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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-47166860-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=47166860&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 47166860,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001410995.1",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1232G>A",
"hgvs_p": "p.Ser411Asn",
"transcript": "NM_032389.6",
"protein_id": "NP_115765.2",
"transcript_support_level": null,
"aa_start": 411,
"aa_end": null,
"aa_length": 521,
"cds_start": 1232,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000524782.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032389.6"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1232G>A",
"hgvs_p": "p.Ser411Asn",
"transcript": "ENST00000524782.6",
"protein_id": "ENSP00000434442.1",
"transcript_support_level": 1,
"aa_start": 411,
"aa_end": null,
"aa_length": 521,
"cds_start": 1232,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032389.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000524782.6"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1349G>A",
"hgvs_p": "p.Ser450Asn",
"transcript": "ENST00000892878.1",
"protein_id": "ENSP00000562937.1",
"transcript_support_level": null,
"aa_start": 450,
"aa_end": null,
"aa_length": 560,
"cds_start": 1349,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892878.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1319G>A",
"hgvs_p": "p.Ser440Asn",
"transcript": "ENST00000946556.1",
"protein_id": "ENSP00000616615.1",
"transcript_support_level": null,
"aa_start": 440,
"aa_end": null,
"aa_length": 550,
"cds_start": 1319,
"cds_end": null,
"cds_length": 1653,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946556.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1316G>A",
"hgvs_p": "p.Ser439Asn",
"transcript": "ENST00000892879.1",
"protein_id": "ENSP00000562938.1",
"transcript_support_level": null,
"aa_start": 439,
"aa_end": null,
"aa_length": 549,
"cds_start": 1316,
"cds_end": null,
"cds_length": 1650,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892879.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1277G>A",
"hgvs_p": "p.Ser426Asn",
"transcript": "ENST00000892889.1",
"protein_id": "ENSP00000562948.1",
"transcript_support_level": null,
"aa_start": 426,
"aa_end": null,
"aa_length": 536,
"cds_start": 1277,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892889.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1274G>A",
"hgvs_p": "p.Ser425Asn",
"transcript": "NM_001410995.1",
"protein_id": "NP_001397924.1",
"transcript_support_level": null,
"aa_start": 425,
"aa_end": null,
"aa_length": 535,
"cds_start": 1274,
"cds_end": null,
"cds_length": 1608,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001410995.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1274G>A",
"hgvs_p": "p.Ser425Asn",
"transcript": "ENST00000525314.6",
"protein_id": "ENSP00000434809.2",
"transcript_support_level": 3,
"aa_start": 425,
"aa_end": null,
"aa_length": 535,
"cds_start": 1274,
"cds_end": null,
"cds_length": 1608,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525314.6"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1232G>A",
"hgvs_p": "p.Ser411Asn",
"transcript": "ENST00000924865.1",
"protein_id": "ENSP00000594924.1",
"transcript_support_level": null,
"aa_start": 411,
"aa_end": null,
"aa_length": 519,
"cds_start": 1232,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924865.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1220G>A",
"hgvs_p": "p.Ser407Asn",
"transcript": "ENST00000892884.1",
"protein_id": "ENSP00000562943.1",
"transcript_support_level": null,
"aa_start": 407,
"aa_end": null,
"aa_length": 517,
"cds_start": 1220,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892884.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1217G>A",
"hgvs_p": "p.Ser406Asn",
"transcript": "ENST00000892885.1",
"protein_id": "ENSP00000562944.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 516,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892885.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1217G>A",
"hgvs_p": "p.Ser406Asn",
"transcript": "ENST00000946554.1",
"protein_id": "ENSP00000616613.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 516,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946554.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1232G>A",
"hgvs_p": "p.Ser411Asn",
"transcript": "ENST00000924867.1",
"protein_id": "ENSP00000594926.1",
"transcript_support_level": null,
"aa_start": 411,
"aa_end": null,
"aa_length": 512,
"cds_start": 1232,
"cds_end": null,
"cds_length": 1539,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924867.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1190G>A",
"hgvs_p": "p.Ser397Asn",
"transcript": "ENST00000892881.1",
"protein_id": "ENSP00000562940.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 507,
"cds_start": 1190,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892881.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1190G>A",
"hgvs_p": "p.Ser397Asn",
"transcript": "ENST00000892883.1",
"protein_id": "ENSP00000562942.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 507,
"cds_start": 1190,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892883.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1175G>A",
"hgvs_p": "p.Ser392Asn",
"transcript": "ENST00000892882.1",
"protein_id": "ENSP00000562941.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 502,
"cds_start": 1175,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892882.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1148G>A",
"hgvs_p": "p.Ser383Asn",
"transcript": "NM_001242832.2",
"protein_id": "NP_001229761.1",
"transcript_support_level": null,
"aa_start": 383,
"aa_end": null,
"aa_length": 493,
"cds_start": 1148,
"cds_end": null,
"cds_length": 1482,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001242832.2"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1148G>A",
"hgvs_p": "p.Ser383Asn",
"transcript": "ENST00000426335.6",
"protein_id": "ENSP00000400226.3",
"transcript_support_level": 2,
"aa_start": 383,
"aa_end": null,
"aa_length": 493,
"cds_start": 1148,
"cds_end": null,
"cds_length": 1482,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000426335.6"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1145G>A",
"hgvs_p": "p.Ser382Asn",
"transcript": "ENST00000946550.1",
"protein_id": "ENSP00000616609.1",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 492,
"cds_start": 1145,
"cds_end": null,
"cds_length": 1479,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946550.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1127G>A",
"hgvs_p": "p.Ser376Asn",
"transcript": "ENST00000946552.1",
"protein_id": "ENSP00000616611.1",
"transcript_support_level": null,
"aa_start": 376,
"aa_end": null,
"aa_length": 486,
"cds_start": 1127,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946552.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1103G>A",
"hgvs_p": "p.Ser368Asn",
"transcript": "ENST00000892887.1",
"protein_id": "ENSP00000562946.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 478,
"cds_start": 1103,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892887.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1100G>A",
"hgvs_p": "p.Ser367Asn",
"transcript": "ENST00000892886.1",
"protein_id": "ENSP00000562945.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 477,
"cds_start": 1100,
"cds_end": null,
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