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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-62881135-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=62881135&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 62881135,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000338663.12",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "NM_001013251.3",
"protein_id": "NP_001013269.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 529,
"cds_start": 112,
"cds_end": null,
"cds_length": 1590,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 1885,
"mane_select": "ENST00000338663.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "ENST00000338663.12",
"protein_id": "ENSP00000340815.7",
"transcript_support_level": 1,
"aa_start": 38,
"aa_end": null,
"aa_length": 529,
"cds_start": 112,
"cds_end": null,
"cds_length": 1590,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 1885,
"mane_select": "NM_001013251.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.415G>A",
"hgvs_p": "p.Glu139Lys",
"transcript": "ENST00000377890.6",
"protein_id": "ENSP00000367122.2",
"transcript_support_level": 1,
"aa_start": 139,
"aa_end": null,
"aa_length": 630,
"cds_start": 415,
"cds_end": null,
"cds_length": 1893,
"cdna_start": 583,
"cdna_end": null,
"cdna_length": 2161,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.229G>A",
"hgvs_p": "p.Glu77Lys",
"transcript": "ENST00000377889.6",
"protein_id": "ENSP00000367121.2",
"transcript_support_level": 1,
"aa_start": 77,
"aa_end": null,
"aa_length": 568,
"cds_start": 229,
"cds_end": null,
"cds_length": 1707,
"cdna_start": 355,
"cdna_end": null,
"cdna_length": 1993,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.508G>A",
"hgvs_p": "p.Glu170Lys",
"transcript": "ENST00000538084.2",
"protein_id": "ENSP00000440001.2",
"transcript_support_level": 3,
"aa_start": 170,
"aa_end": null,
"aa_length": 661,
"cds_start": 508,
"cds_end": null,
"cds_length": 1986,
"cdna_start": 669,
"cdna_end": null,
"cdna_length": 2334,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.487G>A",
"hgvs_p": "p.Glu163Lys",
"transcript": "ENST00000681569.1",
"protein_id": "ENSP00000506498.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 654,
"cds_start": 487,
"cds_end": null,
"cds_length": 1965,
"cdna_start": 648,
"cdna_end": null,
"cdna_length": 2313,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.418G>A",
"hgvs_p": "p.Glu140Lys",
"transcript": "NM_001012662.3",
"protein_id": "NP_001012680.1",
"transcript_support_level": null,
"aa_start": 140,
"aa_end": null,
"aa_length": 631,
"cds_start": 418,
"cds_end": null,
"cds_length": 1896,
"cdna_start": 579,
"cdna_end": null,
"cdna_length": 2224,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.418G>A",
"hgvs_p": "p.Glu140Lys",
"transcript": "ENST00000377891.6",
"protein_id": "ENSP00000367123.2",
"transcript_support_level": 2,
"aa_start": 140,
"aa_end": null,
"aa_length": 631,
"cds_start": 418,
"cds_end": null,
"cds_length": 1896,
"cdna_start": 577,
"cdna_end": null,
"cdna_length": 2222,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.415G>A",
"hgvs_p": "p.Glu139Lys",
"transcript": "NM_002394.6",
"protein_id": "NP_002385.3",
"transcript_support_level": null,
"aa_start": 139,
"aa_end": null,
"aa_length": 630,
"cds_start": 415,
"cds_end": null,
"cds_length": 1893,
"cdna_start": 576,
"cdna_end": null,
"cdna_length": 2221,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.394G>A",
"hgvs_p": "p.Glu132Lys",
"transcript": "ENST00000681467.1",
"protein_id": "ENSP00000506217.1",
"transcript_support_level": null,
"aa_start": 132,
"aa_end": null,
"aa_length": 623,
"cds_start": 394,
"cds_end": null,
"cds_length": 1872,
"cdna_start": 562,
"cdna_end": null,
"cdna_length": 2227,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.373G>A",
"hgvs_p": "p.Glu125Lys",
"transcript": "ENST00000680725.1",
"protein_id": "ENSP00000505585.1",
"transcript_support_level": null,
"aa_start": 125,
"aa_end": null,
"aa_length": 616,
"cds_start": 373,
"cds_end": null,
"cds_length": 1851,
"cdna_start": 532,
"cdna_end": null,
"cdna_length": 2197,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Glu108Lys",
"transcript": "ENST00000680729.1",
"protein_id": "ENSP00000505639.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 603,
"cds_start": 322,
"cds_end": null,
"cds_length": 1812,
"cdna_start": 588,
"cdna_end": null,
"cdna_length": 2265,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Glu108Lys",
"transcript": "ENST00000535296.5",
"protein_id": "ENSP00000444236.1",
"transcript_support_level": 5,
"aa_start": 108,
"aa_end": null,
"aa_length": 599,
"cds_start": 322,
"cds_end": null,
"cds_length": 1800,
"cdna_start": 424,
"cdna_end": null,
"cdna_length": 2084,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.229G>A",
"hgvs_p": "p.Glu77Lys",
"transcript": "NM_001012664.3",
"protein_id": "NP_001012682.1",
"transcript_support_level": null,
"aa_start": 77,
"aa_end": null,
"aa_length": 568,
"cds_start": 229,
"cds_end": null,
"cds_length": 1707,
"cdna_start": 390,
"cdna_end": null,
"cdna_length": 2035,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "ENST00000681232.1",
"protein_id": "ENSP00000506460.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 533,
"cds_start": 112,
"cds_end": null,
"cds_length": 1602,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 1917,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "ENST00000544377.2",
"protein_id": "ENSP00000442135.2",
"transcript_support_level": 4,
"aa_start": 38,
"aa_end": null,
"aa_length": 529,
"cds_start": 112,
"cds_end": null,
"cds_length": 1590,
"cdna_start": 376,
"cdna_end": null,
"cdna_length": 2041,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "ENST00000680631.1",
"protein_id": "ENSP00000506006.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 529,
"cds_start": 112,
"cds_end": null,
"cds_length": 1590,
"cdna_start": 225,
"cdna_end": null,
"cdna_length": 1890,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "ENST00000681657.1",
"protein_id": "ENSP00000505110.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 529,
"cds_start": 112,
"cds_end": null,
"cds_length": 1590,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 1905,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "ENST00000680297.1",
"protein_id": "ENSP00000506230.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 415,
"cds_start": 112,
"cds_end": null,
"cds_length": 1248,
"cdna_start": 273,
"cdna_end": null,
"cdna_length": 1975,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Glu38Lys",
"transcript": "ENST00000539458.1",
"protein_id": "ENSP00000438032.1",
"transcript_support_level": 5,
"aa_start": 38,
"aa_end": null,
"aa_length": 144,
"cds_start": 112,
"cds_end": null,
"cds_length": 437,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 565,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "n.112G>A",
"hgvs_p": null,
"transcript": "ENST00000541425.6",
"protein_id": "ENSP00000445858.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2029,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "n.112G>A",
"hgvs_p": null,
"transcript": "ENST00000679908.1",
"protein_id": "ENSP00000506238.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2029,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC3A2",
"gene_hgnc_id": 11026,
"hgvs_c": "n.322G>A",
"hgvs_p": null,
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"protein_id": "ENSP00000506366.1",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}