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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-101876836-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=101876836&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 101876836,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000694906.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.460-5325C>T",
"hgvs_p": null,
"transcript": "NM_001352913.2",
"protein_id": "NP_001339842.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": -4,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4630,
"mane_select": "ENST00000694906.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.460-5325C>T",
"hgvs_p": null,
"transcript": "ENST00000694906.1",
"protein_id": "ENSP00000511581.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": -4,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4630,
"mane_select": "NM_001352913.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.295-5325C>T",
"hgvs_p": null,
"transcript": "ENST00000334743.9",
"protein_id": "ENSP00000333905.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 524,
"cds_start": -4,
"cds_end": null,
"cds_length": 1575,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4328,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.295-5325C>T",
"hgvs_p": null,
"transcript": "ENST00000350249.7",
"protein_id": "ENSP00000262239.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 485,
"cds_start": -4,
"cds_end": null,
"cds_length": 1458,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3845,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.295-5325C>T",
"hgvs_p": null,
"transcript": "ENST00000445439.7",
"protein_id": "ENSP00000408389.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 449,
"cds_start": -4,
"cds_end": null,
"cds_length": 1350,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1526,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.295-5325C>T",
"hgvs_p": null,
"transcript": "ENST00000557095.5",
"protein_id": "ENSP00000451179.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 384,
"cds_start": -4,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1307,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.388-5325C>T",
"hgvs_p": null,
"transcript": "NM_001161725.2",
"protein_id": "NP_001155197.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 555,
"cds_start": -4,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": 4558,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.388-5325C>T",
"hgvs_p": null,
"transcript": "ENST00000422945.6",
"protein_id": "ENSP00000412324.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 555,
"cds_start": -4,
"cds_end": null,
"cds_length": 1668,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4481,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.475-5325C>T",
"hgvs_p": null,
"transcript": "NM_001352914.2",
"protein_id": "NP_001339843.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 545,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "PPP2R5C",
"gene_hgnc_id": 9311,
"hgvs_c": "c.460-5325C>T",
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"transcript": "NM_001161726.2",
"protein_id": "NP_001155198.1",
"transcript_support_level": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 4,
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"gene_symbol": "PPP2R5C",
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"hgvs_c": "c.460-5325C>T",
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"transcript": "ENST00000328724.9",
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},
{
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],
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"gene_symbol": "PPP2R5C",
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},
{
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],
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"gene_symbol": "PPP2R5C",
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"transcript": "NM_001352912.1",
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},
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],
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},
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],
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"protein_id": "NP_001339844.1",
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},
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],
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],
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"transcript": "NM_001352916.2",
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},
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],
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"intron_rank": 2,
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"gene_symbol": "PPP2R5C",
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"hgvs_c": "c.295-5325C>T",
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"transcript": "ENST00000557621.5",
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],
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},
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],
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},
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],
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"gene_symbol": "PPP2R5C",
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"hgvs_c": "c.349-5325C>T",
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},
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],
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"intron_rank": 4,
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"gene_symbol": "PPP2R5C",
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"hgvs_c": "c.475-5325C>T",
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