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015313.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 33,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3277+144G>A",
"hgvs_p": null,
"transcript": "ENST00000397843.7",
"protein_id": "ENSP00000380942.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1544,
"cds_start": null,
"cds_end": null,
"cds_length": 4635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015313.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000397843.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 33,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.2968+144G>A",
"hgvs_p": null,
"transcript": "ENST00000532993.5",
"protein_id": "ENSP00000432984.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1441,
"cds_start": null,
"cds_end": null,
"cds_length": 4326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000532993.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3220+144G>A",
"hgvs_p": null,
"transcript": "NM_001198665.2",
"protein_id": "NP_001185594.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1525,
"cds_start": null,
"cds_end": null,
"cds_length": 4578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198665.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3220+144G>A",
"hgvs_p": null,
"transcript": "ENST00000356641.7",
"protein_id": "ENSP00000349056.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1525,
"cds_start": null,
"cds_end": null,
"cds_length": 4578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000356641.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3205+144G>A",
"hgvs_p": null,
"transcript": "ENST00000884479.1",
"protein_id": "ENSP00000554538.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1520,
"cds_start": null,
"cds_end": null,
"cds_length": 4563,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884479.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 33,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3277+144G>A",
"hgvs_p": null,
"transcript": "ENST00000884477.1",
"protein_id": "ENSP00000554536.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1518,
"cds_start": null,
"cds_end": null,
"cds_length": 4557,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884477.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 31,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3187+144G>A",
"hgvs_p": null,
"transcript": "ENST00000884478.1",
"protein_id": "ENSP00000554537.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1514,
"cds_start": null,
"cds_end": null,
"cds_length": 4545,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884478.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3157+144G>A",
"hgvs_p": null,
"transcript": "ENST00000884476.1",
"protein_id": "ENSP00000554535.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1504,
"cds_start": null,
"cds_end": null,
"cds_length": 4515,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884476.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 31,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3145+144G>A",
"hgvs_p": null,
"transcript": "ENST00000884475.1",
"protein_id": "ENSP00000554534.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1500,
"cds_start": null,
"cds_end": null,
"cds_length": 4503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884475.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 31,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3100+144G>A",
"hgvs_p": null,
"transcript": "ENST00000884473.1",
"protein_id": "ENSP00000554532.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1485,
"cds_start": null,
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"cds_length": 4458,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884473.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3220+144G>A",
"hgvs_p": null,
"transcript": "ENST00000884474.1",
"protein_id": "ENSP00000554533.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1447,
"cds_start": null,
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"cds_length": 4344,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884474.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 33,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.2968+144G>A",
"hgvs_p": null,
"transcript": "NM_001301084.2",
"protein_id": "NP_001288013.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001301084.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3202+144G>A",
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"transcript": "XM_006718805.4",
"protein_id": "XP_006718868.1",
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"biotype": "protein_coding",
"feature": "XM_006718805.4"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3157+144G>A",
"hgvs_p": null,
"transcript": "XM_047426659.1",
"protein_id": "XP_047282615.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"biotype": "protein_coding",
"feature": "XM_047426659.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 39,
"intron_rank": 31,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3145+144G>A",
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"transcript": "XM_047426660.1",
"protein_id": "XP_047282616.1",
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047426660.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 31,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3100+144G>A",
"hgvs_p": null,
"transcript": "XM_017017420.2",
"protein_id": "XP_016872909.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_017017420.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 31,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3082+144G>A",
"hgvs_p": null,
"transcript": "XM_047426661.1",
"protein_id": "XP_047282617.1",
"transcript_support_level": null,
"aa_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 38,
"intron_rank": 30,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.3025+144G>A",
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"transcript": "XM_047426662.1",
"protein_id": "XP_047282618.1",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 41,
"intron_rank": 33,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.2968+144G>A",
"hgvs_p": null,
"transcript": "XM_011542720.3",
"protein_id": "XP_011541022.1",
"transcript_support_level": null,
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"biotype": "protein_coding",
"feature": "XM_011542720.3"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 41,
"intron_rank": 33,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.2968+144G>A",
"hgvs_p": null,
"transcript": "XM_017017421.2",
"protein_id": "XP_016872910.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1441,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017421.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 32,
"intron_rank_end": null,
"gene_symbol": "ARHGEF12",
"gene_hgnc_id": 14193,
"hgvs_c": "c.2968+144G>A",
"hgvs_p": null,
"transcript": "XM_047426663.1",
"protein_id": "XP_047282619.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047426663.1"
},
{
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"canonical": false,
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}