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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-3459056-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=3459056&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 3459056,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000407558.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-7+10516G>T",
"hgvs_p": null,
"transcript": "NM_001083601.3",
"protein_id": "NP_001077070.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 242,
"cds_start": -4,
"cds_end": null,
"cds_length": 729,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2656,
"mane_select": "ENST00000407558.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-7+10516G>T",
"hgvs_p": null,
"transcript": "ENST00000407558.9",
"protein_id": "ENSP00000385903.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 242,
"cds_start": -4,
"cds_end": null,
"cds_length": 729,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2656,
"mane_select": "NM_001083601.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.131+10516G>T",
"hgvs_p": null,
"transcript": "ENST00000424546.6",
"protein_id": "ENSP00000401237.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 249,
"cds_start": -4,
"cds_end": null,
"cds_length": 750,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1149,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-7+875G>T",
"hgvs_p": null,
"transcript": "ENST00000414063.6",
"protein_id": "ENSP00000393224.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 242,
"cds_start": -4,
"cds_end": null,
"cds_length": 729,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2619,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-7+875G>T",
"hgvs_p": null,
"transcript": "ENST00000572584.2",
"protein_id": "ENSP00000459057.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 242,
"cds_start": -4,
"cds_end": null,
"cds_length": 729,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2931,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-7+875G>T",
"hgvs_p": null,
"transcript": "ENST00000575076.5",
"protein_id": "ENSP00000458667.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 242,
"cds_start": -4,
"cds_end": null,
"cds_length": 729,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-86+875G>T",
"hgvs_p": null,
"transcript": "ENST00000360862.9",
"protein_id": "ENSP00000354108.5",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 177,
"cds_start": -4,
"cds_end": null,
"cds_length": 534,
"cdna_start": null,
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"cdna_length": 2522,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-86+15229G>T",
"hgvs_p": null,
"transcript": "ENST00000573580.5",
"protein_id": "ENSP00000459055.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 177,
"cds_start": -4,
"cds_end": null,
"cds_length": 534,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 758,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-86+875G>T",
"hgvs_p": null,
"transcript": "ENST00000577013.6",
"protein_id": "ENSP00000458575.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 177,
"cds_start": -4,
"cds_end": null,
"cds_length": 534,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1124,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "c.-7+875G>T",
"hgvs_p": null,
"transcript": "ENST00000576916.5",
"protein_id": "ENSP00000461703.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 134,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": true,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "NAA60",
"gene_hgnc_id": 25875,
"hgvs_c": "n.-7+875G>T",
"hgvs_p": null,
"transcript": "ENST00000572739.5",
"protein_id": "ENSP00000461438.1",
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},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "NAA60",
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"transcript": "ENST00000573345.5",
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},
{
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"consequences": [
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],
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"gene_symbol": "ENSG00000285329",
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"hgvs_c": "n.281+10516G>T",
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"transcript": "ENST00000575785.2",
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},
{
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],
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"gene_symbol": "NAA60",
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"hgvs_c": "c.131+10516G>T",
"hgvs_p": null,
"transcript": "NM_001317093.1",
"protein_id": "NP_001304022.1",
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},
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],
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"transcript": "NM_001083600.3",
"protein_id": "NP_001077069.1",
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},
{
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],
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"intron_rank": 1,
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"gene_symbol": "NAA60",
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"hgvs_c": "c.-7+875G>T",
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"transcript": "NM_024845.4",
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},
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],
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"gene_symbol": "NAA60",
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"hgvs_c": "c.-7+10516G>T",
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"transcript": "ENST00000572169.6",
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},
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],
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"intron_rank": 3,
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"gene_symbol": "NAA60",
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"hgvs_c": "c.-7+10516G>T",
"hgvs_p": null,
"transcript": "ENST00000649205.1",
"protein_id": "ENSP00000497988.1",
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},
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],
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"intron_rank": 3,
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"gene_symbol": "NAA60",
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"hgvs_c": "c.-7+2140G>T",
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"protein_id": "ENSP00000497411.1",
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},
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],
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},
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],
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},
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],
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"intron_rank": 1,
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"gene_symbol": "NAA60",
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"hgvs_c": "c.-7+875G>T",
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"transcript": "NM_001317097.2",
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"feature": null
},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "NAA60",
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"hgvs_c": "c.-7+875G>T",
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"transcript": "NM_001317098.2",
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},
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