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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-27700188-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=27700188&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 27700188,
      "ref": "G",
      "alt": "A",
      "effect": "5_prime_UTR_variant",
      "transcript": "ENST00000356660.9",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-46C>T",
          "hgvs_p": null,
          "transcript": "NM_001709.5",
          "protein_id": "NP_001700.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 247,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 744,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3985,
          "mane_select": "ENST00000356660.9",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-46C>T",
          "hgvs_p": null,
          "transcript": "ENST00000356660.9",
          "protein_id": "ENSP00000349084.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 247,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 744,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3985,
          "mane_select": "NM_001709.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-153C>T",
          "hgvs_p": null,
          "transcript": "ENST00000418212.5",
          "protein_id": "ENSP00000400502.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 247,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 744,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4125,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-28C>T",
          "hgvs_p": null,
          "transcript": "ENST00000533246.5",
          "protein_id": "ENSP00000432376.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 247,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 744,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4000,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-59+783C>T",
          "hgvs_p": null,
          "transcript": "ENST00000438929.5",
          "protein_id": "ENSP00000414303.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 329,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 990,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4059,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.3+21224C>T",
          "hgvs_p": null,
          "transcript": "ENST00000314915.6",
          "protein_id": "ENSP00000320002.6",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 255,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 768,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4340,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-22+20241C>T",
          "hgvs_p": null,
          "transcript": "ENST00000395978.7",
          "protein_id": "ENSP00000379302.3",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 247,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 744,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3988,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-22+20158C>T",
          "hgvs_p": null,
          "transcript": "ENST00000395981.7",
          "protein_id": "ENSP00000379305.3",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 247,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 744,
          "cdna_start": null,
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          "cdna_length": 4071,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 2,
          "intron_rank": 1,
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          "gene_symbol": "BDNF",
          "gene_hgnc_id": 1033,
          "hgvs_c": "c.-22+783C>T",
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          "transcript": "ENST00000395983.7",
          "protein_id": "ENSP00000379307.3",
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        },
        {
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          "consequences": [
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          "intron_rank": 1,
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          "gene_symbol": "BDNF",
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          "hgvs_c": "c.-22+20456C>T",
          "hgvs_p": null,
          "transcript": "ENST00000525950.5",
          "protein_id": "ENSP00000432035.1",
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        {
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          "hgvs_c": "c.-22+488C>T",
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          "gene_symbol": "ENSG00000255496",
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          "hgvs_c": "n.-59+783C>T",
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          "transcript": "ENST00000530786.5",
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          "gene_symbol": "BDNF",
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          "transcript": "NM_001143805.1",
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        {
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          "hgvs_c": "c.-22+20158C>T",
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          "transcript": "NM_170732.4",
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        },
        {
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          ],
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          "gene_symbol": "BDNF",
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          "hgvs_c": "c.-22+1109C>T",
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          "transcript": "NM_170733.4",
          "protein_id": "NP_733929.1",
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          "cdna_length": 4018,
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          "feature": null
        }
      ],
      "gene_symbol": "BDNF",
      "gene_hgnc_id": 1033,
      "dbsnp": "rs56164415",
      "frequency_reference_population": 0.06251839,
      "hom_count_reference_population": 2438,
      "allele_count_reference_population": 61620,
      "gnomad_exomes_af": 0.0627833,
      "gnomad_genomes_af": 0.0610676,
      "gnomad_exomes_ac": 52326,
      "gnomad_genomes_ac": 9294,
      "gnomad_exomes_homalt": 2038,
      "gnomad_genomes_homalt": 400,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.05000000074505806,
      "computational_prediction_selected": "Uncertain_significance",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.05,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 2.486,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -8,
      "acmg_classification": "Benign",
      "acmg_criteria": "BA1",
      "acmg_by_gene": [
        {
          "score": -8,
          "benign_score": 8,
          "pathogenic_score": 0,
          "criteria": [
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000356660.9",
          "gene_symbol": "BDNF",
          "hgnc_id": 1033,
          "effects": [
            "5_prime_UTR_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.-46C>T",
          "hgvs_p": null
        },
        {
          "score": -8,
          "benign_score": 8,
          "pathogenic_score": 0,
          "criteria": [
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000530663.1",
          "gene_symbol": "ENSG00000255496",
          "hgnc_id": null,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.148-3666C>T",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "Variant of unknown significance",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Variant of unknown significance",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}