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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-67400699-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=67400699&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 4,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "effects": [
            "synonymous_variant"
          ],
          "gene_symbol": "PPP1CA",
          "hgnc_id": 9281,
          "hgvs_c": "c.441C>T",
          "hgvs_p": "p.Phe147Phe",
          "inheritance_mode": "AD",
          "pathogenic_score": 2,
          "score": -2,
          "transcript": "NM_001008709.2",
          "verdict": "Likely_benign"
        },
        {
          "benign_score": 4,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "TBC1D10C",
          "hgnc_id": 24702,
          "hgvs_c": "c.-13+1690G>A",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": -2,
          "transcript": "ENST00000946007.1",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_score": -2,
      "allele_count_reference_population": 1,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.57,
      "chr": "11",
      "clinvar_classification": "not provided",
      "clinvar_disease": "not provided",
      "clinvar_review_status": "no classification provided",
      "clinvar_submissions_summary": "O:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.5699999928474426,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 330,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1421,
          "cdna_start": 484,
          "cds_end": null,
          "cds_length": 993,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_002708.4",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000376745.9",
          "protein_coding": true,
          "protein_id": "NP_002699.1",
          "strand": false,
          "transcript": "NM_002708.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 330,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1421,
          "cdna_start": 484,
          "cds_end": null,
          "cds_length": 993,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000376745.9",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_002708.4",
          "protein_coding": true,
          "protein_id": "ENSP00000365936.4",
          "strand": false,
          "transcript": "ENST00000376745.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 341,
          "aa_ref": "F",
          "aa_start": 147,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1389,
          "cdna_start": 452,
          "cds_end": null,
          "cds_length": 1026,
          "cds_start": 441,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000312989.11",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.441C>T",
          "hgvs_p": "p.Phe147Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000326031.7",
          "strand": false,
          "transcript": "ENST00000312989.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1483,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 6,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000526510.6",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "n.489C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000526510.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 341,
          "aa_ref": "F",
          "aa_start": 147,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1454,
          "cdna_start": 517,
          "cds_end": null,
          "cds_length": 1026,
          "cds_start": 441,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_001008709.2",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.441C>T",
          "hgvs_p": "p.Phe147Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001008709.1",
          "strand": false,
          "transcript": "NM_001008709.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 335,
          "aa_ref": "F",
          "aa_start": 141,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1677,
          "cdna_start": 758,
          "cds_end": null,
          "cds_length": 1008,
          "cds_start": 423,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 6,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000679175.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.423C>T",
          "hgvs_p": "p.Phe141Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000503926.1",
          "strand": false,
          "transcript": "ENST00000679175.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 330,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1414,
          "cdna_start": 475,
          "cds_end": null,
          "cds_length": 993,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000930816.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000600874.1",
          "strand": false,
          "transcript": "ENST00000930816.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 329,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1440,
          "cdna_start": 506,
          "cds_end": null,
          "cds_length": 990,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000930813.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000600872.1",
          "strand": false,
          "transcript": "ENST00000930813.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 311,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1364,
          "cdna_start": 484,
          "cds_end": null,
          "cds_length": 936,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000896901.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000566960.1",
          "strand": false,
          "transcript": "ENST00000896901.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 311,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1337,
          "cdna_start": 457,
          "cds_end": null,
          "cds_length": 936,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000896903.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000566962.1",
          "strand": false,
          "transcript": "ENST00000896903.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 295,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1228,
          "cdna_start": 414,
          "cds_end": null,
          "cds_length": 888,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 6,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000527663.6",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000431146.2",
          "strand": false,
          "transcript": "ENST00000527663.6",
          "transcript_support_level": 3
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 295,
          "aa_ref": "F",
          "aa_start": 101,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1340,
          "cdna_start": 401,
          "cds_end": null,
          "cds_length": 888,
          "cds_start": 303,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000896899.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.303C>T",
          "hgvs_p": "p.Phe101Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000566958.1",
          "strand": false,
          "transcript": "ENST00000896899.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 286,
          "aa_ref": "F",
          "aa_start": 92,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1289,
          "cdna_start": 352,
          "cds_end": null,
          "cds_length": 861,
          "cds_start": 276,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 6,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "NM_206873.2",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.276C>T",
          "hgvs_p": "p.Phe92Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_996756.1",
          "strand": false,
          "transcript": "NM_206873.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 286,
          "aa_ref": "F",
          "aa_start": 92,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1054,
          "cdna_start": 365,
          "cds_end": null,
          "cds_length": 861,
          "cds_start": 276,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 6,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000358239.8",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.276C>T",
          "hgvs_p": "p.Phe92Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000350974.4",
          "strand": false,
          "transcript": "ENST00000358239.8",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 285,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1290,
          "cdna_start": 484,
          "cds_end": null,
          "cds_length": 858,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 6,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000896900.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000566959.1",
          "strand": false,
          "transcript": "ENST00000896900.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 276,
          "aa_ref": "F",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1266,
          "cdna_start": 491,
          "cds_end": null,
          "cds_length": 831,
          "cds_start": 408,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000930814.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.408C>T",
          "hgvs_p": "p.Phe136Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000600873.1",
          "strand": false,
          "transcript": "ENST00000930814.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 267,
          "aa_ref": "F",
          "aa_start": 92,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1198,
          "cdna_start": 324,
          "cds_end": null,
          "cds_length": 804,
          "cds_start": 276,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 6,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000896904.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.276C>T",
          "hgvs_p": "p.Phe92Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000566963.1",
          "strand": false,
          "transcript": "ENST00000896904.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 241,
          "aa_ref": "F",
          "aa_start": 92,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1110,
          "cdna_start": 308,
          "cds_end": null,
          "cds_length": 726,
          "cds_start": 276,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 5,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000930818.1",
          "gene_hgnc_id": 9281,
          "gene_symbol": "PPP1CA",
          "hgvs_c": "c.276C>T",
          "hgvs_p": "p.Phe92Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000600877.1",
          "strand": false,
          "transcript": "ENST00000930818.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 446,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2246,
          "cdna_start": null,
          "cds_end": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.