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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-121580866-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=121580866&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 121580866,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001439016.1",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "NM_032590.5",
"protein_id": "NP_115979.3",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1336,
"cds_start": 46,
"cds_end": null,
"cds_length": 4011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000377071.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032590.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "ENST00000377071.9",
"protein_id": "ENSP00000366271.3",
"transcript_support_level": 1,
"aa_start": 16,
"aa_end": null,
"aa_length": 1336,
"cds_start": 46,
"cds_end": null,
"cds_length": 4011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032590.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377071.9"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "ENST00000538046.6",
"protein_id": "ENSP00000474307.1",
"transcript_support_level": 1,
"aa_start": 16,
"aa_end": null,
"aa_length": 507,
"cds_start": 46,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000538046.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "n.46C>A",
"hgvs_p": null,
"transcript": "ENST00000543025.5",
"protein_id": "ENSP00000438138.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000543025.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "NM_001439016.1",
"protein_id": "NP_001425945.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1362,
"cds_start": 46,
"cds_end": null,
"cds_length": 4089,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439016.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "NM_001439017.1",
"protein_id": "NP_001425946.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1336,
"cds_start": 46,
"cds_end": null,
"cds_length": 4011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439017.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "NM_001439018.1",
"protein_id": "NP_001425947.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1334,
"cds_start": 46,
"cds_end": null,
"cds_length": 4005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439018.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "XM_011538867.4",
"protein_id": "XP_011537169.2",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1399,
"cds_start": 46,
"cds_end": null,
"cds_length": 4200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011538867.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "XM_047429681.1",
"protein_id": "XP_047285637.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1396,
"cds_start": 46,
"cds_end": null,
"cds_length": 4191,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429681.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "XM_047429685.1",
"protein_id": "XP_047285641.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1365,
"cds_start": 46,
"cds_end": null,
"cds_length": 4098,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429685.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "XM_047429686.1",
"protein_id": "XP_047285642.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1363,
"cds_start": 46,
"cds_end": null,
"cds_length": 4092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429686.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "XM_047429689.1",
"protein_id": "XP_047285645.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1360,
"cds_start": 46,
"cds_end": null,
"cds_length": 4083,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429689.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "XM_047429703.1",
"protein_id": "XP_047285659.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1298,
"cds_start": 46,
"cds_end": null,
"cds_length": 3897,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429703.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.46C>A",
"hgvs_p": "p.Arg16Arg",
"transcript": "XM_047429705.1",
"protein_id": "XP_047285661.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 1296,
"cds_start": 46,
"cds_end": null,
"cds_length": 3891,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429705.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.-306C>A",
"hgvs_p": null,
"transcript": "ENST00000611216.4",
"protein_id": "ENSP00000480847.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 559,
"cds_start": null,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000611216.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.63+158C>A",
"hgvs_p": null,
"transcript": "ENST00000717755.1",
"protein_id": "ENSP00000520643.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1341,
"cds_start": null,
"cds_end": null,
"cds_length": 4026,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000717755.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.63+158C>A",
"hgvs_p": null,
"transcript": "ENST00000717756.1",
"protein_id": "ENSP00000520644.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1341,
"cds_start": null,
"cds_end": null,
"cds_length": 4026,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000717756.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.63+158C>A",
"hgvs_p": null,
"transcript": "NM_001439022.1",
"protein_id": "NP_001425951.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1315,
"cds_start": null,
"cds_end": null,
"cds_length": 3948,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439022.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.63+158C>A",
"hgvs_p": null,
"transcript": "NM_001439023.1",
"protein_id": "NP_001425952.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1313,
"cds_start": null,
"cds_end": null,
"cds_length": 3942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439023.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.63+158C>A",
"hgvs_p": null,
"transcript": "NM_001439029.1",
"protein_id": "NP_001425958.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1277,
"cds_start": null,
"cds_end": null,
"cds_length": 3834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439029.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.63+158C>A",
"hgvs_p": null,
"transcript": "XM_047429682.1",
"protein_id": "XP_047285638.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1375,
"cds_start": null,
"cds_end": null,
"cds_length": 4128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429682.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM2B",
"gene_hgnc_id": 13610,
"hgvs_c": "c.63+158C>A",
"hgvs_p": null,
"transcript": "XM_047429691.1",
"protein_id": "XP_047285647.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1341,
"cds_start": null,
"cds_end": null,
"cds_length": 4026,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047429691.1"
},
{
"aa_ref": null,
"aa_alt": null,
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{
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],
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}
],
"message": null
}