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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-9033742-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=9033742&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 9033742,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000649792.2",
"consequences": [
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.2057G>A",
"hgvs_p": "p.Cys686Tyr",
"transcript": "NM_001367977.2",
"protein_id": "NP_001354906.1",
"transcript_support_level": null,
"aa_start": 686,
"aa_end": null,
"aa_length": 1028,
"cds_start": 2057,
"cds_end": null,
"cds_length": 3087,
"cdna_start": 2128,
"cdna_end": null,
"cdna_length": 4727,
"mane_select": "ENST00000649792.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.2057G>A",
"hgvs_p": "p.Cys686Tyr",
"transcript": "ENST00000649792.2",
"protein_id": "ENSP00000497523.1",
"transcript_support_level": null,
"aa_start": 686,
"aa_end": null,
"aa_length": 1028,
"cds_start": 2057,
"cds_end": null,
"cds_length": 3087,
"cdna_start": 2128,
"cdna_end": null,
"cdna_length": 4727,
"mane_select": "NM_001367977.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1592G>A",
"hgvs_p": "p.Cys531Tyr",
"transcript": "ENST00000450649.6",
"protein_id": "ENSP00000415187.2",
"transcript_support_level": 1,
"aa_start": 531,
"aa_end": null,
"aa_length": 807,
"cds_start": 1592,
"cds_end": null,
"cds_length": 2424,
"cdna_start": 1610,
"cdna_end": null,
"cdna_length": 2912,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1970G>A",
"hgvs_p": "p.Cys657Tyr",
"transcript": "NM_001330199.3",
"protein_id": "NP_001317128.1",
"transcript_support_level": null,
"aa_start": 657,
"aa_end": null,
"aa_length": 999,
"cds_start": 1970,
"cds_end": null,
"cds_length": 3000,
"cdna_start": 2041,
"cdna_end": null,
"cdna_length": 4640,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1970G>A",
"hgvs_p": "p.Cys657Tyr",
"transcript": "ENST00000309263.7",
"protein_id": "ENSP00000310658.3",
"transcript_support_level": 5,
"aa_start": 657,
"aa_end": null,
"aa_length": 999,
"cds_start": 1970,
"cds_end": null,
"cds_length": 3000,
"cdna_start": 2043,
"cdna_end": null,
"cdna_length": 3727,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1592G>A",
"hgvs_p": "p.Cys531Tyr",
"transcript": "NM_001170690.3",
"protein_id": "NP_001164161.1",
"transcript_support_level": null,
"aa_start": 531,
"aa_end": null,
"aa_length": 807,
"cds_start": 1592,
"cds_end": null,
"cds_length": 2424,
"cdna_start": 1663,
"cdna_end": null,
"cdna_length": 4064,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1934G>A",
"hgvs_p": "p.Cys645Tyr",
"transcript": "XM_005253034.5",
"protein_id": "XP_005253091.2",
"transcript_support_level": null,
"aa_start": 645,
"aa_end": null,
"aa_length": 987,
"cds_start": 1934,
"cds_end": null,
"cds_length": 2964,
"cdna_start": 2005,
"cdna_end": null,
"cdna_length": 4604,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.2057G>A",
"hgvs_p": "p.Cys686Tyr",
"transcript": "XM_011520246.3",
"protein_id": "XP_011518548.1",
"transcript_support_level": null,
"aa_start": 686,
"aa_end": null,
"aa_length": 962,
"cds_start": 2057,
"cds_end": null,
"cds_length": 2889,
"cdna_start": 2128,
"cdna_end": null,
"cdna_length": 4529,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1853G>A",
"hgvs_p": "p.Cys618Tyr",
"transcript": "XM_011520247.3",
"protein_id": "XP_011518549.1",
"transcript_support_level": null,
"aa_start": 618,
"aa_end": null,
"aa_length": 960,
"cds_start": 1853,
"cds_end": null,
"cds_length": 2883,
"cdna_start": 1924,
"cdna_end": null,
"cdna_length": 4523,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1847G>A",
"hgvs_p": "p.Cys616Tyr",
"transcript": "XM_017018080.2",
"protein_id": "XP_016873569.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 958,
"cds_start": 1847,
"cds_end": null,
"cds_length": 2877,
"cdna_start": 1918,
"cdna_end": null,
"cdna_length": 4517,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.2057G>A",
"hgvs_p": "p.Cys686Tyr",
"transcript": "XM_005253035.5",
"protein_id": "XP_005253092.2",
"transcript_support_level": null,
"aa_start": 686,
"aa_end": null,
"aa_length": 953,
"cds_start": 2057,
"cds_end": null,
"cds_length": 2862,
"cdna_start": 2128,
"cdna_end": null,
"cdna_length": 3155,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1970G>A",
"hgvs_p": "p.Cys657Tyr",
"transcript": "XM_047427354.1",
"protein_id": "XP_047283310.1",
"transcript_support_level": null,
"aa_start": 657,
"aa_end": null,
"aa_length": 933,
"cds_start": 1970,
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"cdna_start": 2041,
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"cdna_length": 4442,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1970G>A",
"hgvs_p": "p.Cys657Tyr",
"transcript": "XM_047427355.1",
"protein_id": "XP_047283311.1",
"transcript_support_level": null,
"aa_start": 657,
"aa_end": null,
"aa_length": 924,
"cds_start": 1970,
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"cdna_start": 2041,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
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"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1934G>A",
"hgvs_p": "p.Cys645Tyr",
"transcript": "XM_047427356.1",
"protein_id": "XP_047283312.1",
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"cdna_start": 2005,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1730G>A",
"hgvs_p": "p.Cys577Tyr",
"transcript": "XM_005253036.5",
"protein_id": "XP_005253093.2",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 919,
"cds_start": 1730,
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"cdna_start": 1801,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
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"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1934G>A",
"hgvs_p": "p.Cys645Tyr",
"transcript": "XM_047427358.1",
"protein_id": "XP_047283314.1",
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1853G>A",
"hgvs_p": "p.Cys618Tyr",
"transcript": "XM_047427361.1",
"protein_id": "XP_047283317.1",
"transcript_support_level": null,
"aa_start": 618,
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"cds_start": 1853,
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"cdna_start": 1924,
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"mane_select": null,
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"biotype": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1847G>A",
"hgvs_p": "p.Cys616Tyr",
"transcript": "XM_017018081.2",
"protein_id": "XP_016873570.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 892,
"cds_start": 1847,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
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"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.2057G>A",
"hgvs_p": "p.Cys686Tyr",
"transcript": "XM_047427362.1",
"protein_id": "XP_047283318.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
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"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1853G>A",
"hgvs_p": "p.Cys618Tyr",
"transcript": "XM_047427363.1",
"protein_id": "XP_047283319.1",
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},
{
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"strand": false,
"consequences": [
"missense_variant"
],
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"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1592G>A",
"hgvs_p": "p.Cys531Tyr",
"transcript": "XM_005253037.5",
"protein_id": "XP_005253094.2",
"transcript_support_level": null,
"aa_start": 531,
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"cds_start": 1592,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCUBE2",
"gene_hgnc_id": 30425,
"hgvs_c": "c.1730G>A",
"hgvs_p": "p.Cys577Tyr",
"transcript": "XM_047427365.1",
"protein_id": "XP_047283321.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 853,
"cds_start": 1730,
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"cdna_start": 1801,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "C",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
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