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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-53888926-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=53888926&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 53888926,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000471389.6",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001080432.3",
"protein_id": "NP_001073901.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 505,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1518,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 11573,
"mane_select": "ENST00000471389.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "ENST00000471389.6",
"protein_id": "ENSP00000418823.1",
"transcript_support_level": 1,
"aa_start": 405,
"aa_end": null,
"aa_length": 505,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1518,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 11573,
"mane_select": "NM_001080432.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "ENST00000637969.1",
"protein_id": "ENSP00000490516.1",
"transcript_support_level": 5,
"aa_start": 405,
"aa_end": null,
"aa_length": 559,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1680,
"cdna_start": 1242,
"cdna_end": null,
"cdna_length": 2889,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001363894.2",
"protein_id": "NP_001350823.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 526,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1581,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 4162,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1244C>T",
"hgvs_p": "p.Ala415Val",
"transcript": "NM_001363891.2",
"protein_id": "NP_001350820.1",
"transcript_support_level": null,
"aa_start": 415,
"aa_end": null,
"aa_length": 515,
"cds_start": 1244,
"cds_end": null,
"cds_length": 1548,
"cdna_start": 1273,
"cdna_end": null,
"cdna_length": 4129,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001363896.2",
"protein_id": "NP_001350825.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 499,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1500,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 4081,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001363988.2",
"protein_id": "NP_001350917.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 482,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1449,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 4206,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001438128.1",
"protein_id": "NP_001425057.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 481,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1446,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 2275,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "ENST00000637001.1",
"protein_id": "ENSP00000489936.1",
"transcript_support_level": 5,
"aa_start": 405,
"aa_end": null,
"aa_length": 481,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1446,
"cdna_start": 1330,
"cdna_end": null,
"cdna_length": 1609,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1136C>T",
"hgvs_p": "p.Ala379Val",
"transcript": "NM_001363897.2",
"protein_id": "NP_001350826.1",
"transcript_support_level": null,
"aa_start": 379,
"aa_end": null,
"aa_length": 479,
"cds_start": 1136,
"cds_end": null,
"cds_length": 1440,
"cdna_start": 1165,
"cdna_end": null,
"cdna_length": 4021,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1100C>T",
"hgvs_p": "p.Ala367Val",
"transcript": "NM_001363898.2",
"protein_id": "NP_001350827.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 467,
"cds_start": 1100,
"cds_end": null,
"cds_length": 1404,
"cdna_start": 1129,
"cdna_end": null,
"cdna_length": 3985,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1100C>T",
"hgvs_p": "p.Ala367Val",
"transcript": "NM_001363899.2",
"protein_id": "NP_001350828.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 467,
"cds_start": 1100,
"cds_end": null,
"cds_length": 1404,
"cdna_start": 1129,
"cdna_end": null,
"cdna_length": 3985,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1070C>T",
"hgvs_p": "p.Ala357Val",
"transcript": "NM_001363900.2",
"protein_id": "NP_001350829.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 457,
"cds_start": 1070,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 1099,
"cdna_end": null,
"cdna_length": 3955,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1070C>T",
"hgvs_p": "p.Ala357Val",
"transcript": "NM_001363901.2",
"protein_id": "NP_001350830.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 457,
"cds_start": 1070,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 1099,
"cdna_end": null,
"cdna_length": 3955,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001438129.1",
"protein_id": "NP_001425058.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 457,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 2035,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001438130.1",
"protein_id": "NP_001425059.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 457,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 1621,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "ENST00000636218.1",
"protein_id": "ENSP00000489641.1",
"transcript_support_level": 5,
"aa_start": 405,
"aa_end": null,
"aa_length": 457,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 1436,
"cdna_end": null,
"cdna_length": 2227,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1196C>T",
"hgvs_p": "p.Ala399Val",
"transcript": "ENST00000636491.1",
"protein_id": "ENSP00000490047.1",
"transcript_support_level": 5,
"aa_start": 399,
"aa_end": null,
"aa_length": 450,
"cds_start": 1196,
"cds_end": null,
"cds_length": 1353,
"cdna_start": 1393,
"cdna_end": null,
"cdna_length": 1676,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.1214C>T",
"hgvs_p": "p.Ala405Val",
"transcript": "NM_001363903.2",
"protein_id": "NP_001350832.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 424,
"cds_start": 1214,
"cds_end": null,
"cds_length": 1275,
"cdna_start": 1243,
"cdna_end": null,
"cdna_length": 3974,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.701C>T",
"hgvs_p": "p.Ala234Val",
"transcript": "NM_001363905.2",
"protein_id": "NP_001350834.1",
"transcript_support_level": null,
"aa_start": 234,
"aa_end": null,
"aa_length": 334,
"cds_start": 701,
"cds_end": null,
"cds_length": 1005,
"cdna_start": 1422,
"cdna_end": null,
"cdna_length": 4278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.593C>T",
"hgvs_p": "p.Ala198Val",
"transcript": "ENST00000563011.2",
"protein_id": "ENSP00000489714.1",
"transcript_support_level": 5,
"aa_start": 198,
"aa_end": null,
"aa_length": 274,
"cds_start": 593,
"cds_end": null,
"cds_length": 825,
"cdna_start": 594,
"cdna_end": null,
"cdna_length": 2015,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.239C>T",
"hgvs_p": "p.Ala80Val",
"transcript": "ENST00000612285.2",
"protein_id": "ENSP00000490300.1",
"transcript_support_level": 5,
"aa_start": 80,
"aa_end": null,
"aa_length": 173,
"cds_start": 239,
"cds_end": null,
"cds_length": 522,
"cdna_start": 239,
"cdna_end": null,
"cdna_length": 1852,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FTO",
"gene_hgnc_id": 24678,
"hgvs_c": "c.17C>T",
"hgvs_p": "p.Ala6Val",
"transcript": "ENST00000431610.6",
"protein_id": "ENSP00000415636.2",
"transcript_support_level": 3,
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}
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}