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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-46729509-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=46729509&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 46729509,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_000506.5",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1602G>C",
"hgvs_p": "p.Pro534Pro",
"transcript": "NM_000506.5",
"protein_id": "NP_000497.1",
"transcript_support_level": null,
"aa_start": 534,
"aa_end": null,
"aa_length": 622,
"cds_start": 1602,
"cds_end": null,
"cds_length": 1869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000311907.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000506.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1602G>C",
"hgvs_p": "p.Pro534Pro",
"transcript": "ENST00000311907.10",
"protein_id": "ENSP00000308541.5",
"transcript_support_level": 1,
"aa_start": 534,
"aa_end": null,
"aa_length": 622,
"cds_start": 1602,
"cds_end": null,
"cds_length": 1869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000506.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000311907.10"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1698G>C",
"hgvs_p": "p.Pro566Pro",
"transcript": "ENST00000862106.1",
"protein_id": "ENSP00000532165.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 654,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1965,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862106.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1650G>C",
"hgvs_p": "p.Pro550Pro",
"transcript": "ENST00000862118.1",
"protein_id": "ENSP00000532177.1",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 638,
"cds_start": 1650,
"cds_end": null,
"cds_length": 1917,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862118.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1647G>C",
"hgvs_p": "p.Pro549Pro",
"transcript": "ENST00000862102.1",
"protein_id": "ENSP00000532161.1",
"transcript_support_level": null,
"aa_start": 549,
"aa_end": null,
"aa_length": 637,
"cds_start": 1647,
"cds_end": null,
"cds_length": 1914,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862102.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1641G>C",
"hgvs_p": "p.Pro547Pro",
"transcript": "ENST00000862104.1",
"protein_id": "ENSP00000532163.1",
"transcript_support_level": null,
"aa_start": 547,
"aa_end": null,
"aa_length": 635,
"cds_start": 1641,
"cds_end": null,
"cds_length": 1908,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862104.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1629G>C",
"hgvs_p": "p.Pro543Pro",
"transcript": "ENST00000862111.1",
"protein_id": "ENSP00000532170.1",
"transcript_support_level": null,
"aa_start": 543,
"aa_end": null,
"aa_length": 631,
"cds_start": 1629,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862111.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1623G>C",
"hgvs_p": "p.Pro541Pro",
"transcript": "ENST00000862105.1",
"protein_id": "ENSP00000532164.1",
"transcript_support_level": null,
"aa_start": 541,
"aa_end": null,
"aa_length": 629,
"cds_start": 1623,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862105.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1599G>C",
"hgvs_p": "p.Pro533Pro",
"transcript": "ENST00000862096.1",
"protein_id": "ENSP00000532155.1",
"transcript_support_level": null,
"aa_start": 533,
"aa_end": null,
"aa_length": 621,
"cds_start": 1599,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862096.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1590G>C",
"hgvs_p": "p.Pro530Pro",
"transcript": "ENST00000862107.1",
"protein_id": "ENSP00000532166.1",
"transcript_support_level": null,
"aa_start": 530,
"aa_end": null,
"aa_length": 618,
"cds_start": 1590,
"cds_end": null,
"cds_length": 1857,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862107.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1584G>C",
"hgvs_p": "p.Pro528Pro",
"transcript": "ENST00000862112.1",
"protein_id": "ENSP00000532171.1",
"transcript_support_level": null,
"aa_start": 528,
"aa_end": null,
"aa_length": 616,
"cds_start": 1584,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862112.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1581G>C",
"hgvs_p": "p.Pro527Pro",
"transcript": "ENST00000862123.1",
"protein_id": "ENSP00000532182.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 615,
"cds_start": 1581,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862123.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1566G>C",
"hgvs_p": "p.Pro522Pro",
"transcript": "ENST00000862109.1",
"protein_id": "ENSP00000532168.1",
"transcript_support_level": null,
"aa_start": 522,
"aa_end": null,
"aa_length": 610,
"cds_start": 1566,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862109.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1560G>C",
"hgvs_p": "p.Pro520Pro",
"transcript": "ENST00000862103.1",
"protein_id": "ENSP00000532162.1",
"transcript_support_level": null,
"aa_start": 520,
"aa_end": null,
"aa_length": 608,
"cds_start": 1560,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862103.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1551G>C",
"hgvs_p": "p.Pro517Pro",
"transcript": "ENST00000862093.1",
"protein_id": "ENSP00000532152.1",
"transcript_support_level": null,
"aa_start": 517,
"aa_end": null,
"aa_length": 605,
"cds_start": 1551,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862093.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1551G>C",
"hgvs_p": "p.Pro517Pro",
"transcript": "ENST00000862117.1",
"protein_id": "ENSP00000532176.1",
"transcript_support_level": null,
"aa_start": 517,
"aa_end": null,
"aa_length": 605,
"cds_start": 1551,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862117.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1545G>C",
"hgvs_p": "p.Pro515Pro",
"transcript": "ENST00000862095.1",
"protein_id": "ENSP00000532154.1",
"transcript_support_level": null,
"aa_start": 515,
"aa_end": null,
"aa_length": 603,
"cds_start": 1545,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862095.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1539G>C",
"hgvs_p": "p.Pro513Pro",
"transcript": "ENST00000862114.1",
"protein_id": "ENSP00000532173.1",
"transcript_support_level": null,
"aa_start": 513,
"aa_end": null,
"aa_length": 601,
"cds_start": 1539,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862114.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1524G>C",
"hgvs_p": "p.Pro508Pro",
"transcript": "ENST00000862101.1",
"protein_id": "ENSP00000532160.1",
"transcript_support_level": null,
"aa_start": 508,
"aa_end": null,
"aa_length": 596,
"cds_start": 1524,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862101.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1512G>C",
"hgvs_p": "p.Pro504Pro",
"transcript": "ENST00000862098.1",
"protein_id": "ENSP00000532157.1",
"transcript_support_level": null,
"aa_start": 504,
"aa_end": null,
"aa_length": 592,
"cds_start": 1512,
"cds_end": null,
"cds_length": 1779,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862098.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1485G>C",
"hgvs_p": "p.Pro495Pro",
"transcript": "ENST00000530231.5",
"protein_id": "ENSP00000433907.1",
"transcript_support_level": 5,
"aa_start": 495,
"aa_end": null,
"aa_length": 583,
"cds_start": 1485,
"cds_end": null,
"cds_length": 1752,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000530231.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1473G>C",
"hgvs_p": "p.Pro491Pro",
"transcript": "ENST00000862094.1",
"protein_id": "ENSP00000532153.1",
"transcript_support_level": null,
"aa_start": 491,
"aa_end": null,
"aa_length": 579,
"cds_start": 1473,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862094.1"
},
{
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