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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-32168218-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=32168218&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 32168218,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000306901.9",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1269C>T",
"hgvs_p": "p.Gly423Gly",
"transcript": "NM_000746.6",
"protein_id": "NP_000737.1",
"transcript_support_level": null,
"aa_start": 423,
"aa_end": null,
"aa_length": 502,
"cds_start": 1269,
"cds_end": null,
"cds_length": 1509,
"cdna_start": 1349,
"cdna_end": null,
"cdna_length": 6149,
"mane_select": "ENST00000306901.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1269C>T",
"hgvs_p": "p.Gly423Gly",
"transcript": "ENST00000306901.9",
"protein_id": "ENSP00000303727.2",
"transcript_support_level": 1,
"aa_start": 423,
"aa_end": null,
"aa_length": 502,
"cds_start": 1269,
"cds_end": null,
"cds_length": 1509,
"cdna_start": 1349,
"cdna_end": null,
"cdna_length": 6149,
"mane_select": "NM_000746.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1356C>T",
"hgvs_p": "p.Gly452Gly",
"transcript": "NM_001190455.3",
"protein_id": "NP_001177384.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 531,
"cds_start": 1356,
"cds_end": null,
"cds_length": 1596,
"cdna_start": 1436,
"cdna_end": null,
"cdna_length": 6236,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1356C>T",
"hgvs_p": "p.Gly452Gly",
"transcript": "ENST00000454250.7",
"protein_id": "ENSP00000407546.3",
"transcript_support_level": 2,
"aa_start": 452,
"aa_end": null,
"aa_length": 531,
"cds_start": 1356,
"cds_end": null,
"cds_length": 1596,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 2093,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1356C>T",
"hgvs_p": "p.Gly452Gly",
"transcript": "ENST00000675428.1",
"protein_id": "ENSP00000502560.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 531,
"cds_start": 1356,
"cds_end": null,
"cds_length": 1596,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 2093,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1083C>T",
"hgvs_p": "p.Gly361Gly",
"transcript": "ENST00000636603.1",
"protein_id": "ENSP00000490513.1",
"transcript_support_level": 5,
"aa_start": 361,
"aa_end": null,
"aa_length": 440,
"cds_start": 1083,
"cds_end": null,
"cds_length": 1323,
"cdna_start": 1350,
"cdna_end": null,
"cdna_length": 2012,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1083C>T",
"hgvs_p": "p.Gly361Gly",
"transcript": "ENST00000637033.1",
"protein_id": "ENSP00000490227.1",
"transcript_support_level": 5,
"aa_start": 361,
"aa_end": null,
"aa_length": 440,
"cds_start": 1083,
"cds_end": null,
"cds_length": 1323,
"cdna_start": 1255,
"cdna_end": null,
"cdna_length": 3204,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1032C>T",
"hgvs_p": "p.Gly344Gly",
"transcript": "ENST00000637183.1",
"protein_id": "ENSP00000490365.1",
"transcript_support_level": 5,
"aa_start": 344,
"aa_end": null,
"aa_length": 423,
"cds_start": 1032,
"cds_end": null,
"cds_length": 1272,
"cdna_start": 1213,
"cdna_end": null,
"cdna_length": 2912,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1221C>T",
"hgvs_p": "p.Gly407Gly",
"transcript": "XM_011521176.4",
"protein_id": "XP_011519478.2",
"transcript_support_level": null,
"aa_start": 407,
"aa_end": null,
"aa_length": 486,
"cds_start": 1221,
"cds_end": null,
"cds_length": 1461,
"cdna_start": 1698,
"cdna_end": null,
"cdna_length": 6498,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1086C>T",
"hgvs_p": "p.Gly362Gly",
"transcript": "XM_047432126.1",
"protein_id": "XP_047288082.1",
"transcript_support_level": null,
"aa_start": 362,
"aa_end": null,
"aa_length": 441,
"cds_start": 1086,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1201,
"cdna_end": null,
"cdna_length": 6001,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.1083C>T",
"hgvs_p": "p.Gly361Gly",
"transcript": "XM_047432127.1",
"protein_id": "XP_047288083.1",
"transcript_support_level": null,
"aa_start": 361,
"aa_end": null,
"aa_length": 440,
"cds_start": 1083,
"cds_end": null,
"cds_length": 1323,
"cdna_start": 1198,
"cdna_end": null,
"cdna_length": 5998,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.966C>T",
"hgvs_p": "p.Gly322Gly",
"transcript": "XM_011521177.3",
"protein_id": "XP_011519479.1",
"transcript_support_level": null,
"aa_start": 322,
"aa_end": null,
"aa_length": 401,
"cds_start": 966,
"cds_end": null,
"cds_length": 1206,
"cdna_start": 1323,
"cdna_end": null,
"cdna_length": 6123,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.*770C>T",
"hgvs_p": null,
"transcript": "ENST00000437966.3",
"protein_id": "ENSP00000399087.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1788,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.964C>T",
"hgvs_p": null,
"transcript": "ENST00000636245.1",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1794,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.*401C>T",
"hgvs_p": null,
"transcript": "ENST00000636271.1",
"protein_id": "ENSP00000490346.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1974,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.1639C>T",
"hgvs_p": null,
"transcript": "ENST00000636292.1",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4843,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.1409C>T",
"hgvs_p": null,
"transcript": "ENST00000637189.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6181,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.*967C>T",
"hgvs_p": null,
"transcript": "ENST00000637350.1",
"protein_id": "ENSP00000489911.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2241,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.*913C>T",
"hgvs_p": null,
"transcript": "ENST00000637519.1",
"protein_id": "ENSP00000490924.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2084,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.1191C>T",
"hgvs_p": null,
"transcript": "NR_046324.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3156,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.*16C>T",
"hgvs_p": null,
"transcript": "ENST00000635884.1",
"protein_id": "ENSP00000489834.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 318,
"cds_start": -4,
"cds_end": null,
"cds_length": 957,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1975,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.*770C>T",
"hgvs_p": null,
"transcript": "ENST00000437966.3",
"protein_id": "ENSP00000399087.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1788,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "n.*401C>T",
"hgvs_p": null,
"transcript": "ENST00000636271.1",
"protein_id": "ENSP00000490346.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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