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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-6955944-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=6955944&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 6955944,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000278319.10",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "NM_013250.4",
"protein_id": "NP_037382.2",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1552,
"cdna_end": null,
"cdna_length": 3655,
"mane_select": "ENST00000278319.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "ENST00000278319.10",
"protein_id": "ENSP00000278319.5",
"transcript_support_level": 1,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1552,
"cdna_end": null,
"cdna_length": 3655,
"mane_select": "NM_013250.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.805+162G>C",
"hgvs_p": null,
"transcript": "ENST00000529903.1",
"protein_id": "ENSP00000432306.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 304,
"cds_start": -4,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1396,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "NM_001354853.2",
"protein_id": "NP_001341782.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1595,
"cdna_end": null,
"cdna_length": 3698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "ENST00000414517.6",
"protein_id": "ENSP00000393202.2",
"transcript_support_level": 5,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1353,
"cdna_end": null,
"cdna_length": 3257,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.289G>C",
"hgvs_p": "p.Val97Leu",
"transcript": "NM_001354855.2",
"protein_id": "NP_001341784.1",
"transcript_support_level": null,
"aa_start": 97,
"aa_end": null,
"aa_length": 291,
"cds_start": 289,
"cds_end": null,
"cds_length": 876,
"cdna_start": 1419,
"cdna_end": null,
"cdna_length": 3522,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.289G>C",
"hgvs_p": "p.Val97Leu",
"transcript": "NM_001354856.2",
"protein_id": "NP_001341785.1",
"transcript_support_level": null,
"aa_start": 97,
"aa_end": null,
"aa_length": 291,
"cds_start": 289,
"cds_end": null,
"cds_length": 876,
"cdna_start": 1595,
"cdna_end": null,
"cdna_length": 3698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.289G>C",
"hgvs_p": "p.Val97Leu",
"transcript": "NM_001354857.2",
"protein_id": "NP_001341786.1",
"transcript_support_level": null,
"aa_start": 97,
"aa_end": null,
"aa_length": 291,
"cds_start": 289,
"cds_end": null,
"cds_length": 876,
"cdna_start": 1462,
"cdna_end": null,
"cdna_length": 3565,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.253G>C",
"hgvs_p": "p.Val85Leu",
"transcript": "NM_001354858.2",
"protein_id": "NP_001341787.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 279,
"cds_start": 253,
"cds_end": null,
"cds_length": 840,
"cdna_start": 1499,
"cdna_end": null,
"cdna_length": 3602,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.253G>C",
"hgvs_p": "p.Val85Leu",
"transcript": "NM_001354859.2",
"protein_id": "NP_001341788.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 279,
"cds_start": 253,
"cds_end": null,
"cds_length": 840,
"cdna_start": 1366,
"cdna_end": null,
"cdna_length": 3469,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.253G>C",
"hgvs_p": "p.Val85Leu",
"transcript": "NM_001354860.2",
"protein_id": "NP_001341789.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 279,
"cds_start": 253,
"cds_end": null,
"cds_length": 840,
"cdna_start": 1323,
"cdna_end": null,
"cdna_length": 3426,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "XM_047427566.1",
"protein_id": "XP_047283522.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1728,
"cdna_end": null,
"cdna_length": 3831,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "XM_047427567.1",
"protein_id": "XP_047283523.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 5838,
"cdna_end": null,
"cdna_length": 7941,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "XM_047427568.1",
"protein_id": "XP_047283524.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1410,
"cdna_end": null,
"cdna_length": 3513,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "XM_047427569.1",
"protein_id": "XP_047283525.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 6014,
"cdna_end": null,
"cdna_length": 8117,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.967G>C",
"hgvs_p": "p.Val323Leu",
"transcript": "XM_047427570.1",
"protein_id": "XP_047283526.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 517,
"cds_start": 967,
"cds_end": null,
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"cdna_start": 5662,
"cdna_end": null,
"cdna_length": 7765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "n.1441G>C",
"hgvs_p": null,
"transcript": "ENST00000527171.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1602,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "n.1286G>C",
"hgvs_p": null,
"transcript": "ENST00000529755.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1452,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.805+162G>C",
"hgvs_p": null,
"transcript": "NM_001354854.1",
"protein_id": "NP_001341783.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 304,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "c.805+162G>C",
"hgvs_p": null,
"transcript": "ENST00000610573.4",
"protein_id": "ENSP00000484674.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 304,
"cds_start": -4,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
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"cdna_length": 1503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "n.215+162G>C",
"hgvs_p": null,
"transcript": "ENST00000532533.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 577,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "n.*126+162G>C",
"hgvs_p": null,
"transcript": "ENST00000636097.1",
"protein_id": "ENSP00000490414.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2150,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZNF215",
"gene_hgnc_id": 13007,
"hgvs_c": "n.*87+162G>C",
"hgvs_p": null,
"transcript": "ENST00000636606.1",
"protein_id": "ENSP00000490359.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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}