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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 14-58444071-CAA-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=58444071&ref=CAA&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "14",
      "pos": 58444071,
      "ref": "CAA",
      "alt": "C",
      "effect": "frameshift_variant",
      "transcript": "ENST00000652326.2",
      "consequences": [
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.704_705delAA",
          "hgvs_p": "p.Gln235fs",
          "transcript": "NM_001329943.3",
          "protein_id": "NP_001316872.1",
          "transcript_support_level": null,
          "aa_start": 235,
          "aa_end": null,
          "aa_length": 1548,
          "cds_start": 704,
          "cds_end": null,
          "cds_length": 4647,
          "cdna_start": 1250,
          "cdna_end": null,
          "cdna_length": 8558,
          "mane_select": "ENST00000652326.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.704_705delAA",
          "hgvs_p": "p.Gln235fs",
          "transcript": "ENST00000652326.2",
          "protein_id": "ENSP00000498929.1",
          "transcript_support_level": null,
          "aa_start": 235,
          "aa_end": null,
          "aa_length": 1548,
          "cds_start": 704,
          "cds_end": null,
          "cds_length": 4647,
          "cdna_start": 1250,
          "cdna_end": null,
          "cdna_length": 8558,
          "mane_select": "NM_001329943.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.659_660delAA",
          "hgvs_p": "p.Gln220fs",
          "transcript": "ENST00000619416.4",
          "protein_id": "ENSP00000478083.1",
          "transcript_support_level": 1,
          "aa_start": 220,
          "aa_end": null,
          "aa_length": 1533,
          "cds_start": 659,
          "cds_end": null,
          "cds_length": 4602,
          "cdna_start": 933,
          "cdna_end": null,
          "cdna_length": 8233,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.572_573delAA",
          "hgvs_p": "p.Gln191fs",
          "transcript": "ENST00000423743.7",
          "protein_id": "ENSP00000399427.3",
          "transcript_support_level": 1,
          "aa_start": 191,
          "aa_end": null,
          "aa_length": 1504,
          "cds_start": 572,
          "cds_end": null,
          "cds_length": 4515,
          "cdna_start": 830,
          "cdna_end": null,
          "cdna_length": 5339,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.704_705delAA",
          "hgvs_p": "p.Gln235fs",
          "transcript": "ENST00000261244.9",
          "protein_id": "ENSP00000261244.5",
          "transcript_support_level": 1,
          "aa_start": 235,
          "aa_end": null,
          "aa_length": 1472,
          "cds_start": 704,
          "cds_end": null,
          "cds_length": 4419,
          "cdna_start": 979,
          "cdna_end": null,
          "cdna_length": 4807,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.863_864delAA",
          "hgvs_p": "p.Gln288fs",
          "transcript": "NM_001244189.2",
          "protein_id": "NP_001231118.1",
          "transcript_support_level": null,
          "aa_start": 288,
          "aa_end": null,
          "aa_length": 1644,
          "cds_start": 863,
          "cds_end": null,
          "cds_length": 4935,
          "cdna_start": 1092,
          "cdna_end": null,
          "cdna_length": 8485,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.863_864delAA",
          "hgvs_p": "p.Gln288fs",
          "transcript": "ENST00000354386.10",
          "protein_id": "ENSP00000346359.6",
          "transcript_support_level": 2,
          "aa_start": 288,
          "aa_end": null,
          "aa_length": 1644,
          "cds_start": 863,
          "cds_end": null,
          "cds_length": 4935,
          "cdna_start": 1107,
          "cdna_end": null,
          "cdna_length": 5226,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.704_705delAA",
          "hgvs_p": "p.Gln235fs",
          "transcript": "NM_001329944.2",
          "protein_id": "NP_001316873.1",
          "transcript_support_level": null,
          "aa_start": 235,
          "aa_end": null,
          "aa_length": 1591,
          "cds_start": 704,
          "cds_end": null,
          "cds_length": 4776,
          "cdna_start": 1250,
          "cdna_end": null,
          "cdna_length": 8643,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "Q",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
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          "exon_count": 32,
          "intron_rank": null,
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          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.659_660delAA",
          "hgvs_p": "p.Gln220fs",
          "transcript": "NM_001244190.2",
          "protein_id": "NP_001231119.1",
          "transcript_support_level": null,
          "aa_start": 220,
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          "cds_start": 659,
          "cds_end": null,
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          "cdna_start": 935,
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          "mane_select": null,
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        {
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          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 6,
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          "exon_count": 30,
          "intron_rank": null,
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          "gene_symbol": "KIAA0586",
          "gene_hgnc_id": 19960,
          "hgvs_c": "c.704_705delAA",
          "hgvs_p": "p.Gln235fs",
          "transcript": "NM_001329946.2",
          "protein_id": "NP_001316875.1",
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          "cds_start": 704,
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        {
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          "hgvs_c": "c.704_705delAA",
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          "transcript": "ENST00000650904.1",
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          "cdna_start": 1276,
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        {
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          "intron_rank": null,
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          "gene_symbol": "KIAA0586",
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          "hgvs_c": "c.284_285delAA",
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          "transcript": "NM_001244193.2",
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      ],
      "gene_symbol": "KIAA0586",
      "gene_hgnc_id": 19960,
      "dbsnp": "rs770566897",
      "frequency_reference_population": 0.000024175162,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 39,
      "gnomad_exomes_af": 0.0000246391,
      "gnomad_genomes_af": 0.0000197197,
      "gnomad_exomes_ac": 36,
      "gnomad_genomes_ac": 3,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 1.459,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 18,
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PVS1,PM2,PP5_Very_Strong",
      "acmg_by_gene": [
        {
          "score": 18,
          "benign_score": 0,
          "pathogenic_score": 18,
          "criteria": [
            "PVS1",
            "PM2",
            "PP5_Very_Strong"
          ],
          "verdict": "Pathogenic",
          "transcript": "ENST00000652326.2",
          "gene_symbol": "KIAA0586",
          "hgnc_id": 19960,
          "effects": [
            "frameshift_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.704_705delAA",
          "hgvs_p": "p.Gln235fs"
        }
      ],
      "clinvar_disease": "Congenital cerebellar hypoplasia,Intellectual disability,Joubert syndrome 23,Neurodevelopmental disorder,Rod-cone dystrophy,Short-rib thoracic dysplasia 14 with polydactyly,not provided",
      "clinvar_classification": "Pathogenic",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "P:6",
      "phenotype_combined": "Joubert syndrome 23|Rod-cone dystrophy;Intellectual disability;Congenital cerebellar hypoplasia|not provided|Neurodevelopmental disorder|Joubert syndrome 23;Short-rib thoracic dysplasia 14 with polydactyly",
      "pathogenicity_classification_combined": "Pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}