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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 15-34250934-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=34250934&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "15",
      "pos": 34250934,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "ENST00000354181.8",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1457C>T",
          "hgvs_p": "p.Thr486Met",
          "transcript": "NM_001365088.1",
          "protein_id": "NP_001352017.1",
          "transcript_support_level": null,
          "aa_start": 486,
          "aa_end": null,
          "aa_length": 1150,
          "cds_start": 1457,
          "cds_end": null,
          "cds_length": 3453,
          "cdna_start": 1979,
          "cdna_end": null,
          "cdna_length": 8072,
          "mane_select": "ENST00000354181.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1457C>T",
          "hgvs_p": "p.Thr486Met",
          "transcript": "ENST00000354181.8",
          "protein_id": "ENSP00000346112.3",
          "transcript_support_level": 1,
          "aa_start": 486,
          "aa_end": null,
          "aa_length": 1150,
          "cds_start": 1457,
          "cds_end": null,
          "cds_length": 3453,
          "cdna_start": 1979,
          "cdna_end": null,
          "cdna_length": 8072,
          "mane_select": "NM_001365088.1",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1457C>T",
          "hgvs_p": "p.Thr486Met",
          "transcript": "ENST00000560611.5",
          "protein_id": "ENSP00000454168.1",
          "transcript_support_level": 1,
          "aa_start": 486,
          "aa_end": null,
          "aa_length": 1150,
          "cds_start": 1457,
          "cds_end": null,
          "cds_length": 3453,
          "cdna_start": 1621,
          "cdna_end": null,
          "cdna_length": 4239,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1430C>T",
          "hgvs_p": "p.Thr477Met",
          "transcript": "ENST00000558589.5",
          "protein_id": "ENSP00000452776.1",
          "transcript_support_level": 1,
          "aa_start": 477,
          "aa_end": null,
          "aa_length": 1141,
          "cds_start": 1430,
          "cds_end": null,
          "cds_length": 3426,
          "cdna_start": 1870,
          "cdna_end": null,
          "cdna_length": 3866,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1412C>T",
          "hgvs_p": "p.Thr471Met",
          "transcript": "ENST00000397707.6",
          "protein_id": "ENSP00000380819.2",
          "transcript_support_level": 1,
          "aa_start": 471,
          "aa_end": null,
          "aa_length": 1135,
          "cds_start": 1412,
          "cds_end": null,
          "cds_length": 3408,
          "cdna_start": 1576,
          "cdna_end": null,
          "cdna_length": 4194,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1304C>T",
          "hgvs_p": "p.Thr435Met",
          "transcript": "ENST00000290209.9",
          "protein_id": "ENSP00000290209.5",
          "transcript_support_level": 1,
          "aa_start": 435,
          "aa_end": null,
          "aa_length": 1099,
          "cds_start": 1304,
          "cds_end": null,
          "cds_length": 3300,
          "cdna_start": 1405,
          "cdna_end": null,
          "cdna_length": 7286,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1280C>T",
          "hgvs_p": "p.Thr427Met",
          "transcript": "ENST00000397702.6",
          "protein_id": "ENSP00000380814.2",
          "transcript_support_level": 1,
          "aa_start": 427,
          "aa_end": null,
          "aa_length": 1091,
          "cds_start": 1280,
          "cds_end": null,
          "cds_length": 3276,
          "cdna_start": 1478,
          "cdna_end": null,
          "cdna_length": 4096,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1280C>T",
          "hgvs_p": "p.Thr427Met",
          "transcript": "ENST00000458406.6",
          "protein_id": "ENSP00000387725.2",
          "transcript_support_level": 1,
          "aa_start": 427,
          "aa_end": null,
          "aa_length": 1091,
          "cds_start": 1280,
          "cds_end": null,
          "cds_length": 3276,
          "cdna_start": 1807,
          "cdna_end": null,
          "cdna_length": 4425,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "n.1457C>T",
          "hgvs_p": null,
          "transcript": "ENST00000559664.5",
          "protein_id": "ENSP00000453702.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5111,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "n.1457C>T",
          "hgvs_p": null,
          "transcript": "ENST00000561080.5",
          "protein_id": "ENSP00000454069.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 5407,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
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          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1457C>T",
          "hgvs_p": "p.Thr486Met",
          "transcript": "NM_133647.2",
          "protein_id": "NP_598408.1",
          "transcript_support_level": null,
          "aa_start": 486,
          "aa_end": null,
          "aa_length": 1150,
          "cds_start": 1457,
          "cds_end": null,
          "cds_length": 3453,
          "cdna_start": 1793,
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          "cdna_length": 7886,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1457C>T",
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          "transcript": "ENST00000558667.5",
          "protein_id": "ENSP00000453473.1",
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          "aa_length": 1150,
          "cds_start": 1457,
