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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-81340342-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=81340342&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 81340342,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000359440.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "TMC3",
"gene_hgnc_id": 22995,
"hgvs_c": "c.1845-838C>G",
"hgvs_p": null,
"transcript": "NM_001080532.3",
"protein_id": "NP_001074001.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1100,
"cds_start": -4,
"cds_end": null,
"cds_length": 3303,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4770,
"mane_select": "ENST00000359440.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "TMC3",
"gene_hgnc_id": 22995,
"hgvs_c": "c.1845-838C>G",
"hgvs_p": null,
"transcript": "ENST00000359440.6",
"protein_id": "ENSP00000352413.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1100,
"cds_start": -4,
"cds_end": null,
"cds_length": 3303,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4770,
"mane_select": "NM_001080532.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "TMC3",
"gene_hgnc_id": 22995,
"hgvs_c": "c.1848-838C>G",
"hgvs_p": null,
"transcript": "ENST00000558726.5",
"protein_id": "ENSP00000452681.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1101,
"cds_start": -4,
"cds_end": null,
"cds_length": 3306,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4644,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.392-808G>C",
"hgvs_p": null,
"transcript": "ENST00000559277.2",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1026,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.383-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000559781.6",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2195,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "TMC3",
"gene_hgnc_id": 22995,
"hgvs_c": "n.1927-838C>G",
"hgvs_p": null,
"transcript": "ENST00000559982.1",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2446,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.311-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000560851.2",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1269,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.125-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000560973.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 273,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.316-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000654210.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1386,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.196-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000654536.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1529,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.417+7801G>C",
"hgvs_p": null,
"transcript": "ENST00000662589.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2077,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
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"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.417-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000664001.1",
"protein_id": null,
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"aa_start": null,
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"cds_start": -4,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 2,
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"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.250-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000665273.1",
"protein_id": null,
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"aa_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 2,
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"gene_symbol": "TMC3-AS1",
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"hgvs_c": "n.422-1220G>C",
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"transcript": "ENST00000667509.1",
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},
{
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],
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"gene_symbol": "TMC3-AS1",
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"transcript": "ENST00000667513.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 2,
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"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.379-1220G>C",
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"transcript": "ENST00000667849.2",
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},
{
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],
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},
{
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],
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"exon_count": 4,
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"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.443-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000685783.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.455-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000687585.2",
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},
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],
"exon_rank": null,
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"gene_symbol": "TMC3-AS1",
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},
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],
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"gene_symbol": "TMC3-AS1",
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},
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],
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"intron_rank": 1,
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"gene_symbol": "TMC3-AS1",
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"hgvs_c": "n.258-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000829092.1",
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMC3-AS1",
"gene_hgnc_id": 51424,
"hgvs_c": "n.225-1220G>C",
"hgvs_p": null,
"transcript": "ENST00000829093.1",
"protein_id": null,
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"aa_start": null,
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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