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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-21250580-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=21250580&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 21250580,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000553300.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12731G>A",
"hgvs_p": null,
"transcript": "NM_004500.4",
"protein_id": "NP_004491.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 293,
"cds_start": -4,
"cds_end": null,
"cds_length": 882,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3165,
"mane_select": "ENST00000553300.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12731G>A",
"hgvs_p": null,
"transcript": "ENST00000553300.6",
"protein_id": "ENSP00000450544.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 293,
"cds_start": -4,
"cds_end": null,
"cds_length": 882,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3165,
"mane_select": "NM_004500.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12731G>A",
"hgvs_p": null,
"transcript": "ENST00000554455.5",
"protein_id": "ENSP00000451291.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 306,
"cds_start": -4,
"cds_end": null,
"cds_length": 921,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1784,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-36-16351G>A",
"hgvs_p": null,
"transcript": "ENST00000557201.5",
"protein_id": "ENSP00000452276.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 306,
"cds_start": -4,
"cds_end": null,
"cds_length": 921,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1371,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12021G>A",
"hgvs_p": null,
"transcript": "ENST00000430246.6",
"protein_id": "ENSP00000442816.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 293,
"cds_start": -4,
"cds_end": null,
"cds_length": 882,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4501,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12021G>A",
"hgvs_p": null,
"transcript": "ENST00000556897.5",
"protein_id": "ENSP00000451176.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 293,
"cds_start": -4,
"cds_end": null,
"cds_length": 882,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1252,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-36-16351G>A",
"hgvs_p": null,
"transcript": "ENST00000555883.5",
"protein_id": "ENSP00000450629.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 250,
"cds_start": -4,
"cds_end": null,
"cds_length": 753,
"cdna_start": null,
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"cdna_length": 1182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12731G>A",
"hgvs_p": null,
"transcript": "ENST00000556628.5",
"protein_id": "ENSP00000451652.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 226,
"cds_start": -4,
"cds_end": null,
"cds_length": 681,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1156,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-36-16351G>A",
"hgvs_p": null,
"transcript": "NM_001077442.2",
"protein_id": "NP_001070910.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 306,
"cds_start": -4,
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"cds_length": 921,
"cdna_start": null,
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"cdna_length": 3178,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
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"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12731G>A",
"hgvs_p": null,
"transcript": "NM_031314.3",
"protein_id": "NP_112604.2",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 4,
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"gene_symbol": "HNRNPC",
"gene_hgnc_id": 5035,
"hgvs_c": "c.-37+12021G>A",
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"transcript": "ENST00000420743.6",
"protein_id": "ENSP00000404848.2",
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},
{
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],
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},
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],
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"gene_symbol": "HNRNPC",
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"hgvs_c": "c.-36-16351G>A",
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"transcript": "NM_001077443.2",
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},
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],
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"gene_symbol": "HNRNPC",
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"hgvs_c": "c.-37+12731G>A",
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],
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"transcript": "ENST00000555914.5",
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},
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],
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},
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"gene_symbol": "HNRNPC",
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"transcript": "ENST00000554383.5",
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],
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"gene_symbol": "HNRNPC",
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"hgvs_c": "c.-35+12731G>A",
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},
{
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],
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"gene_symbol": "HNRNPC",
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"hgvs_c": "c.-125+12731G>A",
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"transcript": "ENST00000555137.5",
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