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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-9090011-A-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=9090011&ref=A&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 9090011,
      "ref": "A",
      "alt": "T",
      "effect": "intron_variant",
      "transcript": "ENST00000649792.2",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "NM_001367977.2",
          "protein_id": "NP_001354906.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1028,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3087,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4727,
          "mane_select": "ENST00000649792.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "ENST00000649792.2",
          "protein_id": "ENSP00000497523.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1028,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3087,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4727,
          "mane_select": "NM_001367977.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "ENST00000450649.6",
          "protein_id": "ENSP00000415187.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 807,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2424,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2912,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000286935",
          "gene_hgnc_id": null,
          "hgvs_c": "n.592A>T",
          "hgvs_p": null,
          "transcript": "ENST00000663085.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1037,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "NM_001330199.3",
          "protein_id": "NP_001317128.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 999,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3000,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4640,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "ENST00000309263.7",
          "protein_id": "ENSP00000310658.3",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 999,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3000,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3727,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "NM_020974.4",
          "protein_id": "NP_066025.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 971,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2916,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4556,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "ENST00000520467.5",
          "protein_id": "ENSP00000429969.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 971,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2916,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3148,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "NM_001170690.3",
          "protein_id": "NP_001164161.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 807,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2424,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4064,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "n.408-182T>A",
          "hgvs_p": null,
          "transcript": "ENST00000534295.1",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 569,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_005253034.5",
          "protein_id": "XP_005253091.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 987,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2964,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4604,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_011520246.3",
          "protein_id": "XP_011518548.1",
          "transcript_support_level": null,
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          "aa_length": 962,
          "cds_start": -4,
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          "cds_length": 2889,
          "cdna_start": null,
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          "cdna_length": 4529,
          "mane_select": null,
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          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_011520247.3",
          "protein_id": "XP_011518549.1",
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          "aa_length": 960,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 4523,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
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          "exon_count": 21,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_017018080.2",
          "protein_id": "XP_016873569.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 958,
          "cds_start": -4,
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          "cds_length": 2877,
          "cdna_start": null,
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          "cdna_length": 4517,
          "mane_select": null,
          "mane_plus": null,
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          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
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          "transcript": "XM_005253035.5",
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        {
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          "strand": false,
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          ],
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          "exon_count": 21,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_047427353.1",
          "protein_id": "XP_047283309.1",
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          "aa_length": 942,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 4469,
          "mane_select": null,
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          "biotype": null,
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        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 21,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_047427354.1",
          "protein_id": "XP_047283310.1",
          "transcript_support_level": null,
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          "mane_select": null,
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          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 21,
          "intron_rank": 1,
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          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
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          "transcript": "XM_047427355.1",
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        {
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          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_047427356.1",
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        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 20,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
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          "transcript": "XM_005253036.5",
          "protein_id": "XP_005253093.2",
          "transcript_support_level": null,
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          "cdna_start": null,
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          "cdna_length": 4400,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.134-182T>A",
          "hgvs_p": null,
          "transcript": "XM_047427358.1",
          "protein_id": "XP_047283314.1",
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