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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-84503104-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=84503104&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 84503104,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_020947.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-26+1497A>G",
"hgvs_p": null,
"transcript": "NM_020947.4",
"protein_id": "NP_065998.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5013,
"mane_select": "ENST00000343629.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_020947.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-26+1497A>G",
"hgvs_p": null,
"transcript": "ENST00000343629.11",
"protein_id": "ENSP00000343635.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5013,
"mane_select": "NM_020947.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000343629.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-167-242A>G",
"hgvs_p": null,
"transcript": "ENST00000899776.1",
"protein_id": "ENSP00000569835.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4330,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899776.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-147-262A>G",
"hgvs_p": null,
"transcript": "ENST00000899777.1",
"protein_id": "ENSP00000569836.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3477,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899777.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-26+1325A>G",
"hgvs_p": null,
"transcript": "ENST00000899778.1",
"protein_id": "ENSP00000569837.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3469,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899778.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-147-262A>G",
"hgvs_p": null,
"transcript": "ENST00000899779.1",
"protein_id": "ENSP00000569838.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3567,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899779.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-147-262A>G",
"hgvs_p": null,
"transcript": "ENST00000899780.1",
"protein_id": "ENSP00000569839.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3516,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899780.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-26+1342A>G",
"hgvs_p": null,
"transcript": "ENST00000899781.1",
"protein_id": "ENSP00000569840.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3002,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899781.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-147-262A>G",
"hgvs_p": null,
"transcript": "ENST00000899782.1",
"protein_id": "ENSP00000569841.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1880,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899782.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-25-4993A>G",
"hgvs_p": null,
"transcript": "ENST00000926571.1",
"protein_id": "ENSP00000596630.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
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"cds_length": 1371,
"cdna_start": null,
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"cdna_length": 3534,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926571.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 1,
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"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-267-262A>G",
"hgvs_p": null,
"transcript": "ENST00000926572.1",
"protein_id": "ENSP00000596631.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "MEAK7",
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"hgvs_c": "c.-24+1497A>G",
"hgvs_p": null,
"transcript": "ENST00000926574.1",
"protein_id": "ENSP00000596633.1",
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"cds_start": null,
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"feature": "ENST00000926574.1"
},
{
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"canonical": false,
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
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"gene_symbol": "MEAK7",
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"hgvs_c": "c.-26+1493A>G",
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"cds_start": null,
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},
{
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],
"exon_rank": null,
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"gene_symbol": "MEAK7",
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},
{
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"strand": false,
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],
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"exon_count": 9,
"intron_rank": 1,
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"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-147-262A>G",
"hgvs_p": null,
"transcript": "ENST00000926575.1",
"protein_id": "ENSP00000596634.1",
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"aa_start": null,
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"mane_select": null,
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},
{
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"strand": false,
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],
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"gene_symbol": "MEAK7",
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"hgvs_c": "c.-167-242A>G",
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"transcript": "ENST00000926573.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-26+1497A>G",
"hgvs_p": null,
"transcript": "ENST00000926576.1",
"protein_id": "ENSP00000596635.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000926576.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-25-4993A>G",
"hgvs_p": null,
"transcript": "ENST00000565079.5",
"protein_id": "ENSP00000457557.1",
"transcript_support_level": 4,
"aa_start": null,
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"mane_select": null,
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},
{
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"consequences": [
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],
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"gene_symbol": "MEAK7",
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"hgvs_p": null,
"transcript": "ENST00000562447.5",
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},
{
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"strand": false,
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],
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"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
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"hgvs_c": "c.-167-242A>G",
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"transcript": "ENST00000565765.1",
"protein_id": "ENSP00000455557.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
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"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-26+854A>G",
"hgvs_p": null,
"transcript": "XM_005256075.3",
"protein_id": "XP_005256132.1",
"transcript_support_level": null,
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"aa_end": null,
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"cds_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005256075.3"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MEAK7",
"gene_hgnc_id": 29325,
"hgvs_c": "c.-26+1325A>G",
"hgvs_p": null,
"transcript": "XM_017023511.2",
"protein_id": "XP_016879000.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": 5185,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017023511.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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{
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"verdict": "Benign",
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"clinvar_disease": "",
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}
],
"message": null
}