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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-8128206-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=8128206&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 8128206,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000309737.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.522-1399A>G",
"hgvs_p": null,
"transcript": "NM_001206671.4",
"protein_id": "NP_001193600.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 369,
"cds_start": -4,
"cds_end": null,
"cds_length": 1110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5788,
"mane_select": "ENST00000309737.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.522-1399A>G",
"hgvs_p": null,
"transcript": "ENST00000309737.11",
"protein_id": "ENSP00000308820.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 369,
"cds_start": -4,
"cds_end": null,
"cds_length": 1110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5788,
"mane_select": "NM_001206671.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.522-1402A>G",
"hgvs_p": null,
"transcript": "ENST00000343202.8",
"protein_id": "ENSP00000344904.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 368,
"cds_start": -4,
"cds_end": null,
"cds_length": 1107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2929,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.427+10066A>G",
"hgvs_p": null,
"transcript": "ENST00000425599.6",
"protein_id": "ENSP00000395320.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 288,
"cds_start": -4,
"cds_end": null,
"cds_length": 867,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 867,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.125-17069A>G",
"hgvs_p": null,
"transcript": "ENST00000335425.7",
"protein_id": "ENSP00000333988.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5223,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "n.125-1402A>G",
"hgvs_p": null,
"transcript": "ENST00000526962.1",
"protein_id": "ENSP00000434787.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2023,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "n.267A>G",
"hgvs_p": null,
"transcript": "ENST00000699457.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4994,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.522-1402A>G",
"hgvs_p": null,
"transcript": "NM_024557.6",
"protein_id": "NP_078833.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 368,
"cds_start": -4,
"cds_end": null,
"cds_length": 1107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5785,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.375-1315A>G",
"hgvs_p": null,
"transcript": "NM_001346693.2",
"protein_id": "NP_001333622.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 348,
"cds_start": -4,
"cds_end": null,
"cds_length": 1047,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5921,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.522-1315A>G",
"hgvs_p": null,
"transcript": "ENST00000531450.1",
"protein_id": "ENSP00000431658.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 327,
"cds_start": -4,
"cds_end": null,
"cds_length": 985,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1017,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.375-1399A>G",
"hgvs_p": null,
"transcript": "NM_001346694.2",
"protein_id": "NP_001333623.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 5,
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"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.375-1402A>G",
"hgvs_p": null,
"transcript": "NM_001346692.2",
"protein_id": "NP_001333621.1",
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"cdna_start": null,
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.427+10066A>G",
"hgvs_p": null,
"transcript": "NM_001206672.4",
"protein_id": "NP_001193601.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 5,
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"gene_symbol": "RIC3",
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"hgvs_c": "c.38+13A>G",
"hgvs_p": null,
"transcript": "NM_001346690.2",
"protein_id": "NP_001333619.1",
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},
{
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],
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"gene_symbol": "RIC3",
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"hgvs_c": "c.125-17069A>G",
"hgvs_p": null,
"transcript": "NM_001135109.4",
"protein_id": "NP_001128581.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 4,
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"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.521+9172A>G",
"hgvs_p": null,
"transcript": "NM_001346691.2",
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},
{
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],
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"gene_symbol": "RIC3",
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"hgvs_c": "n.383-1402A>G",
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"transcript": "ENST00000524799.5",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 5,
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"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "n.*439-1399A>G",
"hgvs_p": null,
"transcript": "ENST00000528463.5",
"protein_id": "ENSP00000435244.1",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RIC3",
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"hgvs_c": "n.737+13A>G",
"hgvs_p": null,
"transcript": "ENST00000530060.5",
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},
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],
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"gene_symbol": "RIC3",
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},
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "RIC3",
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"hgvs_c": "n.607-1402A>G",
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},
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "n.161-1402A>G",
"hgvs_p": null,
"transcript": "NR_144497.2",
"protein_id": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RIC3",
"gene_hgnc_id": 30338,
"hgvs_c": "c.522-1315A>G",
"hgvs_p": null,
"transcript": "XM_006718317.5",
"protein_id": "XP_006718380.1",
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"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
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},
{
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"protein_coding": true,
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