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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-82666761-TC-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=82666761&ref=TC&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 82666761,
"ref": "TC",
"alt": "T",
"effect": "frameshift_variant",
"transcript": "ENST00000535359.6",
"consequences": [
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1837delG",
"hgvs_p": "p.Glu613fs",
"transcript": "NM_001278512.2",
"protein_id": "NP_001265441.1",
"transcript_support_level": null,
"aa_start": 613,
"aa_end": null,
"aa_length": 1101,
"cds_start": 1837,
"cds_end": null,
"cds_length": 3306,
"cdna_start": 2006,
"cdna_end": null,
"cdna_length": 3754,
"mane_select": "ENST00000535359.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1837delG",
"hgvs_p": "p.Glu613fs",
"transcript": "ENST00000535359.6",
"protein_id": "ENSP00000440984.1",
"transcript_support_level": 1,
"aa_start": 613,
"aa_end": null,
"aa_length": 1101,
"cds_start": 1837,
"cds_end": null,
"cds_length": 3306,
"cdna_start": 2006,
"cdna_end": null,
"cdna_length": 3754,
"mane_select": "NM_001278512.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1837delG",
"hgvs_p": "p.Glu613fs",
"transcript": "ENST00000261722.8",
"protein_id": "ENSP00000261722.4",
"transcript_support_level": 1,
"aa_start": 613,
"aa_end": null,
"aa_length": 1088,
"cds_start": 1837,
"cds_end": null,
"cds_length": 3267,
"cdna_start": 2050,
"cdna_end": null,
"cdna_length": 3738,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1741delG",
"hgvs_p": "p.Glu581fs",
"transcript": "ENST00000535348.5",
"protein_id": "ENSP00000438721.1",
"transcript_support_level": 1,
"aa_start": 581,
"aa_end": null,
"aa_length": 1050,
"cds_start": 1741,
"cds_end": null,
"cds_length": 3153,
"cdna_start": 1814,
"cdna_end": null,
"cdna_length": 3254,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.1983delG",
"hgvs_p": null,
"transcript": "ENST00000537735.2",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "CPEB1-AS1",
"gene_hgnc_id": 27523,
"hgvs_c": "n.1328+16617delC",
"hgvs_p": null,
"transcript": "ENST00000560650.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2138,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1837delG",
"hgvs_p": "p.Glu613fs",
"transcript": "ENST00000652847.1",
"protein_id": "ENSP00000499785.1",
"transcript_support_level": null,
"aa_start": 613,
"aa_end": null,
"aa_length": 1130,
"cds_start": 1837,
"cds_end": null,
"cds_length": 3393,
"cdna_start": 2006,
"cdna_end": null,
"cdna_length": 3714,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1966delG",
"hgvs_p": "p.Glu656fs",
"transcript": "ENST00000642989.2",
"protein_id": "ENSP00000493485.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 1125,
"cds_start": 1966,
"cds_end": null,
"cds_length": 3378,
"cdna_start": 1992,
"cdna_end": null,
"cdna_length": 3683,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1837delG",
"hgvs_p": "p.Glu613fs",
"transcript": "NM_004644.5",
"protein_id": "NP_004635.2",
"transcript_support_level": null,
"aa_start": 613,
"aa_end": null,
"aa_length": 1082,
"cds_start": 1837,
"cds_end": null,
"cds_length": 3249,
"cdna_start": 2006,
"cdna_end": null,
"cdna_length": 3697,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1837delG",
"hgvs_p": "p.Glu613fs",
"transcript": "ENST00000668990.2",
"protein_id": "ENSP00000499235.1",
"transcript_support_level": null,
"aa_start": 613,
"aa_end": null,
"aa_length": 1082,
"cds_start": 1837,
"cds_end": null,
"cds_length": 3249,
"cdna_start": 2006,
"cdna_end": null,
"cdna_length": 3697,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1741delG",
"hgvs_p": "p.Glu581fs",
"transcript": "NM_001278511.2",
"protein_id": "NP_001265440.1",
"transcript_support_level": null,
"aa_start": 581,
"aa_end": null,
"aa_length": 1050,
"cds_start": 1741,
"cds_end": null,
"cds_length": 3153,
"cdna_start": 1910,
"cdna_end": null,
"cdna_length": 3601,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1666delG",
"hgvs_p": "p.Glu556fs",
"transcript": "ENST00000669930.1",
"protein_id": "ENSP00000499671.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 1025,
"cds_start": 1666,
"cds_end": null,
"cds_length": 3078,
"cdna_start": 1807,
"cdna_end": null,
"cdna_length": 3461,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.1837delG",
"hgvs_p": "p.Glu613fs",
"transcript": "ENST00000666973.1",
"protein_id": "ENSP00000499288.1",
"transcript_support_level": null,
"aa_start": 613,
"aa_end": null,
"aa_length": 992,
"cds_start": 1837,
"cds_end": null,
"cds_length": 2979,
"cdna_start": 1954,
"cdna_end": null,
"cdna_length": 3420,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.745delG",
"hgvs_p": "p.Glu249fs",
"transcript": "ENST00000660624.1",
"protein_id": "ENSP00000499379.1",
"transcript_support_level": null,
"aa_start": 249,
"aa_end": null,
"aa_length": 718,
"cds_start": 745,
"cds_end": null,
"cds_length": 2157,
"cdna_start": 960,
"cdna_end": null,
"cdna_length": 2650,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.2340delG",
"hgvs_p": null,
"transcript": "ENST00000535385.6",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4201,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.2040delG",
"hgvs_p": null,
"transcript": "ENST00000543938.6",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4168,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.*1461delG",
"hgvs_p": null,
"transcript": "ENST00000657321.1",
"protein_id": "ENSP00000499716.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.1063delG",
"hgvs_p": null,
"transcript": "ENST00000661532.1",
"protein_id": "ENSP00000499583.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2750,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.1979delG",
"hgvs_p": null,
"transcript": "ENST00000663651.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3651,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.*1725delG",
"hgvs_p": null,
"transcript": "ENST00000667758.1",
"protein_id": "ENSP00000499318.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4643,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.*1635delG",
"hgvs_p": null,
"transcript": "ENST00000668385.1",
"protein_id": "ENSP00000499544.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3586,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.1456delG",
"hgvs_p": null,
"transcript": "ENST00000668458.1",
"protein_id": "ENSP00000499573.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2736,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.1776delG",
"hgvs_p": null,
"transcript": "ENST00000679388.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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}