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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-22677466-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=22677466&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 22677466,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000454584.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_001143830.3",
"protein_id": "NP_001137302.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2236,
"mane_select": "ENST00000454584.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "ENST00000454584.7",
"protein_id": "ENSP00000401145.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2236,
"mane_select": "NM_001143830.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "ENST00000278187.7",
"protein_id": "ENSP00000278187.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2170,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_001391933.1",
"protein_id": "NP_001378862.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 331,
"cds_start": -4,
"cds_end": null,
"cds_length": 996,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2149,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_001391934.1",
"protein_id": "NP_001378863.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_001391935.1",
"protein_id": "NP_001378864.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2002,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_001391936.1",
"protein_id": "NP_001378865.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2095,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_001391937.1",
"protein_id": "NP_001378866.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1979,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_005256.5",
"protein_id": "NP_005247.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2023,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 2,
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"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_177553.4",
"protein_id": "NP_808221.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 313,
"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
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"gene_symbol": "GAS2",
"gene_hgnc_id": 4167,
"hgvs_c": "c.145+2452G>C",
"hgvs_p": null,
"transcript": "NM_001351224.3",
"protein_id": "NP_001338153.1",
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},
{
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],
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"gene_symbol": "GAS2",
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"transcript": "ENST00000532398.1",
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},
{
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],
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"hgvs_c": "c.145+2452G>C",
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"transcript": "ENST00000528582.5",
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},
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],
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"gene_symbol": "GAS2",
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"hgvs_c": "c.145+2452G>C",
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},
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],
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},
{
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],
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"gene_symbol": "GAS2",
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},
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"strand": true,
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],
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"gene_symbol": "GAS2",
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"hgvs_c": "n.190+2452G>C",
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"transcript": "ENST00000533092.1",
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},
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],
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"intron_rank": 2,
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"gene_symbol": "GAS2",
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],
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},
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],
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"gene_symbol": "GAS2",
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"transcript": "XM_047426744.1",
"protein_id": "XP_047282700.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 3,
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"gene_symbol": "GAS2",
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"hgvs_c": "c.145+2452G>C",
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},
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}
],
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}