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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-72206852-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=72206852&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 72206852,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001206796.3",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "NM_002654.6",
"protein_id": "NP_002645.3",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000335181.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002654.6"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000335181.10",
"protein_id": "ENSP00000334983.5",
"transcript_support_level": 1,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002654.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000335181.10"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1121G>C",
"hgvs_p": "p.Arg374Pro",
"transcript": "ENST00000565184.6",
"protein_id": "ENSP00000455736.2",
"transcript_support_level": 1,
"aa_start": 374,
"aa_end": null,
"aa_length": 566,
"cds_start": 1121,
"cds_end": null,
"cds_length": 1701,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000565184.6"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000568459.5",
"protein_id": "ENSP00000456970.1",
"transcript_support_level": 1,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000568459.5"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000561609.5",
"protein_id": "ENSP00000457253.1",
"transcript_support_level": 1,
"aa_start": 339,
"aa_end": null,
"aa_length": 484,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000561609.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "n.522G>C",
"hgvs_p": null,
"transcript": "ENST00000563275.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000563275.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1238G>C",
"hgvs_p": "p.Arg413Pro",
"transcript": "NM_001206796.3",
"protein_id": "NP_001193725.1",
"transcript_support_level": null,
"aa_start": 413,
"aa_end": null,
"aa_length": 605,
"cds_start": 1238,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001206796.3"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1238G>C",
"hgvs_p": "p.Arg413Pro",
"transcript": "NM_001411081.1",
"protein_id": "NP_001398010.1",
"transcript_support_level": null,
"aa_start": 413,
"aa_end": null,
"aa_length": 605,
"cds_start": 1238,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001411081.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1238G>C",
"hgvs_p": "p.Arg413Pro",
"transcript": "ENST00000565154.6",
"protein_id": "ENSP00000455901.2",
"transcript_support_level": 2,
"aa_start": 413,
"aa_end": null,
"aa_length": 605,
"cds_start": 1238,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000565154.6"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1238G>C",
"hgvs_p": "p.Arg413Pro",
"transcript": "ENST00000698741.1",
"protein_id": "ENSP00000513903.1",
"transcript_support_level": null,
"aa_start": 413,
"aa_end": null,
"aa_length": 605,
"cds_start": 1238,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698741.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000969850.1",
"protein_id": "ENSP00000639909.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 593,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1782,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969850.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000933441.1",
"protein_id": "ENSP00000603500.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 582,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1749,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933441.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1121G>C",
"hgvs_p": "p.Arg374Pro",
"transcript": "NM_001316318.2",
"protein_id": "NP_001303247.1",
"transcript_support_level": null,
"aa_start": 374,
"aa_end": null,
"aa_length": 566,
"cds_start": 1121,
"cds_end": null,
"cds_length": 1701,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001316318.2"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1031G>C",
"hgvs_p": "p.Arg344Pro",
"transcript": "NM_001206799.2",
"protein_id": "NP_001193728.1",
"transcript_support_level": null,
"aa_start": 344,
"aa_end": null,
"aa_length": 536,
"cds_start": 1031,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001206799.2"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "NM_182470.4",
"protein_id": "NP_872270.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_182470.4"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "NM_182471.4",
"protein_id": "NP_872271.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_182471.4"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000319622.10",
"protein_id": "ENSP00000320171.6",
"transcript_support_level": 2,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000319622.10"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000891959.1",
"protein_id": "ENSP00000562018.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891959.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000891960.1",
"protein_id": "ENSP00000562019.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891960.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000891961.1",
"protein_id": "ENSP00000562020.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891961.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000891962.1",
"protein_id": "ENSP00000562021.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891962.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PKM",
"gene_hgnc_id": 9021,
"hgvs_c": "c.1016G>C",
"hgvs_p": "p.Arg339Pro",
"transcript": "ENST00000891963.1",
"protein_id": "ENSP00000562022.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 531,
"cds_start": 1016,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891963.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
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{
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}
],
"message": null
}