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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-50910116-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=50910116&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 50910116,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000336617.8",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "NM_024570.4",
"protein_id": "NP_078846.2",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 312,
"cds_start": 40,
"cds_end": null,
"cds_length": 939,
"cdna_start": 326,
"cdna_end": null,
"cdna_length": 1513,
"mane_select": "ENST00000336617.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000336617.8",
"protein_id": "ENSP00000337623.2",
"transcript_support_level": 1,
"aa_start": 14,
"aa_end": null,
"aa_length": 312,
"cds_start": 40,
"cds_end": null,
"cds_length": 939,
"cdna_start": 326,
"cdna_end": null,
"cdna_length": 1513,
"mane_select": "NM_024570.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000646960.1",
"protein_id": "ENSP00000496481.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 355,
"cds_start": 40,
"cds_end": null,
"cds_length": 1068,
"cdna_start": 336,
"cdna_end": null,
"cdna_length": 1711,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000642721.1",
"protein_id": "ENSP00000495650.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 319,
"cds_start": 40,
"cds_end": null,
"cds_length": 960,
"cdna_start": 113,
"cdna_end": null,
"cdna_length": 1033,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000713971.1",
"protein_id": "ENSP00000519263.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 319,
"cds_start": 40,
"cds_end": null,
"cds_length": 960,
"cdna_start": 72,
"cdna_end": null,
"cdna_length": 1278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000645188.1",
"protein_id": "ENSP00000496224.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 309,
"cds_start": 40,
"cds_end": null,
"cds_length": 930,
"cdna_start": 349,
"cdna_end": null,
"cdna_length": 1525,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000643682.1",
"protein_id": "ENSP00000493655.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 293,
"cds_start": 40,
"cds_end": null,
"cds_length": 882,
"cdna_start": 125,
"cdna_end": null,
"cdna_length": 1366,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000616907.2",
"protein_id": "ENSP00000482701.2",
"transcript_support_level": 3,
"aa_start": 14,
"aa_end": null,
"aa_length": 289,
"cds_start": 40,
"cds_end": null,
"cds_length": 870,
"cdna_start": 110,
"cdna_end": null,
"cdna_length": 3410,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000645955.1",
"protein_id": "ENSP00000495755.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 289,
"cds_start": 40,
"cds_end": null,
"cds_length": 870,
"cdna_start": 199,
"cdna_end": null,
"cdna_length": 1829,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000642995.1",
"protein_id": "ENSP00000493499.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 273,
"cds_start": 40,
"cds_end": null,
"cds_length": 822,
"cdna_start": 47,
"cdna_end": null,
"cdna_length": 922,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "NM_001411023.1",
"protein_id": "NP_001397952.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 266,
"cds_start": 40,
"cds_end": null,
"cds_length": 801,
"cdna_start": 326,
"cdna_end": null,
"cdna_length": 1583,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000645990.1",
"protein_id": "ENSP00000496571.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 266,
"cds_start": 40,
"cds_end": null,
"cds_length": 801,
"cdna_start": 64,
"cdna_end": null,
"cdna_length": 1323,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "NM_001142279.2",
"protein_id": "NP_001135751.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 257,
"cds_start": 40,
"cds_end": null,
"cds_length": 774,
"cdna_start": 439,
"cdna_end": null,
"cdna_length": 1669,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000422660.6",
"protein_id": "ENSP00000389877.1",
"transcript_support_level": 5,
"aa_start": 14,
"aa_end": null,
"aa_length": 257,
"cds_start": 40,
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"cdna_start": 370,
"cdna_end": null,
"cdna_length": 4885,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000646731.1",
"protein_id": "ENSP00000493828.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 254,
"cds_start": 40,
"cds_end": null,
"cds_length": 765,
"cdna_start": 349,
"cdna_end": null,
"cdna_length": 1567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000713969.1",
"protein_id": "ENSP00000519261.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 188,
"cds_start": 40,
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"cds_length": 567,
"cdna_start": 109,
"cdna_end": null,
"cdna_length": 665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "ENST00000644034.1",
"protein_id": "ENSP00000495456.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 128,
"cds_start": 40,
"cds_end": null,
"cds_length": 387,
"cdna_start": 204,
"cdna_end": null,
"cdna_length": 621,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "XM_047430613.1",
"protein_id": "XP_047286569.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 284,
"cds_start": 40,
"cds_end": null,
"cds_length": 855,
"cdna_start": 439,
"cdna_end": null,
"cdna_length": 1750,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "XM_011535230.3",
"protein_id": "XP_011533532.1",
"transcript_support_level": null,
"aa_start": 14,
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"aa_length": 261,
"cds_start": 40,
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"cdna_start": 439,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "XM_011535231.3",
"protein_id": "XP_011533533.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 259,
"cds_start": 40,
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"cdna_start": 439,
"cdna_end": null,
"cdna_length": 5054,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "c.40C>A",
"hgvs_p": "p.Arg14Arg",
"transcript": "XM_047430617.1",
"protein_id": "XP_047286573.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 258,
"cds_start": 40,
"cds_end": null,
"cds_length": 777,
"cdna_start": 439,
"cdna_end": null,
"cdna_length": 9082,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "n.40C>A",
"hgvs_p": null,
"transcript": "ENST00000643462.1",
"protein_id": "ENSP00000496130.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 491,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RNASEH2B",
"gene_hgnc_id": 25671,
"hgvs_c": "n.7C>A",
"hgvs_p": null,
"transcript": "ENST00000644183.1",
"protein_id": "ENSP00000495657.1",
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