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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-75426328-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=75426328&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 75426328,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000394947.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "NM_001145358.2",
"protein_id": "NP_001138830.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
"cds_end": null,
"cds_length": 3822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6723,
"mane_select": "ENST00000394947.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "ENST00000394947.8",
"protein_id": "ENSP00000378402.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
"cds_end": null,
"cds_length": 3822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6723,
"mane_select": "NM_001145358.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "ENST00000360439.8",
"protein_id": "ENSP00000353622.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
"cds_end": null,
"cds_length": 3822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "ENST00000394949.8",
"protein_id": "ENSP00000378403.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
"cds_end": null,
"cds_length": 3822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4930,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "ENST00000704310.1",
"protein_id": "ENSP00000515832.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1278,
"cds_start": -4,
"cds_end": null,
"cds_length": 3837,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5342,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "NM_001145357.2",
"protein_id": "NP_001138829.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
"cds_end": null,
"cds_length": 3822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6636,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "NM_001437462.1",
"protein_id": "NP_001424391.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
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"cds_length": 3822,
"cdna_start": null,
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"cdna_length": 6821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "NM_001437463.1",
"protein_id": "NP_001424392.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
"cds_end": null,
"cds_length": 3822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6483,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "NM_015477.3",
"protein_id": "NP_056292.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
"cds_end": null,
"cds_length": 3822,
"cdna_start": null,
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"cdna_length": 6786,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 2,
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"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "ENST00000564778.6",
"protein_id": "ENSP00000455204.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 1273,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "ENST00000565264.2",
"protein_id": "ENSP00000454296.2",
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},
{
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"consequences": [
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],
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"gene_symbol": "SIN3A",
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"transcript": "ENST00000704312.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "SIN3A",
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"hgvs_c": "c.190-3505C>A",
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"transcript": "ENST00000567289.5",
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},
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],
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"hgvs_c": "c.190-3505C>A",
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},
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],
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"transcript": "ENST00000568431.5",
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},
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],
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"gene_symbol": "SIN3A",
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},
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],
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"gene_symbol": "SIN3A",
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"transcript": "ENST00000568309.5",
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},
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],
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"gene_symbol": "SIN3A",
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"hgvs_c": "c.190-3505C>A",
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"transcript": "ENST00000568190.1",
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "SIN3A",
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"hgvs_c": "n.190-3054C>A",
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],
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},
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],
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},
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"consequences": [
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "SIN3A",
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"hgvs_c": "c.190-3505C>A",
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"transcript": "XM_047432356.1",
"protein_id": "XP_047288312.1",
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"feature": null
},
{
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"strand": false,
"consequences": [
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],
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"exon_rank_end": null,
"exon_count": 21,
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"gene_symbol": "SIN3A",
"gene_hgnc_id": 19353,
"hgvs_c": "c.190-3505C>A",
"hgvs_p": null,
"transcript": "XM_047432358.1",
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}