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          "cdna_start": 1560,
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          "mane_select": null,
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          "biotype": null,
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        },
        {
          "aa_ref": "T",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
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          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1457C>T",
          "hgvs_p": "p.Thr486Met",
          "transcript": "ENST00000676379.1",
          "protein_id": "ENSP00000502539.1",
          "transcript_support_level": null,
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        },
        {
          "aa_ref": "T",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1430C>T",
          "hgvs_p": "p.Thr477Met",
          "transcript": "NM_001042496.2",
          "protein_id": "NP_001035961.1",
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          "feature": null
        },
        {
          "aa_ref": "T",
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          ],
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          "intron_rank": null,
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          "gene_symbol": "SLC12A6",
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          "hgvs_c": "c.1412C>T",
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          "transcript": "NM_001042497.2",
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        },
        {
          "aa_ref": "T",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1304C>T",
          "hgvs_p": "p.Thr435Met",
          "transcript": "NM_005135.2",
          "protein_id": "NP_005126.1",
          "transcript_support_level": null,
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          "feature": null
        },
        {
          "aa_ref": "T",
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          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
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          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1280C>T",
          "hgvs_p": "p.Thr427Met",
          "transcript": "NM_001042494.2",
          "protein_id": "NP_001035959.1",
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        },
        {
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          "intron_rank": null,
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          "gene_symbol": "SLC12A6",
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        },
        {
          "aa_ref": "T",
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          ],
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          "gene_symbol": "SLC12A6",
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          "hgvs_c": "c.893C>T",
          "hgvs_p": "p.Thr298Met",
          "transcript": "ENST00000560164.5",
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          "transcript_support_level": 2,
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          "feature": null
        },
        {
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC12A6",
          "gene_hgnc_id": 10914,
          "hgvs_c": "c.1310C>T",
          "hgvs_p": "p.Thr437Met",
          "transcript": "XM_006720793.5",
          "protein_id": "XP_006720856.1",
          "transcript_support_level": null,
          "aa_start": 437,
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          "aa_length": 1101,
          "cds_start": 1310,
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          "cds_length": 3306,
          "cdna_start": 1646,
          "cdna_end": null,
          "cdna_length": 7739,
          "mane_select": null,
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          "feature": null
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
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          "transcript": "XR_931960.4",
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      ],
      "gene_symbol": "SLC12A6",
      "gene_hgnc_id": 10914,
      "dbsnp": "rs748315324",
      "frequency_reference_population": 0.00001116829,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 18,
      "gnomad_exomes_af": 0.000011647,
      "gnomad_genomes_af": 0.00000657428,
      "gnomad_exomes_ac": 17,
      "gnomad_genomes_ac": 1,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.4327664077281952,
      "computational_prediction_selected": "Uncertain_significance",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.009999999776482582,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.86,
      "revel_prediction": "Pathogenic",
      "alphamissense_score": 0.0845,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": 0.45,
      "bayesdelnoaf_prediction": "Pathogenic",
      "phylop100way_score": 6.816,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0.01,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 0,
          "pathogenic_score": 0,
          "criteria": [],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000354181.8",
          "gene_symbol": "SLC12A6",
          "hgnc_id": 10914,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD,AR",
          "hgvs_c": "c.1457C>T",
          "hgvs_p": "p.Thr486Met"
        }
      ],
      "clinvar_disease": "Agenesis of the corpus callosum with peripheral neuropathy,not provided",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "US:2",
      "phenotype_combined": "not provided|Agenesis of the corpus callosum with peripheral neuropathy",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}