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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-102673963-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=102673963&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 102673963,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000376052.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.3372-320G>A",
"hgvs_p": null,
"transcript": "NM_001330588.2",
"protein_id": "NP_001317517.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1262,
"cds_start": -4,
"cds_end": null,
"cds_length": 3789,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5484,
"mane_select": "ENST00000376052.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.3372-320G>A",
"hgvs_p": null,
"transcript": "ENST00000376052.5",
"protein_id": "ENSP00000365220.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1262,
"cds_start": -4,
"cds_end": null,
"cds_length": 3789,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5484,
"mane_select": "NM_001330588.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.3333-320G>A",
"hgvs_p": null,
"transcript": "ENST00000376065.8",
"protein_id": "ENSP00000365233.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1249,
"cds_start": -4,
"cds_end": null,
"cds_length": 3750,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3931,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "n.128G>A",
"hgvs_p": null,
"transcript": "ENST00000651823.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 781,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.3459-320G>A",
"hgvs_p": null,
"transcript": "NM_001367947.1",
"protein_id": "NP_001354876.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1291,
"cds_start": -4,
"cds_end": null,
"cds_length": 3876,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5571,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.3333-320G>A",
"hgvs_p": null,
"transcript": "NM_003291.4",
"protein_id": "NP_003282.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1249,
"cds_start": -4,
"cds_end": null,
"cds_length": 3750,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5445,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.3123-320G>A",
"hgvs_p": null,
"transcript": "ENST00000651544.1",
"protein_id": "ENSP00000498728.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1179,
"cds_start": -4,
"cds_end": null,
"cds_length": 3540,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4341,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.3105-320G>A",
"hgvs_p": null,
"transcript": "ENST00000652308.1",
"protein_id": "ENSP00000498955.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1173,
"cds_start": -4,
"cds_end": null,
"cds_length": 3522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3669,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.237-320G>A",
"hgvs_p": null,
"transcript": "ENST00000652033.1",
"protein_id": "ENSP00000498440.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 217,
"cds_start": -4,
"cds_end": null,
"cds_length": 654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1071,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "c.237-320G>A",
"hgvs_p": null,
"transcript": "ENST00000650757.1",
"protein_id": "ENSP00000499173.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 123,
"cds_start": -4,
"cds_end": null,
"cds_length": 374,
"cdna_start": null,
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"cdna_length": 632,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "n.447-320G>A",
"hgvs_p": null,
"transcript": "ENST00000466153.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 4,
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"gene_symbol": "TPP2",
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"hgvs_c": "n.592-320G>A",
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"transcript": "ENST00000482393.1",
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"aa_start": null,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "TPP2",
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"hgvs_c": "n.*4134-320G>A",
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"transcript": "ENST00000651448.1",
"protein_id": "ENSP00000499164.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 17,
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"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "n.*1411-320G>A",
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"transcript": "ENST00000651748.1",
"protein_id": "ENSP00000498868.1",
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},
{
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"strand": true,
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],
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"transcript": "ENST00000651921.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 28,
"intron_rank": 25,
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"gene_symbol": "TPP2",
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"hgvs_c": "n.4103-320G>A",
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"transcript": "ENST00000698381.1",
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},
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],
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 24,
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"gene_symbol": "TPP2",
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"hgvs_c": "n.3917-320G>A",
"hgvs_p": null,
"transcript": "ENST00000698383.1",
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},
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "TPP2",
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"hgvs_c": "n.*4145-320G>A",
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"transcript": "ENST00000698384.1",
"protein_id": "ENSP00000513690.1",
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},
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],
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},
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],
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},
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],
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"gene_symbol": "TPP2",
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"hgvs_c": "n.2696-320G>A",
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"transcript": "ENST00000698389.1",
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TPP2",
"gene_hgnc_id": 12016,
"hgvs_c": "n.2602-320G>A",
"hgvs_p": null,
"transcript": "ENST00000698390.1",
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},
{
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"strand": true,
"consequences": [
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],
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}